Academic Journal
Mammary adipocyte plasticity and epithelial crosstalk: roles in development, remodeling, and disease.
| Τίτλος: | Mammary adipocyte plasticity and epithelial crosstalk: roles in development, remodeling, and disease. |
|---|---|
| Συγγραφείς: | Chen P; Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Liao Y; Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. yunjun1000@sina.com., Cai J; Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. drjunrongcai@outlook.com. |
| Πηγή: | Reviews in endocrine & metabolic disorders [Rev Endocr Metab Disord] 2026 Oct; Vol. 27 (5), pp. 1023-1040. Date of Electronic Publication: 2026 Jul 23. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Germany NLM ID: 100940588 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2606 (Electronic) Linking ISSN: 13899155 NLM ISO Abbreviation: Rev Endocr Metab Disord Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2005-: Heidelberg : Springer Original Publication: Boston : Kluwer Academic Publishers, c2000- |
| Ιατρικοί όροι (MeSH): | Adipocytes*/physiology , Adipocytes*/metabolism , Mammary Glands, Human*/metabolism , Mammary Glands, Human*/cytology , Mammary Glands, Human*/growth & development , Mammary Glands, Human*/physiology , Cell Plasticity*/physiology , Epithelial Cells*/physiology , Mammary Glands, Animal*, Humans ; Animals ; Female |
| Περίληψη: | The mammary gland is a composite organ in which epithelial ducts and alveoli develop within a specialized adipose-rich stroma. Although mammary biology has traditionally been interpreted through an epithelium-centered framework, increasing evidence indicates that mammary adipocytes actively shape mammary development, reproductive remodeling, and disease susceptibility. Across puberty, pregnancy, lactation, and involution, mammary adipocytes undergo dynamic changes in cellular state, morphology, lipid handling, and stromal interactions, reflecting fate-related, phenotypic, and metabolic plasticity. Through adipokines, growth factors, metabolic substrates, extracellular matrix (ECM)-associated mechanical cues, and immune-inflammatory networks, mammary adipocytes influence epithelial behavior and tissue remodeling. Conversely, epithelial expansion, secretory differentiation, and post-weaning regression reshape the adipose-rich stromal niche. Dysregulation of this reciprocal adipose-epithelial ecosystem may contribute to aberrant tissue expansion, local estrogenic or inflammatory amplification, impaired adipose support, and tumor-permissive remodeling. Here, we review stage-specific epithelial-adipocyte crosstalk during mammary development, define mammary adipocyte plasticity across fate-related and functional dimensions, and discuss its relevance to benign breast disorders, tumor-associated remodeling, and disease susceptibility. (© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Competing Interests: | Declarations. Ethics approval: Not applicable. This article is a narrative review and does not contain any studies with human participants or animals performed by the authors. Consent to participate: Not applicable. Consent to publish: Not applicable. Competing interests: The authors declare no competing interests. |
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| Grant Information: | 81901976, 82472585, 82372544 National Natural Science Foundation of China; 2023A1515011741 Natural Science Foundation of Guangdong Province; 2023A04J2348 Guangzhou Municipal Science and Technology Project; K50906009, K50304020 Nanfang Hospital's Outstanding Young Talent Cultivation Program; K51701101 Nanfang Hospital's Scientific Research Development Fund |
| Contributed Indexing: | Keywords: Adipocyte plasticity; Adipose tissue; Breast cancer; Breast development; Epithelial–stromal crosstalk; Mammary gland |
| Entry Date(s): | Date Created: 20260723 Date Completed: 20260926 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1007/s11154-026-10065-2 |
| PMID: | 42489854 |
| Βάση Δεδομένων: | MEDLINE |
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