Academic Journal
Προβολή σε EDS
Συνδεδεμένο Πλήρες Κείμενο

Mortality Trends of Biliary Tract Cancers in the United States, 1999-2023: a CDC-WONDER Analysis.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Mortality Trends of Biliary Tract Cancers in the United States, 1999-2023: a CDC-WONDER Analysis.
Συγγραφείς: Chen J; Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China., Yang G; Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China., Sun X; Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China. sxd@jlu.edu.cn.
Πηγή: Journal of gastrointestinal cancer [J Gastrointest Cancer] 2026 Jul 24; Vol. 57 (1). Date of Electronic Publication: 2026 Jul 24.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: United States NLM ID: 101479627 Publication Model: Electronic Cited Medium: Internet ISSN: 1941-6636 (Electronic) NLM ISO Abbreviation: J Gastrointest Cancer Subsets: MEDLINE
Imprint Name(s): Publication: 2010- : New York : Springer
Original Publication: New York, NY : Humana Press
Ιατρικοί όροι (MeSH): Biliary Tract Neoplasms*/mortality , Mortality*/trends, United States/epidemiology ; Cholangiocarcinoma/mortality ; Humans ; Female ; Male ; Aged ; Middle Aged ; Adult ; Aged, 80 and over
Περίληψη: Background: Biliary tract cancers (BTCs) comprise a heterogeneous group of malignancies, including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, gallbladder cancer, ampulla of Vater tumors, and other or unspecified BTCs. We examined population-level BTC mortality trends and disparities in the US from 1999 to 2023.
Methods: Deaths among adults aged ≥ 35 years were obtained from CDC WONDER using ICD-10 codes C22.1, C23, C24.0, C24.1, C24.8, and C24.9. AAMRs per 100,000 were calculated and assessed using Joinpoint regression, with stratification by sex, race/ethnicity, age, census region, and urbanization level. Urbanization analyses used standardized data through 2020.
Results: From 1999 to 2023, 226,056 BTC deaths were recorded. Annual deaths increased from 6,121 to 13,637, and the AAMR increased from 4.37 to 6.10 per 100,000 (AAPC, 2.22%; 95% CI, 1.95%-2.50%; P < 0.001), with acceleration after 2007. The Non-Hispanic Black population exhibited the fastest increase in mortality among racial/ethnic groups, with an AAPC of 3.20%, whereas Hispanics had the highest AAMR in 2023. The 35-44-year age group showed the fastest increase despite low mortality (AAPC, 3.77%). In 2023, the Midwest had the highest AAMR, at 5.50 per 100,000, followed by the West at 5.32 per 100,000. In standardized urbanization-stratified data through 2020, metropolitan areas had a higher AAMR than nonmetropolitan areas (4.65 vs. 4.30 per 100,000). Subtype-specific analyses showed that intrahepatic cholangiocarcinoma accounted for the largest proportion of deaths (132,830; 58.76%) and had an increasing AAMR from 1.82 to 4.17 per 100,000, whereas gallbladder cancer accounted for 51,720 deaths (22.88%) and had a declining AAMR from 1.46 to 0.98 per 100,000. Extrahepatic bile duct cancer, ampulla of Vater cancer, and other/unspecified BTCs contributed 18,669, 5,135, and 17,702 deaths, respectively, highlighting that pooled BTC estimates may mask divergent subtype patterns. These opposite iCCA and GBC patterns supported separate subtype reporting rather than interpretation of the pooled BTC estimate alone in this study.
Conclusions: BTC mortality among US adults aged ≥ 35 years increased from 1999 to 2023, with demographic, geographic, urbanization-related, and subtype-specific heterogeneity. These findings support subtype-aware surveillance, early detection, and equitable resource allocation.
(© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests: Declarations. Conflict of Interest: The authors declare no competing interests.
References: Zhang X, Gui X, Zhang Y, et al. A panel of bile volatile organic compounds servers as a potential diagnostic biomarker for gallbladder cancer. Front Oncol. 2022;12:858639. (PMID: 10.3389/fonc.2022.858639354334209006947)
Feng H, Tong H, Yan J, et al. Genomic features and clinical characteristics of adolescents and young adults with cholangiocarcinoma. Front Oncol. 2019;9:1439. (PMID: 10.3389/fonc.2019.0143932010606)
Banales JM, Rodrigues PM, Affò S, et al. Cholangiocarcinoma 2026: status quo, unmet needs and priorities. Nat Rev Gastroenterol Hepatol. 2026;23(1):65–96. (PMID: 10.1038/s41575-025-01153-w41372578)
Rehman OU, Hayat MS, Shoaib MM, et al. Trends and disparities in intrahepatic cholangiocarcinoma-related mortality in the United States from 1999 to 2020. J Gastrointest Cancer. 2025;56(1):53. (PMID: 10.1007/s12029-024-01132-539869219)
Minhas AMK, Al-Kindi S, Van Spall HGC, et al. Comparing cardiovascular mortality estimates from Global Burden of Disease and from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research. Circ Cardiovasc Qual Outcomes. 2025;18(5):e011459. (PMID: 10.1161/CIRCOUTCOMES.124.01145940184153)
Hughes DJ, Duarte-Salles T, Hybsier S, et al. Prediagnostic selenium status and hepatobiliary cancer risk in the European prospective investigation into cancer and nutrition cohort. Am J Clin Nutr. 2016;104(2):406–14. (PMID: 10.3945/ajcn.116.131672273570896284791)
Alyahya A, Albegamy Y, Albalawi MA, et al. Trends in mortality from high-risk surgical procedures: national burden of Transplants, Implants, and Organ removal from 1999 to 2024 in United States. Am J Surg. 2026;254:116825. (PMID: 10.1016/j.amjsurg.2026.11682541548319)
Haseeb A, Muhammad Umer Nasrullah R, Siddiq MA, et al. Trends in malignant neoplasm of bone and articular cartilage related mortality among older adults in United States (1999–2020). Ann Med Surg. 1999;86(11):6645–52. (PMID: 10.1097/MS9.0000000000002629)
Ahmed M, Hasan M, Kumar S, et al. Trends and forecast of heart failure-related deaths in US chronic obstructive pulmonary disease patients (1999-2030): insights from advanced time-series modeling. Cardiol Rev. 1999. https://doi.org/10.1097/crd.0000000000001083 . (PMID: 10.1097/crd.0000000000001083)
Kumar L, Ali T, Iqbal F, et al. Unveiling trends in urinary tract cancer mortality among older adults in the United States (1999–2022): a CDC WONDER perspective. Int Urol Nephrol. 2025;57(10):3151–61. (PMID: 10.1007/s11255-025-04490-640186733)
Van Dyke AL, Shiels MS, Jones GS, et al. Biliary tract cancer incidence and trends in the United States by demographic group, 1999–2013. Cancer. 1999;125(9):1489–98. (PMID: 10.1002/cncr.31942)
Petrick JL, Yang B, Altekruse SF, et al. Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based study in SEER-Medicare. PLoS ONE. 2017;12(10):e0186643. (PMID: 10.1371/journal.pone.0186643290494015648218)
Hemminki K, Sundquist K, Sundquist J, et al. Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers. Int J Cancer. 2023;152(6):1107–14. (PMID: 10.1002/ijc.3430836196489)
Wu G, Xu X, Zhang H, et al. Liquid biopsy in biliary tract cancers: early diagnosis, precision therapy, and prognostic evaluation. Front Oncol. 2025;15:1705162. (PMID: 10.3389/fonc.2025.17051624148757412757225)
Kumar L, Mustafa I, Kumar N, et al. Temporal trends in mortality attributable to atrial fibrillation among adults with acute renal failure in the United States, 1999-2024. Int Urol Nephrol. 1999. https://doi.org/10.1007/s11255-025-04924-1 . (PMID: 10.1007/s11255-025-04924-1)
Rani S, Kumar L, Ali SME, et al. Trends in United States mortality among patients with atrial fibrillation/flutter related heart failure (1999-2024): disparities by gender, race/ethnicity and region. BMC Cardiovasc Disord. 1999;25(1):558. (PMID: 10.1186/s12872-025-05036-5)
Mahmood A, Latif F, Latif S, et al. Heart failure and tobacco use disorder: mortality trends and disparities in the United States. Ann Med Surg (Lond). 2026;88(2):1639–47. (PMID: 10.1097/MS9.00000000000047294167581512889312)
Ellington TD, Momin B, Wilson RJ, et al. Incidence and mortality of cancers of the biliary tract, gallbladder, and liver by sex, age, race/ethnicity, and stage at diagnosis: United States, 2013 to 2017. Cancer Epidemiol Biomarkers Prev. 2013;30(9):1607–14. (PMID: 10.1158/1055-9965.EPI-21-0265)
Raja A, Raja S, Amin SB, et al. Temporal trends in hypertension related end stage renal disease mortality rates: an analysis of gender, race/ethnicity, and geographic disparities in the United States. Front Nephrol. 2023;3:1339312. (PMID: 10.3389/fneph.2023.133931238288382)
Kim HJ, Fay MP, Feuer EJ, et al. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med. 2000;19(3):335–51. (PMID: 10.1002/(SICI)1097-0258(20000215)19:3<335::AID-SIM336>3.0.CO;2-Z10649300)
Martin AN, Chan NW, Cheung DC, et al. A guide to large data sets for population-based cancer research: strengths, limitations, and pitfalls. Cancer. 2024;130(22):3802–14. (PMID: 10.1002/cncr.3553539158578)
Contributed Indexing: Keywords: Age-adjusted mortality rate; Biliary tract cancers; CDC WONDER; Cholangiocarcinoma; Gallbladder cancer; Joinpoint regression; Mortality
Entry Date(s): Date Created: 20260724 Date Completed: 20260724 Latest Revision: 20260724
Update Code: 20260725
DOI: 10.1007/s12029-026-01537-4
PMID: 42498813
Βάση Δεδομένων: MEDLINE
FullText Links:
  – Type: other
    Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=4C3B905C82176771E823&Show=Object
Text:
  Availability: 0
CustomLinks:
  – Url: https://dx.doi.org/doi:10.1007/s12029-026-01537-4
    Name: EDS - Springer Nature Journals (s7799221)
    Category: fullText
    Text: View record at Springer
Header DbId: cmedm
DbLabel: MEDLINE
An: 42498813
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mortality Trends of Biliary Tract Cancers in the United States, 1999-2023: a CDC-WONDER Analysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Chen+J%22&quot;&gt;Chen J&lt;/searchLink&gt;; Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Yang+G%22&quot;&gt;Yang G&lt;/searchLink&gt;; Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Sun+X%22&quot;&gt;Sun X&lt;/searchLink&gt;; Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China. sxd@jlu.edu.cn.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22101479627%22&quot;&gt;Journal of gastrointestinal cancer&lt;/searchLink&gt; [J Gastrointest Cancer] 2026 Jul 24; Vol. 57 (1). &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2026 Jul 24.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: &lt;i&gt;Publisher: &lt;/i&gt;&lt;searchLink fieldCode=&quot;PB&quot; term=&quot;%22Springer%22&quot;&gt;Springer &lt;/searchLink&gt;&lt;i&gt;Country of Publication: &lt;/i&gt;United States &lt;i&gt;NLM ID: &lt;/i&gt;101479627 &lt;i&gt;Publication Model: &lt;/i&gt;Electronic &lt;i&gt;Cited Medium: &lt;/i&gt;Internet &lt;i&gt;ISSN: &lt;/i&gt;1941-6636 (Electronic) &lt;i&gt;NLM ISO Abbreviation: &lt;/i&gt;J Gastrointest Cancer &lt;i&gt;Subsets: &lt;/i&gt;MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: &lt;i&gt;Publication&lt;/i&gt;: 2010- : New York : Springer&lt;br /&gt;&lt;i&gt;Original Publication&lt;/i&gt;: New York, NY : Humana Press
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Biliary+Tract+Neoplasms%22&quot;&gt;Biliary Tract Neoplasms*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Biliary+Tract+Neoplasms+mortality%22&quot;&gt;mortality&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Mortality%22&quot;&gt;Mortality*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Mortality+trends%22&quot;&gt;trends&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22United+States%22&quot;&gt;United States&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22United+States+epidemiology%22&quot;&gt;epidemiology&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Cholangiocarcinoma%22&quot;&gt;Cholangiocarcinoma&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Cholangiocarcinoma+mortality%22&quot;&gt;mortality&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Female%22&quot;&gt;Female&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Male%22&quot;&gt;Male&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Aged%22&quot;&gt;Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Middle+Aged%22&quot;&gt;Middle Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Adult%22&quot;&gt;Adult&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Aged%2C+80+and+over%22&quot;&gt;Aged, 80 and over&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Biliary tract cancers (BTCs) comprise a heterogeneous group of malignancies, including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, gallbladder cancer, ampulla of Vater tumors, and other or unspecified BTCs. We examined population-level BTC mortality trends and disparities in the US from 1999 to 2023.&lt;br /&gt;Methods: Deaths among adults aged ≥ 35&#160;years were obtained from CDC WONDER using ICD-10 codes C22.1, C23, C24.0, C24.1, C24.8, and C24.9. AAMRs per 100,000 were calculated and assessed using Joinpoint regression, with stratification by sex, race/ethnicity, age, census region, and urbanization level. Urbanization analyses used standardized data through 2020.&lt;br /&gt;Results: From 1999 to 2023, 226,056 BTC deaths were recorded. Annual deaths increased from 6,121 to 13,637, and the AAMR increased from 4.37 to 6.10 per 100,000 (AAPC, 2.22%; 95% CI, 1.95%-2.50%; P &amp;lt; 0.001), with acceleration after 2007. The Non-Hispanic Black population exhibited the fastest increase in mortality among racial/ethnic groups, with an AAPC of 3.20%, whereas Hispanics had the highest AAMR in 2023. The 35-44-year age group showed the fastest increase despite low mortality (AAPC, 3.77%). In 2023, the Midwest had the highest AAMR, at 5.50 per 100,000, followed by the West at 5.32 per 100,000. In standardized urbanization-stratified data through 2020, metropolitan areas had a higher AAMR than nonmetropolitan areas (4.65 vs. 4.30 per 100,000). Subtype-specific analyses showed that intrahepatic cholangiocarcinoma accounted for the largest proportion of deaths (132,830; 58.76%) and had an increasing AAMR from 1.82 to 4.17 per 100,000, whereas gallbladder cancer accounted for 51,720 deaths (22.88%) and had a declining AAMR from 1.46 to 0.98 per 100,000. Extrahepatic bile duct cancer, ampulla of Vater cancer, and other/unspecified BTCs contributed 18,669, 5,135, and 17,702 deaths, respectively, highlighting that pooled BTC estimates may mask divergent subtype patterns. These opposite iCCA and GBC patterns supported separate subtype reporting rather than interpretation of the pooled BTC estimate alone in this study.&lt;br /&gt;Conclusions: BTC mortality among US adults aged ≥ 35&#160;years increased from 1999 to 2023, with demographic, geographic, urbanization-related, and subtype-specific heterogeneity. These findings support subtype-aware surveillance, early detection, and equitable resource allocation.&lt;br /&gt; (&#169; 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Conflict of Interest: The authors declare no competing interests.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Zhang X, Gui X, Zhang Y, et al. A panel of bile volatile organic compounds servers as a potential diagnostic biomarker for gallbladder cancer. Front Oncol. 2022;12:858639. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E3389%2Ffonc%2E2022%2E858639354334209006947%22&quot;&gt;10.3389/fonc.2022.858639354334209006947)&lt;/searchLink&gt;&lt;br /&gt;Feng H, Tong H, Yan J, et al. Genomic features and clinical characteristics of adolescents and young adults with cholangiocarcinoma. Front Oncol. 2019;9:1439. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E3389%2Ffonc%2E2019%2E0143932010606%22&quot;&gt;10.3389/fonc.2019.0143932010606)&lt;/searchLink&gt;&lt;br /&gt;Banales JM, Rodrigues PM, Aff&#242; S, et al. Cholangiocarcinoma 2026: status quo, unmet needs and priorities. Nat Rev Gastroenterol Hepatol. 2026;23(1):65–96. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1038%2Fs41575-025-01153-w41372578%22&quot;&gt;10.1038/s41575-025-01153-w41372578)&lt;/searchLink&gt;&lt;br /&gt;Rehman OU, Hayat MS, Shoaib MM, et al. Trends and disparities in intrahepatic cholangiocarcinoma-related mortality in the United States from 1999 to 2020. J Gastrointest Cancer. 2025;56(1):53. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1007%2Fs12029-024-01132-539869219%22&quot;&gt;10.1007/s12029-024-01132-539869219)&lt;/searchLink&gt;&lt;br /&gt;Minhas AMK, Al-Kindi S, Van Spall HGC, et al. Comparing cardiovascular mortality estimates from Global Burden of Disease and from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiological Research. Circ Cardiovasc Qual Outcomes. 2025;18(5):e011459. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1161%2FCIRCOUTCOMES%2E124%2E01145940184153%22&quot;&gt;10.1161/CIRCOUTCOMES.124.01145940184153)&lt;/searchLink&gt;&lt;br /&gt;Hughes DJ, Duarte-Salles T, Hybsier S, et al. Prediagnostic selenium status and hepatobiliary cancer risk in the European prospective investigation into cancer and nutrition cohort. Am J Clin Nutr. 2016;104(2):406–14. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E3945%2Fajcn%2E116%2E131672273570896284791%22&quot;&gt;10.3945/ajcn.116.131672273570896284791)&lt;/searchLink&gt;&lt;br /&gt;Alyahya A, Albegamy Y, Albalawi MA, et al. Trends in mortality from high-risk surgical procedures: national burden of Transplants, Implants, and Organ removal from 1999 to 2024 in United States. Am J Surg. 2026;254:116825. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1016%2Fj%2Eamjsurg%2E2026%2E11682541548319%22&quot;&gt;10.1016/j.amjsurg.2026.11682541548319)&lt;/searchLink&gt;&lt;br /&gt;Haseeb A, Muhammad Umer Nasrullah R, Siddiq MA, et al. Trends in malignant neoplasm of bone and articular cartilage related mortality among older adults in United States (1999–2020). Ann Med Surg. 1999;86(11):6645–52. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1097%2FMS9%2E0000000000002629%22&quot;&gt;10.1097/MS9.0000000000002629)&lt;/searchLink&gt;&lt;br /&gt;Ahmed M, Hasan M, Kumar S, et al. Trends and forecast of heart failure-related deaths in US chronic obstructive pulmonary disease patients (1999-2030): insights from advanced time-series modeling. Cardiol Rev. 1999. https://doi.org/10.1097/crd.0000000000001083 . (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1097%2Fcrd%2E0000000000001083%22&quot;&gt;10.1097/crd.0000000000001083)&lt;/searchLink&gt;&lt;br /&gt;Kumar L, Ali T, Iqbal F, et al. Unveiling trends in urinary tract cancer mortality among older adults in the United States (1999–2022): a CDC WONDER perspective. Int Urol Nephrol. 2025;57(10):3151–61. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1007%2Fs11255-025-04490-640186733%22&quot;&gt;10.1007/s11255-025-04490-640186733)&lt;/searchLink&gt;&lt;br /&gt;Van Dyke AL, Shiels MS, Jones GS, et al. Biliary tract cancer incidence and trends in the United States by demographic group, 1999–2013. Cancer. 1999;125(9):1489–98. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1002%2Fcncr%2E31942%22&quot;&gt;10.1002/cncr.31942)&lt;/searchLink&gt;&lt;br /&gt;Petrick JL, Yang B, Altekruse SF, et al. Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based study in SEER-Medicare. PLoS ONE. 2017;12(10):e0186643. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1371%2Fjournal%2Epone%2E0186643290494015648218%22&quot;&gt;10.1371/journal.pone.0186643290494015648218)&lt;/searchLink&gt;&lt;br /&gt;Hemminki K, Sundquist K, Sundquist J, et al. Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers. Int J Cancer. 2023;152(6):1107–14. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1002%2Fijc%2E3430836196489%22&quot;&gt;10.1002/ijc.3430836196489)&lt;/searchLink&gt;&lt;br /&gt;Wu G, Xu X, Zhang H, et al. Liquid biopsy in biliary tract cancers: early diagnosis, precision therapy, and prognostic evaluation. Front Oncol. 2025;15:1705162. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E3389%2Ffonc%2E2025%2E17051624148757412757225%22&quot;&gt;10.3389/fonc.2025.17051624148757412757225)&lt;/searchLink&gt;&lt;br /&gt;Kumar L, Mustafa I, Kumar N, et al. Temporal trends in mortality attributable to atrial fibrillation among adults with acute renal failure in the United States, 1999-2024. Int Urol Nephrol. 1999. https://doi.org/10.1007/s11255-025-04924-1 . (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1007%2Fs11255-025-04924-1%22&quot;&gt;10.1007/s11255-025-04924-1)&lt;/searchLink&gt;&lt;br /&gt;Rani S, Kumar L, Ali SME, et al. Trends in United States mortality among patients with atrial fibrillation/flutter related heart failure (1999-2024): disparities by gender, race/ethnicity and region. BMC Cardiovasc Disord. 1999;25(1):558. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1186%2Fs12872-025-05036-5%22&quot;&gt;10.1186/s12872-025-05036-5)&lt;/searchLink&gt;&lt;br /&gt;Mahmood A, Latif F, Latif S, et al. Heart failure and tobacco use disorder: mortality trends and disparities in the United States. Ann Med Surg (Lond). 2026;88(2):1639–47. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1097%2FMS9%2E00000000000047294167581512889312%22&quot;&gt;10.1097/MS9.00000000000047294167581512889312)&lt;/searchLink&gt;&lt;br /&gt;Ellington TD, Momin B, Wilson RJ, et al. Incidence and mortality of cancers of the biliary tract, gallbladder, and liver by sex, age, race/ethnicity, and stage at diagnosis: United States, 2013 to 2017. Cancer Epidemiol Biomarkers Prev. 2013;30(9):1607–14. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1158%2F1055-9965%2EEPI-21-0265%22&quot;&gt;10.1158/1055-9965.EPI-21-0265)&lt;/searchLink&gt;&lt;br /&gt;Raja A, Raja S, Amin SB, et al. Temporal trends in hypertension related end stage renal disease mortality rates: an analysis of gender, race/ethnicity, and geographic disparities in the United States. Front Nephrol. 2023;3:1339312. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E3389%2Ffneph%2E2023%2E133931238288382%22&quot;&gt;10.3389/fneph.2023.133931238288382)&lt;/searchLink&gt;&lt;br /&gt;Kim HJ, Fay MP, Feuer EJ, et al. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med. 2000;19(3):335–51. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1002%2F%28SICI%291097-0258%2820000215%2919%3A3%26lt%3B335%3A%3AAID-SIM336%26gt%3B3%2E0%2ECO%3B2-Z10649300%22&quot;&gt;10.1002/(SICI)1097-0258(20000215)19:3&amp;lt;335::AID-SIM336&amp;gt;3.0.CO;2-Z10649300)&lt;/searchLink&gt;&lt;br /&gt;Martin AN, Chan NW, Cheung DC, et al. A guide to large data sets for population-based cancer research: strengths, limitations, and pitfalls. Cancer. 2024;130(22):3802–14. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2210%2E1002%2Fcncr%2E3553539158578%22&quot;&gt;10.1002/cncr.3553539158578)&lt;/searchLink&gt;
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: &lt;i&gt;Keywords: &lt;/i&gt;Age-adjusted mortality rate; Biliary tract cancers; CDC WONDER; Cholangiocarcinoma; Gallbladder cancer; Joinpoint regression; Mortality
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: &lt;i&gt;Date Created: &lt;/i&gt;20260724 &lt;i&gt;Date Completed: &lt;/i&gt;20260724 &lt;i&gt;Latest Revision: &lt;/i&gt;20260724
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260725
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1007/s12029-026-01537-4
– Name: AN
  Label: PMID
  Group: ID
  Data: 42498813
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42498813
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s12029-026-01537-4
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: United States epidemiology
        Type: general
      – SubjectFull: Cholangiocarcinoma mortality
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Aged
        Type: general
      – SubjectFull: Middle Aged
        Type: general
      – SubjectFull: Adult
        Type: general
      – SubjectFull: Aged, 80 and over
        Type: general
      – SubjectFull: Biliary Tract Neoplasms mortality
        Type: general
      – SubjectFull: Mortality trends
        Type: general
    Titles:
      – TitleFull: Mortality Trends of Biliary Tract Cancers in the United States, 1999-2023: a CDC-WONDER Analysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Chen J
      – PersonEntity:
          Name:
            NameFull: Yang G
      – PersonEntity:
          Name:
            NameFull: Sun X
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 24
              M: 07
              Text: 2026 Jul 24
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1941-6636
          Numbering:
            – Type: volume
              Value: 57
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of gastrointestinal cancer
              Type: main
ResultId 1