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Evaluation of the early effects of peptide-containing agents in sensitivity treatment regarding their structural, morphological, and elemental changes in dentin tissue and their penetration efficacy.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Evaluation of the early effects of peptide-containing agents in sensitivity treatment regarding their structural, morphological, and elemental changes in dentin tissue and their penetration efficacy.
Συγγραφείς: Ozdemir T; Izmir Katip Celebi University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey., Savas S; Izmir Katip Celebi University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey., Izgi EK; Izmir Katip Celebi University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey.
Πηγή: Journal of applied oral science : revista FOB [J Appl Oral Sci] 2026 Jul 17; Vol. 34, pp. e20260127. Date of Electronic Publication: 2026 Jul 17 (Print Publication: 2026).
Τύπος έκδοσης: Journal Article; Evaluation Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Faculdade de Odontologia de Bauru, USP Country of Publication: Brazil NLM ID: 101189774 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-7765 (Electronic) Linking ISSN: 16787757 NLM ISO Abbreviation: J Appl Oral Sci Subsets: MEDLINE
Imprint Name(s): Original Publication: Bauru, SP : Faculdade de Odontologia de Bauru, USP, [2003]-
Ιατρικοί όροι (MeSH): Dentin*/drug effects , Dentin*/chemistry , Dentin*/ultrastructure , Dentin Desensitizing Agents*/pharmacology , Dentin Desensitizing Agents*/chemistry , Dentin Sensitivity*/drug therapy , Peptides*/pharmacology , Peptides*/chemistry , Caseins*/chemistry , Caseins*/pharmacology, Surface Properties/drug effects ; Hardness/drug effects ; Dentin Permeability/drug effects ; Saliva, Artificial/chemistry ; Humans ; Time Factors ; Microscopy, Electron, Scanning ; Materials Testing ; Reproducibility of Results ; Reference Values ; Spectrometry, X-Ray Emission ; Random Allocation ; Microscopy, Confocal ; Hardness Tests ; Treatment Outcome ; Statistics, Nonparametric
Περίληψη: Correspondence: Ebru Kucukyılmaz Izgı - Izmir Katip Celebi University - Faculty of Dentistry - Department of Pediatric Dentistry - Cigli - Izmir - Turkey - E-mail: ebrukucukyilmaz@hotmail.com - Tel: +902323524040.
Purpose: This study aimed to evaluate the effects of various therapeutic agents on dentin tissue in the management of dentin hypersensitivity.
Methodology: Overall, 30 caries-free human third molars were sectioned into dentin specimens (n=120) and randomly assigned to control or treatment groups (Curodont™ D'Senz, PRG Barrier Coat, and Curodont™ Repair). After 24 h of artificial saliva storage, dentin microhardness, surface morphology, open dentin tubule count, elemental composition, and penetration depth were evaluated using Vickers microhardness testing, SEM/EDS, and CLSM. Statistical analyses were conducted with a 0.05 significance level.
Results: The microhardness measurements showed a statistically significant increase in all groups in comparison with the control group (p<0.05), with no significant differences between the treated groups (p>0.05). EDS analysis showed statistically significant differences between the groups, with the highest calcium and phosphorus levels observed in the PRG Barrier Coat group (p<0.05). SEM analysis showed that the PRG Barrier Coat treatment resulted in the most extensive tubule occlusion and the smallest open tubule diameters (p<0.05). Curodont™ D'Senz and PRG Barrier Coat showed the most significant tubule penetration depths and the highest laser fluorescence values, as per CLSM analyses (p<0.001).
Conclusion: The findings suggested that the tested materials may occlude dentinal tubules and penetrate dentin to varying extents, with PRG Barrier Coat showing the most pronounced effect. Self-assembling peptide-based agents show limited short-term efficacy but offer potential for biomimetic remineralization.
References: Dent Mater. 2022 Oct;38(10):1669-1678. (PMID: 36089408)
J Dent Res. 2019 Mar;98(3):347-354. (PMID: 30612505)
Materials (Basel). 2020 May 06;13(9):. (PMID: 32384599)
Biomimetics (Basel). 2023 Jul 04;8(3):. (PMID: 37504178)
Arch Oral Biol. 2008 Nov;53(11):1017-22. (PMID: 18672228)
ACS Biomater Sci Eng. 2023 Mar 13;9(3):1486-1495. (PMID: 36854046)
Polymers (Basel). 2022 Feb 18;14(4):. (PMID: 35215706)
J Oral Sci. 2018 Sep 23;60(3):367-373. (PMID: 29984784)
J Dent. 2025 Jul;158:105803. (PMID: 40324577)
Am J Dent. 2023 Aug;36(4):193-200. (PMID: 37587030)
Int J Dent. 2018 Apr 4;2018:5701638. (PMID: 29849637)
Lasers Med Sci. 2023 Apr 18;38(1):103. (PMID: 37069368)
Dent Mater J. 2021 Mar 31;40(2):416-421. (PMID: 33177310)
J Int Soc Prev Community Dent. 2022 Aug 29;12(4):436-441. (PMID: 36312578)
Braz Oral Res. 2025 Feb 07;39:e016. (PMID: 39936715)
Proc Finn Dent Soc. 1992;88 Suppl 1:7-13. (PMID: 1508916)
Materials (Basel). 2020 Feb 05;13(3):. (PMID: 32033430)
Am J Dent. 2013 Oct;26(5):286-90. (PMID: 24479282)
ScientificWorldJournal. 2015;2015:764905. (PMID: 25879070)
Caries Res. 2019;53(3):284-295. (PMID: 30296788)
J Clin Periodontol. 1987 May;14(5):280-4. (PMID: 3475295)
Sci Rep. 2025 Apr 03;15(1):11512. (PMID: 40181020)
J Clin Periodontol. 1983 Jul;10(4):351-63. (PMID: 6350374)
Microsc Res Tech. 2019 Jul;82(7):1065-1072. (PMID: 30884045)
Clin Oral Investig. 2021 Feb;25(2):683-690. (PMID: 32968946)
J Dent Res. 2017 Jul;96(7):790-797. (PMID: 28346861)
Clin Oral Investig. 2023 Mar;27(3):1265-1276. (PMID: 36305964)
Oper Dent. 2014 Mar-Apr;39(2):159-65. (PMID: 23802637)
Sci Rep. 2020 Mar 6;10(1):4195. (PMID: 32144336)
J Mech Behav Biomed Mater. 2018 May;81:214-221. (PMID: 29550716)
J Mater Sci Mater Med. 2012 Jun;23(6):1521-32. (PMID: 22466816)
Caries Res. 2013;47(5):399-405. (PMID: 23615395)
Substance Nomenclature: 0 (Dentin Desensitizing Agents)
0 (Peptides)
0 (Saliva, Artificial)
0 (Caseins)
Entry Date(s): Date Created: 20260722 Date Completed: 20260722 Latest Revision: 20260813
Update Code: 20260814
PubMed Central ID: PMC13290203
DOI: 10.1590/1678-7765-2026-0127
PMID: 42484238
Βάση Δεδομένων: MEDLINE
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  Data: Evaluation of the early effects of peptide-containing agents in sensitivity treatment regarding their structural, morphological, and elemental changes in dentin tissue and their penetration efficacy.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Ozdemir+T%22&quot;&gt;Ozdemir T&lt;/searchLink&gt;; Izmir Katip Celebi University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Savas+S%22&quot;&gt;Savas S&lt;/searchLink&gt;; Izmir Katip Celebi University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Izgi+EK%22&quot;&gt;Izgi EK&lt;/searchLink&gt;; Izmir Katip Celebi University, Faculty of Dentistry, Department of Pediatric Dentistry, Izmir, Turkey.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22101189774%22&quot;&gt;Journal of applied oral science : revista FOB&lt;/searchLink&gt; [J Appl Oral Sci] 2026 Jul 17; Vol. 34, pp. e20260127. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2026 Jul 17 (&lt;i&gt;Print Publication: &lt;/i&gt;2026).
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  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin%22&quot;&gt;Dentin*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin%22&quot;&gt;Dentin*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin%22&quot;&gt;Dentin*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+ultrastructure%22&quot;&gt;ultrastructure&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Desensitizing+Agents%22&quot;&gt;Dentin Desensitizing Agents*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Desensitizing+Agents+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Desensitizing+Agents%22&quot;&gt;Dentin Desensitizing Agents*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Desensitizing+Agents+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Sensitivity%22&quot;&gt;Dentin Sensitivity*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Dentin+Sensitivity+drug+therapy%22&quot;&gt;drug therapy&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Peptides%22&quot;&gt;Peptides*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Peptides+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Peptides%22&quot;&gt;Peptides*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Peptides+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Caseins%22&quot;&gt;Caseins*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Caseins+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Caseins%22&quot;&gt;Caseins*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Caseins+pharmacology%22&quot;&gt;pharmacology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Surface+Properties%22&quot;&gt;Surface Properties&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Surface+Properties+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Hardness%22&quot;&gt;Hardness&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Hardness+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dentin+Permeability%22&quot;&gt;Dentin Permeability&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Dentin+Permeability+drug+effects%22&quot;&gt;drug effects&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Saliva%2C+Artificial%22&quot;&gt;Saliva, Artificial&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Saliva%2C+Artificial+chemistry%22&quot;&gt;chemistry&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Time+Factors%22&quot;&gt;Time Factors&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Microscopy%2C+Electron%2C+Scanning%22&quot;&gt;Microscopy, Electron, Scanning&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Materials+Testing%22&quot;&gt;Materials Testing&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Reproducibility+of+Results%22&quot;&gt;Reproducibility of Results&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Reference+Values%22&quot;&gt;Reference Values&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Spectrometry%2C+X-Ray+Emission%22&quot;&gt;Spectrometry, X-Ray Emission&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Random+Allocation%22&quot;&gt;Random Allocation&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Microscopy%2C+Confocal%22&quot;&gt;Microscopy, Confocal&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Hardness+Tests%22&quot;&gt;Hardness Tests&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Treatment+Outcome%22&quot;&gt;Treatment Outcome&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Statistics%2C+Nonparametric%22&quot;&gt;Statistics, Nonparametric&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Correspondence: Ebru Kucukyılmaz Izgı - Izmir Katip Celebi University - Faculty of Dentistry - Department of Pediatric Dentistry - Cigli - Izmir - Turkey - E-mail: ebrukucukyilmaz@hotmail.com - Tel: +902323524040.&lt;br /&gt;Purpose: This study aimed to evaluate the effects of various therapeutic agents on dentin tissue in the management of dentin hypersensitivity.&lt;br /&gt;Methodology: Overall, 30 caries-free human third molars were sectioned into dentin specimens (n=120) and randomly assigned to control or treatment groups (Curodont™ D&#39;Senz, PRG Barrier Coat, and Curodont™ Repair). After 24 h of artificial saliva storage, dentin microhardness, surface morphology, open dentin tubule count, elemental composition, and penetration depth were evaluated using Vickers microhardness testing, SEM/EDS, and CLSM. Statistical analyses were conducted with a 0.05 significance level.&lt;br /&gt;Results: The microhardness measurements showed a statistically significant increase in all groups in comparison with the control group (p&amp;lt;0.05), with no significant differences between the treated groups (p&amp;gt;0.05). EDS analysis showed statistically significant differences between the groups, with the highest calcium and phosphorus levels observed in the PRG Barrier Coat group (p&amp;lt;0.05). SEM analysis showed that the PRG Barrier Coat treatment resulted in the most extensive tubule occlusion and the smallest open tubule diameters (p&amp;lt;0.05). Curodont™ D&#39;Senz and PRG Barrier Coat showed the most significant tubule penetration depths and the highest laser fluorescence values, as per CLSM analyses (p&amp;lt;0.001).&lt;br /&gt;Conclusion: The findings suggested that the tested materials may occlude dentinal tubules and penetrate dentin to varying extents, with PRG Barrier Coat showing the most pronounced effect. Self-assembling peptide-based agents show limited short-term efficacy but offer potential for biomimetic remineralization.
– Name: Ref
  Label: References
  Group: RefInfo
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(PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2229550716%22&quot;&gt;29550716)&lt;/searchLink&gt;&lt;br /&gt;J Mater Sci Mater Med. 2012 Jun;23(6):1521-32. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2222466816%22&quot;&gt;22466816)&lt;/searchLink&gt;&lt;br /&gt;Caries Res. 2013;47(5):399-405. (PMID: &lt;searchLink fieldCode=&quot;PM&quot; term=&quot;%2223615395%22&quot;&gt;23615395)&lt;/searchLink&gt;
– Name: NumberCAS
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  Label: PubMed Central ID
  Group: ID
  Data: PMC13290203
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1590/1678-7765-2026-0127
– Name: AN
  Label: PMID
  Group: ID
  Data: 42484238
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42484238
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1590/1678-7765-2026-0127
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: e20260127
    Subjects:
      – SubjectFull: Surface Properties drug effects
        Type: general
      – SubjectFull: Hardness drug effects
        Type: general
      – SubjectFull: Dentin Permeability drug effects
        Type: general
      – SubjectFull: Saliva, Artificial chemistry
        Type: general
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Time Factors
        Type: general
      – SubjectFull: Microscopy, Electron, Scanning
        Type: general
      – SubjectFull: Materials Testing
        Type: general
      – SubjectFull: Reproducibility of Results
        Type: general
      – SubjectFull: Reference Values
        Type: general
      – SubjectFull: Spectrometry, X-Ray Emission
        Type: general
      – SubjectFull: Random Allocation
        Type: general
      – SubjectFull: Microscopy, Confocal
        Type: general
      – SubjectFull: Hardness Tests
        Type: general
      – SubjectFull: Treatment Outcome
        Type: general
      – SubjectFull: Statistics, Nonparametric
        Type: general
      – SubjectFull: Dentin drug effects
        Type: general
      – SubjectFull: Dentin chemistry
        Type: general
      – SubjectFull: Dentin ultrastructure
        Type: general
      – SubjectFull: Dentin Desensitizing Agents pharmacology
        Type: general
      – SubjectFull: Dentin Desensitizing Agents chemistry
        Type: general
      – SubjectFull: Dentin Sensitivity drug therapy
        Type: general
      – SubjectFull: Peptides pharmacology
        Type: general
      – SubjectFull: Peptides chemistry
        Type: general
      – SubjectFull: Caseins chemistry
        Type: general
      – SubjectFull: Caseins pharmacology
        Type: general
    Titles:
      – TitleFull: Evaluation of the early effects of peptide-containing agents in sensitivity treatment regarding their structural, morphological, and elemental changes in dentin tissue and their penetration efficacy.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ozdemir T
      – PersonEntity:
          Name:
            NameFull: Savas S
      – PersonEntity:
          Name:
            NameFull: Izgi EK
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 17
              M: 07
              Text: 2026 Jul 17
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1678-7765
          Numbering:
            – Type: volume
              Value: 34
          Titles:
            – TitleFull: Journal of applied oral science : revista FOB
              Type: main
ResultId 1