Academic Journal
Mortality Trends of Biliary Tract Cancers in the United States, 1999-2023: a CDC-WONDER Analysis.
| Τίτλος: | Mortality Trends of Biliary Tract Cancers in the United States, 1999-2023: a CDC-WONDER Analysis. |
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| Συγγραφείς: | Chen J; Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China., Yang G; Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China., Sun X; Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China. sxd@jlu.edu.cn. |
| Πηγή: | Journal of gastrointestinal cancer [J Gastrointest Cancer] 2026 Jul 24; Vol. 57 (1). Date of Electronic Publication: 2026 Jul 24. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: United States NLM ID: 101479627 Publication Model: Electronic Cited Medium: Internet ISSN: 1941-6636 (Electronic) NLM ISO Abbreviation: J Gastrointest Cancer Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2010- : New York : Springer Original Publication: New York, NY : Humana Press |
| Ιατρικοί όροι (MeSH): | Biliary Tract Neoplasms*/mortality , Mortality*/trends, United States/epidemiology ; Cholangiocarcinoma/mortality ; Humans ; Female ; Male ; Aged ; Middle Aged ; Adult ; Aged, 80 and over |
| Περίληψη: | Background: Biliary tract cancers (BTCs) comprise a heterogeneous group of malignancies, including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, gallbladder cancer, ampulla of Vater tumors, and other or unspecified BTCs. We examined population-level BTC mortality trends and disparities in the US from 1999 to 2023. Methods: Deaths among adults aged ≥ 35 years were obtained from CDC WONDER using ICD-10 codes C22.1, C23, C24.0, C24.1, C24.8, and C24.9. AAMRs per 100,000 were calculated and assessed using Joinpoint regression, with stratification by sex, race/ethnicity, age, census region, and urbanization level. Urbanization analyses used standardized data through 2020. Results: From 1999 to 2023, 226,056 BTC deaths were recorded. Annual deaths increased from 6,121 to 13,637, and the AAMR increased from 4.37 to 6.10 per 100,000 (AAPC, 2.22%; 95% CI, 1.95%-2.50%; P < 0.001), with acceleration after 2007. The Non-Hispanic Black population exhibited the fastest increase in mortality among racial/ethnic groups, with an AAPC of 3.20%, whereas Hispanics had the highest AAMR in 2023. The 35-44-year age group showed the fastest increase despite low mortality (AAPC, 3.77%). In 2023, the Midwest had the highest AAMR, at 5.50 per 100,000, followed by the West at 5.32 per 100,000. In standardized urbanization-stratified data through 2020, metropolitan areas had a higher AAMR than nonmetropolitan areas (4.65 vs. 4.30 per 100,000). Subtype-specific analyses showed that intrahepatic cholangiocarcinoma accounted for the largest proportion of deaths (132,830; 58.76%) and had an increasing AAMR from 1.82 to 4.17 per 100,000, whereas gallbladder cancer accounted for 51,720 deaths (22.88%) and had a declining AAMR from 1.46 to 0.98 per 100,000. Extrahepatic bile duct cancer, ampulla of Vater cancer, and other/unspecified BTCs contributed 18,669, 5,135, and 17,702 deaths, respectively, highlighting that pooled BTC estimates may mask divergent subtype patterns. These opposite iCCA and GBC patterns supported separate subtype reporting rather than interpretation of the pooled BTC estimate alone in this study. Conclusions: BTC mortality among US adults aged ≥ 35 years increased from 1999 to 2023, with demographic, geographic, urbanization-related, and subtype-specific heterogeneity. These findings support subtype-aware surveillance, early detection, and equitable resource allocation. (© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Competing Interests: | Declarations. Conflict of Interest: The authors declare no competing interests. |
| References: | Zhang X, Gui X, Zhang Y, et al. A panel of bile volatile organic compounds servers as a potential diagnostic biomarker for gallbladder cancer. Front Oncol. 2022;12:858639. (PMID: 10.3389/fonc.2022.858639354334209006947) Feng H, Tong H, Yan J, et al. Genomic features and clinical characteristics of adolescents and young adults with cholangiocarcinoma. Front Oncol. 2019;9:1439. (PMID: 10.3389/fonc.2019.0143932010606) Banales JM, Rodrigues PM, Affò S, et al. Cholangiocarcinoma 2026: status quo, unmet needs and priorities. Nat Rev Gastroenterol Hepatol. 2026;23(1):65–96. (PMID: 10.1038/s41575-025-01153-w41372578) Rehman OU, Hayat MS, Shoaib MM, et al. Trends and disparities in intrahepatic cholangiocarcinoma-related mortality in the United States from 1999 to 2020. J Gastrointest Cancer. 2025;56(1):53. (PMID: 10.1007/s12029-024-01132-539869219) Minhas AMK, Al-Kindi S, Van Spall HGC, et al. Comparing cardiovascular mortality estimates from Global Burden of Disease and from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research. Circ Cardiovasc Qual Outcomes. 2025;18(5):e011459. (PMID: 10.1161/CIRCOUTCOMES.124.01145940184153) Hughes DJ, Duarte-Salles T, Hybsier S, et al. Prediagnostic selenium status and hepatobiliary cancer risk in the European prospective investigation into cancer and nutrition cohort. Am J Clin Nutr. 2016;104(2):406–14. (PMID: 10.3945/ajcn.116.131672273570896284791) Alyahya A, Albegamy Y, Albalawi MA, et al. Trends in mortality from high-risk surgical procedures: national burden of Transplants, Implants, and Organ removal from 1999 to 2024 in United States. Am J Surg. 2026;254:116825. (PMID: 10.1016/j.amjsurg.2026.11682541548319) Haseeb A, Muhammad Umer Nasrullah R, Siddiq MA, et al. Trends in malignant neoplasm of bone and articular cartilage related mortality among older adults in United States (1999–2020). Ann Med Surg. 1999;86(11):6645–52. (PMID: 10.1097/MS9.0000000000002629) Ahmed M, Hasan M, Kumar S, et al. Trends and forecast of heart failure-related deaths in US chronic obstructive pulmonary disease patients (1999-2030): insights from advanced time-series modeling. Cardiol Rev. 1999. https://doi.org/10.1097/crd.0000000000001083 . (PMID: 10.1097/crd.0000000000001083) Kumar L, Ali T, Iqbal F, et al. Unveiling trends in urinary tract cancer mortality among older adults in the United States (1999–2022): a CDC WONDER perspective. Int Urol Nephrol. 2025;57(10):3151–61. (PMID: 10.1007/s11255-025-04490-640186733) Van Dyke AL, Shiels MS, Jones GS, et al. Biliary tract cancer incidence and trends in the United States by demographic group, 1999–2013. Cancer. 1999;125(9):1489–98. (PMID: 10.1002/cncr.31942) Petrick JL, Yang B, Altekruse SF, et al. Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based study in SEER-Medicare. PLoS ONE. 2017;12(10):e0186643. (PMID: 10.1371/journal.pone.0186643290494015648218) Hemminki K, Sundquist K, Sundquist J, et al. Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers. Int J Cancer. 2023;152(6):1107–14. (PMID: 10.1002/ijc.3430836196489) Wu G, Xu X, Zhang H, et al. Liquid biopsy in biliary tract cancers: early diagnosis, precision therapy, and prognostic evaluation. Front Oncol. 2025;15:1705162. (PMID: 10.3389/fonc.2025.17051624148757412757225) Kumar L, Mustafa I, Kumar N, et al. Temporal trends in mortality attributable to atrial fibrillation among adults with acute renal failure in the United States, 1999-2024. Int Urol Nephrol. 1999. https://doi.org/10.1007/s11255-025-04924-1 . (PMID: 10.1007/s11255-025-04924-1) Rani S, Kumar L, Ali SME, et al. Trends in United States mortality among patients with atrial fibrillation/flutter related heart failure (1999-2024): disparities by gender, race/ethnicity and region. BMC Cardiovasc Disord. 1999;25(1):558. (PMID: 10.1186/s12872-025-05036-5) Mahmood A, Latif F, Latif S, et al. Heart failure and tobacco use disorder: mortality trends and disparities in the United States. Ann Med Surg (Lond). 2026;88(2):1639–47. (PMID: 10.1097/MS9.00000000000047294167581512889312) Ellington TD, Momin B, Wilson RJ, et al. Incidence and mortality of cancers of the biliary tract, gallbladder, and liver by sex, age, race/ethnicity, and stage at diagnosis: United States, 2013 to 2017. Cancer Epidemiol Biomarkers Prev. 2013;30(9):1607–14. (PMID: 10.1158/1055-9965.EPI-21-0265) Raja A, Raja S, Amin SB, et al. Temporal trends in hypertension related end stage renal disease mortality rates: an analysis of gender, race/ethnicity, and geographic disparities in the United States. Front Nephrol. 2023;3:1339312. (PMID: 10.3389/fneph.2023.133931238288382) Kim HJ, Fay MP, Feuer EJ, et al. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med. 2000;19(3):335–51. (PMID: 10.1002/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z10649300) Martin AN, Chan NW, Cheung DC, et al. A guide to large data sets for population-based cancer research: strengths, limitations, and pitfalls. Cancer. 2024;130(22):3802–14. (PMID: 10.1002/cncr.3553539158578) |
| Contributed Indexing: | Keywords: Age-adjusted mortality rate; Biliary tract cancers; CDC WONDER; Cholangiocarcinoma; Gallbladder cancer; Joinpoint regression; Mortality |
| Entry Date(s): | Date Created: 20260724 Date Completed: 20260724 Latest Revision: 20260724 |
| Update Code: | 20260725 |
| DOI: | 10.1007/s12029-026-01537-4 |
| PMID: | 42498813 |
| Βάση Δεδομένων: | MEDLINE |
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