Academic Journal
Investigating the role of CpG islands and DNA methylation at 3'UTRs in cancer.
| Τίτλος: | Investigating the role of CpG islands and DNA methylation at 3'UTRs in cancer. |
|---|---|
| Συγγραφείς: | Wilson C; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Kanhere A; Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK a.kanhere@liverpool.ac.uk. |
| Πηγή: | Life science alliance [Life Sci Alliance] 2026 Jul 24; Vol. 9 (10). Date of Electronic Publication: 2026 Jul 24 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Life Science Alliance, LLC Country of Publication: United States NLM ID: 101728869 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2575-1077 (Electronic) Linking ISSN: 25751077 NLM ISO Abbreviation: Life Sci Alliance Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Woodbury, NY] : Life Science Alliance, LLC, [2018]- |
| Ιατρικοί όροι (MeSH): | CpG Islands*/genetics , DNA Methylation*/genetics , 3' Untranslated Regions*/genetics , Neoplasms*/genetics, Promoter Regions, Genetic/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Epigenesis, Genetic/genetics ; Humans |
| Περίληψη: | DNA methylation is one of the most important epigenetic processes that regulates gene expression. Although the human genome is predominantly methylated, CpG-rich regions known as CpG islands (CGIs) are typically unmethylated and are often sites of transcriptional control. Although the importance of CGIs and DNA methylation at the promoters is well understood, the significance of CGIs at the 3' ends remains largely unexplored. In this study, we characterised CGIs overlapping 3' untranslated regions (3'UTRs), compared them with CGIs located at the promoters, and examined their association with gene expression in cancer. We found that 3% of CGIs overlap 3'UTRs and have no annotated promoters in the vicinity. Unlike promoter CGIs, 3'UTR CGIs are shorter, less CpG-dense, but evolutionarily conserved. Although promoter CGIs typically stay unmethylated, those in 3'UTRs are often methylated and enriched for transcription factors like ZFP57, which target methylated motifs. These regions are linked to cancer signalling pathways, and their differential methylation in tumours correlates with gene expression changes, suggesting an underexplored regulatory role in cancer. (© 2026 Wilson and Kanhere.) |
| Substance Nomenclature: | 0 (3' Untranslated Regions) |
| Entry Date(s): | Date Created: 20260724 Date Completed: 20260724 Latest Revision: 20260727 |
| Update Code: | 20260727 |
| PubMed Central ID: | PMC13401056 |
| DOI: | 10.26508/lsa.202503234 |
| PMID: | 42498499 |
| Βάση Δεδομένων: | MEDLINE |
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