Academic Journal
Evaluation of the early effects of peptide-containing agents in sensitivity treatment regarding their structural, morphological, and elemental changes in dentin tissue and their penetration efficacy.
| Τίτλος: | Evaluation of the early effects of peptide-containing agents in sensitivity treatment regarding their structural, morphological, and elemental changes in dentin tissue and their penetration efficacy. |
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| Συγγραφείς: | Ozdemir T; Izmir Katip Celebi University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey., Savas S; Izmir Katip Celebi University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey., Izgi EK; Izmir Katip Celebi University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey. |
| Πηγή: | Journal of applied oral science : revista FOB [J Appl Oral Sci] 2026 Jul 17; Vol. 34, pp. e20260127. Date of Electronic Publication: 2026 Jul 17 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article; Evaluation Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Faculdade de Odontologia de Bauru, USP Country of Publication: Brazil NLM ID: 101189774 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-7765 (Electronic) Linking ISSN: 16787757 NLM ISO Abbreviation: J Appl Oral Sci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bauru, SP : Faculdade de Odontologia de Bauru, USP, [2003]- |
| Ιατρικοί όροι (MeSH): | Dentin*/drug effects , Dentin*/chemistry , Dentin*/ultrastructure , Dentin Desensitizing Agents*/pharmacology , Dentin Desensitizing Agents*/chemistry , Dentin Sensitivity*/drug therapy , Peptides*/pharmacology , Peptides*/chemistry , Caseins*/chemistry , Caseins*/pharmacology, Surface Properties/drug effects ; Hardness/drug effects ; Dentin Permeability/drug effects ; Saliva, Artificial/chemistry ; Humans ; Time Factors ; Microscopy, Electron, Scanning ; Materials Testing ; Reproducibility of Results ; Reference Values ; Spectrometry, X-Ray Emission ; Random Allocation ; Microscopy, Confocal ; Hardness Tests ; Treatment Outcome ; Statistics, Nonparametric |
| Περίληψη: | Correspondence: Ebru Kucukyılmaz Izgı - Izmir Katip Celebi University - Faculty of Dentistry - Department of Pediatric Dentistry - Cigli - Izmir - Turkey - E-mail: ebrukucukyilmaz@hotmail.com - Tel: +902323524040. Purpose: This study aimed to evaluate the effects of various therapeutic agents on dentin tissue in the management of dentin hypersensitivity. Methodology: Overall, 30 caries-free human third molars were sectioned into dentin specimens (n=120) and randomly assigned to control or treatment groups (Curodont™ D'Senz, PRG Barrier Coat, and Curodont™ Repair). After 24 h of artificial saliva storage, dentin microhardness, surface morphology, open dentin tubule count, elemental composition, and penetration depth were evaluated using Vickers microhardness testing, SEM/EDS, and CLSM. Statistical analyses were conducted with a 0.05 significance level. Results: The microhardness measurements showed a statistically significant increase in all groups in comparison with the control group (p<0.05), with no significant differences between the treated groups (p>0.05). EDS analysis showed statistically significant differences between the groups, with the highest calcium and phosphorus levels observed in the PRG Barrier Coat group (p<0.05). SEM analysis showed that the PRG Barrier Coat treatment resulted in the most extensive tubule occlusion and the smallest open tubule diameters (p<0.05). Curodont™ D'Senz and PRG Barrier Coat showed the most significant tubule penetration depths and the highest laser fluorescence values, as per CLSM analyses (p<0.001). Conclusion: The findings suggested that the tested materials may occlude dentinal tubules and penetrate dentin to varying extents, with PRG Barrier Coat showing the most pronounced effect. Self-assembling peptide-based agents show limited short-term efficacy but offer potential for biomimetic remineralization. |
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| Substance Nomenclature: | 0 (Dentin Desensitizing Agents) 0 (Peptides) 0 (Saliva, Artificial) 0 (Caseins) |
| Entry Date(s): | Date Created: 20260722 Date Completed: 20260722 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13290203 |
| DOI: | 10.1590/1678-7765-2026-0127 |
| PMID: | 42484238 |
| Βάση Δεδομένων: | MEDLINE |
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