Academic Journal
Development of an adjustable dynamic phantom for testing deviceless motion correction algorithm in PET.
| Τίτλος: | Development of an adjustable dynamic phantom for testing deviceless motion correction algorithm in PET. |
|---|---|
| Συγγραφείς: | Kühnel C; Clinic for Nuclear Medicine, University Hospital Jena, Jena, Thuringia, Germany., Schmidt TN; Clinic for Nuclear Medicine, University Hospital Jena, Jena, Thuringia, Germany., Schreiber L; Clinic for Nuclear Medicine, University Hospital Jena, Jena, Thuringia, Germany., Ginter H; Central Research Facilities, University Hospital Jena, Jena, Thuringia, Deutschland., Händel M; Central Research Facilities, University Hospital Jena, Jena, Thuringia, Deutschland., Freesmeyer M; Clinic for Nuclear Medicine, University Hospital Jena, Jena, Thuringia, Germany., Gühne F; Clinic for Nuclear Medicine, University Hospital Jena, Jena, Thuringia, Germany. |
| Πηγή: | Medical physics [Med Phys] 2026 Aug; Vol. 53 (8), pp. e70577. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 0425746 Publication Model: Print Cited Medium: Internet ISSN: 2473-4209 (Electronic) Linking ISSN: 00942405 NLM ISO Abbreviation: Med Phys Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2017- : Hoboken, NJ : John Wiley and Sons, Inc. Original Publication: Lancaster, Pa., Published for the American Assn. of Physicists in Medicine by the American Institute of Physics. |
| Ιατρικοί όροι (MeSH): | Image Processing, Computer-Assisted*/methods , Image Processing, Computer-Assisted*/instrumentation , Positron-Emission Tomography*/instrumentation , Phantoms, Imaging* , Algorithms*, Movement ; Polymethyl Methacrylate |
| Περίληψη: | Background: Respiratory motion during PET Imaging leads to blurring, volumetric overestimation, and reduced quantitative accuracy. Deviceless motion correction algorithms (MCA) such as OncoFreeze (OF) by Siemens Healthineers (Forchheim, Germany) extract respiratory waveforms from list-mode data but require validation that cannot be obtained in vivo. Purpose: To develop and validate an adjustable dynamic phantom with fillable spheres for quantitative assessment of deviceless PET motion correction. Methods: A microprocessor-controlled two-axis phantom was constructed to generate linear craniocaudal (cc), ventrodorsal (vd), and diagonal (diag) motion with amplitudes of 0-40 mm and frequencies of 10-40 min- 1. Polymethylmethacrylate (PMMA) spheres (4, 1, and 0.25 mL) filled with 1 8F-fluorodeoxyglucose (FDG) were placed in a water-filled PMMA tank and imaged on a Biograph Vision 600 PET/CT (Siemens Healthineers AG, Forchheim, Germany). For each sphere and direction, 2-min PET scans were acquired with and without MCA, yielding 288 datasets. Volumes, activities, and recovery coefficients (RCs) were extracted using two different isocontours. Results: Without correction, motion produced substantial overestimation of apparent volume: +15%-55% (4 mL), +81%-166% (1 mL) and +276%-509% (0.25 mL), depending on trajectory and IC Conclusions: The phantom provides a reproducible ground-truth framework for evaluating deviceless PET motion correction. MCA reduces motion-induced blurring and volumetric inflation, though correction remains size- and direction-dependent. The system enables systematic benchmarking and further optimization of motion-correction algorithms. (© 2026 The Author(s). Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.) |
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| Substance Nomenclature: | 9011-14-7 (Polymethyl Methacrylate) |
| Entry Date(s): | Date Created: 20260722 Date Completed: 20260722 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13389335 |
| DOI: | 10.1002/mp.70577 |
| PMID: | 42482411 |
| Βάση Δεδομένων: | MEDLINE |
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