Academic Journal
View in EDS
Linked Full Text

Zebrafish as a versatile model in biomedical research, from disease modeling to regenerative medicine: a review.

Bibliographic Details
Title: Zebrafish as a versatile model in biomedical research, from disease modeling to regenerative medicine: a review.
Authors: Heydari SF; Tissue Engineering and Regenerative Medicine Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran., Abedi A; Tissue Engineering and Regenerative Medicine Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran., Mirnejad AM; Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Kooshki H; Nanobiotechnology Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran., Moosazadeh Moghaddam M; Tissue Engineering and Regenerative Medicine Research Center, New Health Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. mm.genetics@gmail.com.
Source: Fish physiology and biochemistry [Fish Physiol Biochem] 2026 Jul 23; Vol. 52 (4). Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 100955049 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-5168 (Electronic) Linking ISSN: 09201742 NLM ISO Abbreviation: Fish Physiol Biochem Subsets: MEDLINE
Imprint Name(s): Publication: Dordrecht ; Boston : Kluwer Academic Publishers
Original Publication: Amsterdam ; Berkeley : Kugler, 1986-
MeSH Terms: Zebrafish*/physiology , Zebrafish*/genetics , Regenerative Medicine* , Disease Models, Animal* , Biomedical Research*, Animals ; Humans ; Biocompatible Materials
Abstract: Zebrafish are an effective animal model widely utilized in biomedical research. They are known for their rapid reproduction and substantial genetic similarity to humans. Their transparent embryos directly enable the visualization of developmental processes and disease progression. This makes zebrafish invaluable for studying a broad range of human diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. Compared with other vertebrate models, zebrafish offer several advantages, including ease of genome editing, cost-effective maintenance, and suitability for high-throughput drug screening. Recent advancements have expanded the use of zebrafish in disease modeling and regenerative medicine, providing deeper insights into the genetic and cellular mechanisms underlying human pathologies. Zebrafish provide a robust platform for evaluating the safety, efficacy, and regenerative potential of both natural and synthetic biomaterials, including hydroxyapatite, bioactive glass nanoparticles, and bioceramics. This capability facilitates the creation of artificial tissues that closely resemble native structures. Additionally, integrating artificial intelligence technologies has improved automated data analysis and phenotyping in zebrafish studies, enhancing both accuracy and throughput. This review highlights current applications of zebrafish in disease modeling, drug discovery, regenerative medicine, and biomaterial assessment, emphasizing their evolving role as a versatile preclinical platform supported by advanced genetic and computational tools.
(© 2026. The Author(s), under exclusive licence to Springer Nature B.V.)
Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable for this article. This article is without human or animal-based experiments. Consent for publication: The manuscript does not contain the individual person’s data. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable.
References: Adhish M, Manjubala I (2023) Effectiveness of zebrafish models in understanding human diseases—a review of models. Heliyon. https://doi.org/10.1016/j.heliyon.2023.e14557. (PMID: 10.1016/j.heliyon.2023.e145573695060510025926)
Aghamollaei H, Hashemi H, Fallahtafti M, Daryabari S-H, Khabazkhoob M, Jadidi K (2024) Applications of SMILE-extracted lenticules in ophthalmology. Int J Ophthalmol 17(1):173. (PMID: 382399481075465810.18240/ijo.2024.01.23)
Agrawal R, Singh S, Saxena KK, Buddhi D (2023) A role of biomaterials in tissue engineering and drug encapsulation. Proc Inst Mech Eng E J Process Mech Eng. https://doi.org/10.1177/09544089221150740. (PMID: 10.1177/09544089221150740)
Ai X, Ye Z, Xiao C, Zhong J, Lancman JJ, Chen X et al (2022) Clinically relevant orthotopic xenograft models of patient-derived glioblastoma in zebrafish. Dis Model Mech 15(4). (PMID: 35199829906651410.1242/dmm.049109)
Altyar AE, El-Sayed A, Abdeen A, Piscopo M, Mousa SA, Najda A et al (2023) Future regenerative medicine developments and their therapeutic applications. Biomed Pharmacother 158. (PMID: 3653886110.1016/j.biopha.2022.114131)
Angom RS, Wang Y, Wang E, Dutta S, Mukhopadhyay D (2023) Conditional, tissue-specific CRISPR/Cas9 vector system in zebrafish reveal the role of neuropilin-1b in heart regeneration. bioRxiv. 2023.01. 16.524222.
Arjmand B, Tayanloo-Beik A, Foroughi Heravani N, Alaei S, Payab M, Alavi-Moghadam S et al (2020) Zebrafish for personalized regenerative medicine; a more predictive humanized model of endocrine disease. Front Endocrinol 11:396. (PMID: 10.3389/fendo.2020.00396)
Azhari H, Younus M, Hook SM, Boyd BJ, Rizwan SB (2021) Cubosomes enhance drug permeability across the blood–brain barrier in zebrafish. Int J Pharm 600. (PMID: 3367592610.1016/j.ijpharm.2021.120411)
Bailone RL, Fukushima HCS, Ventura Fernandes BH, De Aguiar LK, Corrêa T, Janke H et al (2020) Zebrafish as an alternative animal model in human and animal vaccination research. Lab Anim Res 36:1–10. (PMID: 10.1186/s42826-020-00042-4)
Barbosa GR, de Souza AM, Silva PF, Fávero CS, de Oliveira JL, Carvalho HF et al (2025) Zebrafish as a model for translational immuno-oncology. Journal of Personalized Medicine 15(7):304. (PMID: 407104211229863810.3390/jpm15070304)
Bedell VM, Dubey P, Lee HB, Bailey DS, Anderson JL, Jamieson-Lucy A et al (2025) Zebrafishology, study design guidelines for rigorous and reproducible data using zebrafish. Commun Biol 8(1). (PMID: 10.1038/s42003-025-07496-z4036075012075475)
Bharadwaj A (2021) editor An overview on biomaterials and its applications in medical science. IOP conference series: materials science and engineering; IOP Publishing.
Bozzer S, De Maso L, Grimaldi MC, Capolla S, Dal Bo M, Toffoli G et al (2022) Zebrafish: a useful animal model for the characterization of drug-loaded polymeric NPs. Biomedicines 10(9):2252. (PMID: 36140353949625610.3390/biomedicines10092252)
Bragato C, Mazzotta R, Persico A, Bengalli R, Ornelas M, Gomes F et al (2024) Biocompatibility analysis of bio-based and synthetic silica nanoparticles during early zebrafish development. Int J Mol Sci 25(10). (PMID: 387915661112196110.3390/ijms25105530)
Burgess HA, Burton EA (2023) A critical review of zebrafish neurological disease models− 1. The premise: neuroanatomical, cellular and genetic homology and experimental tractability. Oxf Open Neurosci 2. (PMID: 376497771046450610.1093/oons/kvac018)
Carey CM, Hollins HL, Schmid AV, Gagnon JA (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biol Open 13(4). (PMID: 385261881100773610.1242/bio.060156)
Cassar S, Adatto I, Freeman JL, Gamse JT, Iturria I, Lawrence C et al (2019) Use of zebrafish in drug discovery toxicology. Chem Res Toxicol 33(1):95–118. (PMID: 31625720716267110.1021/acs.chemrestox.9b00335)
Chaoul V, Dib E-Y, Bedran J, Khoury C, Shmoury O, Harb F et al (2023) Assessing drug administration techniques in zebrafish models of neurological disease. Int J Mol Sci 24(19). (PMID: 378343451057332310.3390/ijms241914898)
Cui C, Wang L-F, Huang S-B, Zhao P, Chen Y-Q, Wu Y-B et al (2021) Adequate expression of neuropeptide Y is essential for the recovery of zebrafish motor function following spinal cord injury. Exp Neurol 345. (PMID: 3436380710.1016/j.expneurol.2021.113831)
d’Amora M, Giordani S (2018) The utility of zebrafish as a model for screening developmental neurotoxicity. Front Neurosci 12. (PMID: 30618594630533110.3389/fnins.2018.00976)
Dash SN, Patnaik L (2023) Flight for fish in drug discovery: a review of zebrafish-based screening of molecules. Biol Lett 19(8). (PMID: 375287291039442410.1098/rsbl.2022.0541)
de Assis Valadares LP, Lima LCO, de Saboia-Morais SMT, Arantes TM, Cristovan FH, da Silva NM et al (2023) Embryotoxicity of silica nanoparticles in the drug delivery of domperidone in zebrafish. Aquat Toxicol 258. (PMID: 3695815410.1016/j.aquatox.2023.106454)
de Souza AM, Araujo-Silva H, Costa AM, Rossi AL, Rossi AM, Granjeiro JM et al (2023) Embryotoxicity and visual-motor response of functionalized nanostructured hydroxyapatite-based biomaterials in zebrafish (Danio rerio). Chemosphere 313. (PMID: 3650291310.1016/j.chemosphere.2022.137519)
Devine MJ, Plun-Favreau H, Wood NW (2011) Parkinson’s disease and cancer: two wars, one front. Nat Rev Cancer 11(11):813–823. (PMID: 10.1038/nrc3150)
Dong G, Wang N, Xu T, Liang J, Qiao R, Yin D et al (2023) Deep learning-enabled morphometric analysis for toxicity screening using zebrafish larvae. Environ Sci Technol 57(46):18127–18138. (PMID: 3697126610.1021/acs.est.3c00593)
Engeszer RE, Patterson LB, Rao AA, Parichy DM (2007) Zebrafish in the wild: a review of natural history and new notes from the field. Zebrafish 4(1):21–40. (PMID: 1804194010.1089/zeb.2006.9997)
Fallah Tafti M, Faghihi S (2023) Cartilage tissue engineering: advances and frontiers. Cartilage: from biology to biofabrication. Springer, pp 255–287. (PMID: 10.1007/978-981-99-2452-3_9)
Fallah Tafti M, Aghamollaei H, Moosazadeh Moghaddam M, Jadidi K, Faghihi S (2023) An inspired microenvironment of cell replicas to induce stem cells into keratocyte-like dendritic cells for corneal regeneration. Sci Rep 13(1):15012. (PMID: 10.1038/s41598-023-42359-93769688310495344)
Fan Y-L, Hsu F-R, Wang Y, Liao L-D (2023) Unlocking the potential of zebrafish research with artificial intelligence: advancements in tracking, processing, and visualization. Med Biol Eng Comput 61(11):2797–2814. (PMID: 10.1007/s11517-023-02903-137558927)
Gamble JT, Elson DJ, Greenwood JA, Tanguay RL, Kolluri SK (2021) The zebrafish xenograft models for investigating cancer and cancer therapeutics. Biology (Basel) 10(4). (PMID: 338048308063817)
Hernández-Silva D, Alcaraz-Pérez F, Pérez-Sánchez H, Cayuela ML (2023) Virtual screening and zebrafish models in tandem, for drug discovery and development. Expert Opin Drug Discov 18(8):903–915. (PMID: 3638340510.1080/17460441.2022.2147503)
Hong Y, Luo Y (2021) Zebrafish model in ophthalmology to study disease mechanism and drug discovery. Pharmaceuticals (Basel) 14(8). (PMID: 34451814840059310.3390/ph14080716)
Hoo JY, Kumari Y, Shaikh MF, Hue SM, Goh BH (2016) Zebrafish: a versatile animal model for fertility research. BioMed Res Int. https://doi.org/10.1155/2016/9732780. (PMID: 10.1155/2016/9732780275560454983327)
Hoseini Tavassol Z, Ejtahed H-S, Hasani-Ranjbar S (2024) Insights from the potential impact of pasteurized Akkermansia muciniphila in zebrafish models of obesity and diabetes. Journal of Diabetes & Metabolic Disorders. 1–3.
Howe DG, Bradford YM, Eagle A, Fashena D, Frazer K, Kalita P et al (2017) The Zebrafish Model Organism Database: new support for human disease models, mutation details, gene expression phenotypes and searching. Nucleic Acids Res 45(D1):D758–D768. (PMID: 2789958210.1093/nar/gkw1116)
Irion U, Singh AP, Nüsslein-Volhard C (2016) The developmental genetics of vertebrate color pattern formation: lessons from zebrafish. Curr Top Dev Biol 117:141–169. (PMID: 2696997610.1016/bs.ctdb.2015.12.012)
Jadidi K, Tafti MF, Dianat MH, Rafati S, Ghiasi M, Rafati N et al (2024) Acellular human amniotic membrane: a safe and stable matrix for corneal stromal regeneration. Colloids Surf A Physicochem Eng Asp 690. (PMID: 10.1016/j.colsurfa.2024.133745)
Kandaswamy K, Panda SP, Subramanian R, Khan H, Shaik MR, Hussain SA et al (2024) Synergistic berberine chloride and curcumin-loaded nanofiber therapies against methicillin-resistant Staphylococcus aureus infection: augmented immune and inflammatory responses in zebrafish wound healing. Int Immunopharmacol 140. (PMID: 3912160910.1016/j.intimp.2024.112856)
Kiper K, Freeman JL (2022) Use of zebrafish genetic models to study etiology of the amyloid-beta and neurofibrillary tangle pathways in Alzheimer’s disease. Curr Neuropharmacol 20(3):524–539. (PMID: 34030617960823310.2174/1570159X19666210524155944)
Kong L, Chen Q, Campbell F, Snaar‐Jagalska E, Kros A (2020) Light‐triggered cancer cell specific targeting and liposomal drug delivery in a zebrafish xenograft model. Adv Healthc Mater 9(6). (PMID: 10.1002/adhm.201901489)
Laird AS, Mackovski N, Rinkwitz S, Becker TS, Giacomotto J (2016) Tissue-specific models of spinal muscular atrophy confirm a critical role of SMN in motor neurons from embryonic to adult stages. Hum Mol Genet 25(9):1728–1738. (PMID: 2690860610.1093/hmg/ddw044)
Lam S, Chua H, Gong Z, Lam T, Sin Y (2004) Development and maturation of the immune system in zebrafish, Danio rerio: a gene expression profiling, in situ hybridization and immunological study. Dev Comp Immunol 28(1):9–28. (PMID: 1296297910.1016/S0145-305X(03)00103-4)
Lane S, More LA, Asnani A (2021) Zebrafish models of cancer therapy-induced cardiovascular toxicity. Journal of Cardiovascular Development and Disease 8(2):8. (PMID: 33499052791126610.3390/jcdd8020008)
Larijani B, Hamidpour SK, Tayanloo-Beik A, Shahbazbadr A, Yavari H, Namazi N (2021) An overview of zebrafish modeling methods in drug discovery and development. Cell Biology and Translational Medicine, Volume 16: Stem Cells in Tissue Regeneration, Therapy and Drug Discovery. pp 145–69.
Lee KY, Jang GH, Byun CH, Jeun M, Searson PC, Lee KH (2017) Zebrafish models for functional and toxicological screening of nanoscale drug delivery systems: promoting preclinical applications. Biosci Rep 37(3). (PMID: 28515222546325810.1042/BSR20170199)
Li X, Li M (2023) The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents. Med Res Rev 43(1):212–236. (PMID: 3602917810.1002/med.21924)
Liu S, Yu J-M, Gan Y-C, Qiu X-Z, Gao Z-C, Wang H et al (2023) Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications. Mil Med Res 10(1). (PMID: 3697816710047482)
Meng L, Zhao P, Jiang Y, You J, Xu Z, Yu K et al (2024) Extracellular and intracellular effects of bioactive glass nanoparticles on osteogenic differentiation of bone marrow mesenchymal stem cells and bone regeneration in zebrafish osteoporosis model. Acta Biomater 174:412–427. (PMID: 3804007710.1016/j.actbio.2023.11.037)
Mishra YK, Verma SK, Nandi A, Sinha A, Patel P, Jha E et al (2021) Zebrafish (Danio rerio) as an ecotoxicological model for nanomaterial induced toxicity profiling. Precision Nanomedicine 4(1):750–782.
Moghaddam MM, Bonakdar S, Shariatpanahi MR, Shokrgozar MA, Faghihi S (2019) The effect of physical cues on the stem cell differentiation. Curr Stem Cell Res Ther 14(3):268–277. (PMID: 3058888810.2174/1574888X14666181227120706)
Mongera A, Pochitaloff M, Gustafson HJ, Stooke-Vaughan GA, Rowghanian P, Kim S et al (2023) Mechanics of the cellular microenvironment as probed by cells in vivo during zebrafish presomitic mesoderm differentiation. Nat Mater 22(1):135–43. (PMID: 10.1038/s41563-022-01433-936577855)
Mosaddad SA, Salari Y, Amookhteh S, Soufdoost RS, Seifalian A, Bonakdar S et al (2021) Response to mechanical cues by interplay of YAP/TAZ transcription factors and key mechanical checkpoints of the cell: a comprehensive review. Cell Physiol Biochem 55(1):33–60. (PMID: 3347490610.33594/000000325)
Naomi R, Bahari H, Yazid MD, Embong H, Othman F (2021) Zebrafish as a model system to study the mechanism of cutaneous wound healing and drug discovery: advantages and challenges. Pharmaceuticals (Basel) 14(10). (PMID: 34681282853957810.3390/ph14101058)
Nasiadka A, Clark MD (2012) Zebrafish breeding in the laboratory environment. ILAR J 53(2):161–168. (PMID: 2338234710.1093/ilar.53.2.161)
Nosrati H, Fallah Tafti M, Aghamollaei H, Bonakdar S, Moosazadeh Moghaddam M (2024) Directed differentiation of adipose-derived stem cells using imprinted cell-like topographies as a growth factor-free approach. Stem Cell Reviews and Reports. 1–30.
Patel UD, Srinivasan M (2024) Zebrafish: an animal model in biomedical research. Animal Models in Research: Principles and Practice. Springer, pp 131–67.
Pitchai A, Rajaretinam RK, Freeman JL (2019) Zebrafish as an emerging model for bioassay-guided natural product drug discovery for neurological disorders. Medicines 6(2):61. (PMID: 31151179663171010.3390/medicines6020061)
Pott A, Rottbauer W, Just S (2020) Streamlining drug discovery assays for cardiovascular disease using zebrafish. Expert Opin Drug Discov 15(1):27–37. (PMID: 3157002010.1080/17460441.2020.1671351)
Reimunde P, Pensado-López A, Carreira Crende M, Lombao Iglesias V, Sánchez L, Torrecilla-Parra M et al (2021) Cellular and molecular mechanisms underlying glioblastoma and zebrafish models for the discovery of new treatments. Cancers (Basel) 13(5). (PMID: 33802571796172610.3390/cancers13051087)
Rittidach T, Sillapaprayoon S, Chantho V, Pimtong W, Charoenphandhu N, Thongbunchoo J et al (2023) Investigation on the physical properties and biocompatibility of zirconia–alumina-silicate@ diopside composite materials and its in vivo toxicity study in embryonic zebrafish. RSC Adv 13(44):30575–30585. (PMID: 378597781058326210.1039/D3RA04555B)
Roohi TF, Faizan S, Shaikh MF, Krishna KL, Mehdi S, Kinattingal N et al (2024) Beyond drug discovery: exploring the physiological and methodological dimensions of zebrafish in diabetes research. Exp Physiol 109(6):847–872. (PMID: 382799511114017610.1113/EP091587)
Saleem S, Kannan RR (2021) Zebrafish: a promising real-time model system for nanotechnology-mediated neurospecific drug delivery. Nanoscale Res Lett 16:1–14. (PMID: 10.1186/s11671-021-03592-1)
Sharma A, Saneja A (2022) Zebrafish as a powerful alternative model organism for preclinical investigation of nanomedicines. Drug Discovery Today 27(5):1513–1522. (PMID: 3519292510.1016/j.drudis.2022.02.011)
Tabarés-Seisdedos R, Rubenstein JL (2013) Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders. Nat Rev Neurosci 14(4):293–304. (PMID: 10.1038/nrn346423511909)
Tafti MF, Aghamollaei H, Moghaddam MM, Jadidi K, Alio JL, Faghihi S (2022) Emerging tissue engineering strategies for the corneal regeneration. J Tissue Eng Regen Med 16(8):683–706. (PMID: 3558547910.1002/term.3309)
Tavares B, Lopes SS (2013) The importance of zebrafish in biomedical research. Acta Med Port 26(5):583–592. (PMID: 2419209910.20344/amp.4628)
Teame T, Zhang Z, Ran C, Zhang H, Yang Y, Ding Q et al (2019) The use of zebrafish (Danio rerio) as biomedical models. Anim Front 9(3):68–77. (PMID: 32002264695198710.1093/af/vfz020)
Tithito T, Sillapaprayoon S, Pimtong W, Thongbunchoo J, Charoenphandhu N, Krishnamra N et al (2023) Development of biomaterials based on biomimetic trace elements Co-doped hydroxyapatite: physical, in vitro osteoblast-like cell growth and in vivo cytotoxicity in zebrafish studies. Nanomaterials (Basel) 13(2). (PMID: 36678008986668010.3390/nano13020255)
Tonon F, Grassi G (2023) Zebrafish as an experimental model for human disease. MDPI, p 8771.
Tsang B, Zahid H, Ansari R, Lee RC-Y, Partap A, Gerlai R (2017) Breeding zebrafish: a review of different methods and a discussion on standardization. Zebrafish 14(6):561–573. (PMID: 2887303710.1089/zeb.2017.1477)
Usai A, Di Franco G, Colucci P, Pollina LE, Vasile E, Funel N et al (2020) A model of a zebrafish avatar for co-clinical trials. Cancers 12(3):677. (PMID: 32183229714006310.3390/cancers12030677)
Vimalraj S, Yuvashree R, Hariprabu G, Subramanian R, Murali P, Veeraiyan DN et al (2021) Zebrafish as a potential biomaterial testing platform for bone tissue engineering application: a special note on chitosan based bioactive materials. Int J Biol Macromol 175:379–395. (PMID: 3355640110.1016/j.ijbiomac.2021.02.005)
Vimalraj S, Govindarajan D, Sudhakar S, Suresh R, Palanivel P, Sekaran S (2024) Chitosan derived chito-oligosaccharides promote osteoblast differentiation and offer anti-osteoporotic potential: Molecular and morphological evidence from a zebrafish model. Int J Biol Macromol 259. (PMID: 3819955110.1016/j.ijbiomac.2024.129250)
Wei X, Wang W, Yin Q, Li H, Ahmed A, Ullah R et al (2024) In vivo chemical screening in zebrafish embryos identified FDA-approved drugs that induce differentiation of acute myeloid leukemia cells. Int J Mol Sci 25(14). (PMID: 390630391127704410.3390/ijms25147798)
Wu S-Y, Chou H-Y, Tsai H-C, Anbazhagan R, Yuh C-H, Yang JM et al (2020) Amino acid-modified PAMAM dendritic nanocarriers as effective chemotherapeutic drug vehicles in cancer treatment: a study using zebrafish as a cancer model. RSC Adv 10(35):20682–20690. (PMID: 35517745905429510.1039/D0RA01589J)
Wu X, Hua X, Xu K, Song Y, Lv T (2023) Zebrafish in Lung Cancer Research Cancers 15(19):4721. (PMID: 3783541510571557)
Yang J, Shimada Y, Olsthoorn RC, Snaar-Jagalska BE, Spaink HP, Kros A (2016) Application of coiled coil peptides in liposomal anticancer drug delivery using a zebrafish xenograft model. ACS Nano 10(8):7428–7435. (PMID: 2750466710.1021/acsnano.6b01410)
Zang L, Shimada Y, Nishimura N (2017) Development of a novel zebrafish model for type 2 diabetes mellitus. Sci Rep 7(1). (PMID: 10.1038/s41598-017-01432-w284692505431185)
Zeng C-W, Tsai H-J (2023) The promising role of a zebrafish model employed in neural regeneration following a spinal cord injury. Int J Mol Sci 24(18). (PMID: 377622401053078310.3390/ijms241813938)
Zeng C-W, Sheu J-C, Tsai H-J (2022) Hypoxia-responsive subtype cells differentiate into neurons in the brain of zebrafish embryos exposed to hypoxic stress. Cell Transplant 31. (PMID: 35225023889497310.1177/09636897221077930)
Contributed Indexing: Keywords: Animal model; Artificial intelligence; Disease modeling; Drug screening; Patient-derived xenograft; Regenerative medicine; Zebrafish
Substance Nomenclature: 0 (Biocompatible Materials)
Entry Date(s): Date Created: 20260723 Date Completed: 20260723 Latest Revision: 20260723
Update Code: 20260723
DOI: 10.1007/s10695-026-01748-3
PMID: 42489951
Database: MEDLINE
Description
ISSN:1573-5168
DOI:10.1007/s10695-026-01748-3