Academic Journal
A Comprehensive Evaluation of Adiposity Indices on 20-Year Cumulative Incidence of Type 2 Diabetes: The ATTICA Cohort Study (2002-2022).
| Τίτλος: | A Comprehensive Evaluation of Adiposity Indices on 20-Year Cumulative Incidence of Type 2 Diabetes: The ATTICA Cohort Study (2002-2022). |
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| Συγγραφείς: | Kechagia I; Department of Nutrition and Dietetics, School of Health Sciences & Education, Harokopio University, Athens, Greece.; Department of Clinical Dietetics-Nutrition, HYGEIA Hospital, Athens, Greece., Giannakopoulou SP; Department of Nutrition and Dietetics, School of Health Sciences & Education, Harokopio University, Athens, Greece., Barkas F; Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece., Yannakoulia M; Department of Nutrition and Dietetics, School of Health Sciences & Education, Harokopio University, Athens, Greece., Liberopoulos E; First Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece., Sfikakis PP; First Department of Propaedeutic and Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece., Pitsavos C; First Cardiology Clinic, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece., Panagiotakos D; Department of Nutrition and Dietetics, School of Health Sciences & Education, Harokopio University, Athens, Greece. |
| Πηγή: | Clinical obesity [Clin Obes] 2026 Aug; Vol. 16 (4), pp. e70100. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101560587 Publication Model: Print Cited Medium: Internet ISSN: 1758-8111 (Electronic) Linking ISSN: 17588103 NLM ISO Abbreviation: Clin Obes Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford : Wiley-Blackwell |
| Ιατρικοί όροι (MeSH): | Diabetes Mellitus, Type 2*/epidemiology , Diabetes Mellitus, Type 2*/etiology , Adiposity*/physiology , Obesity*/complications , Obesity*/epidemiology, Greece/epidemiology ; Humans ; Female ; Adult ; Male ; Incidence ; Middle Aged ; Cohort Studies ; Risk Factors ; Body Mass Index |
| Περίληψη: | The aim of this study was to evaluate the association between indices of adiposity and 20-year cumulative incidence of type 2 diabetes (T2D) among apparently healthy adults participating in the ATTICA cohort study (2002-2022). The present analysis included data from 2000 individuals free of atherosclerotic cardiovascular disease (ASCVD) and T2D at baseline (age 43 ± 13 years; 51% women). Sociodemographic, anthropometric, lifestyle, clinical, and biochemical parameters were collected at baseline and follow-up examinations. Obesity-related anthropometric indices, in terms of total and central adiposity, along with dysfunctional adipose tissue-related indices, were measured. The 20-year cumulative incidence of T2D was 26.3% (95% CI [24.4%, 28.3%]). All indices were independently associated with the 20-year incidence of T2D, with an overall predictive accuracy of approximately 75%. With the exception of LAP (lipid accumulation product), all indices reflecting adipose tissue dysfunction demonstrated moderate discriminative accuracy for incident T2D (C-statistic varied between 0.70 and 0.80) over the 20-year follow-up period, in line with obesity-related anthropometric indices assessing total and central adiposity (C-statistic 0.70-0.80). Obesity-related anthropometric indices as well as dysfunctional adipose tissue-related indices were moderately predictive of long-term T2D onset, highlighting the complex role of increased body weight on glucose metabolism. (© 2026 The Author(s). Clinical Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation.) |
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| Grant Information: | Hellenic Cardiological Society; Hellenic Atherosclerosis Society |
| Contributed Indexing: | Keywords: adiposity indices; dysfunctional adipose tissue; obesity; type 2 diabetes |
| Entry Date(s): | Date Created: 20260724 Date Completed: 20260724 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13397539 |
| DOI: | 10.1111/cob.70100 |
| PMID: | 42495893 |
| Βάση Δεδομένων: | MEDLINE |
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