Academic Journal
Development of a GPU-based dose calculation engine for MRI-guided proton therapy.
| Τίτλος: | Development of a GPU-based dose calculation engine for MRI-guided proton therapy. |
|---|---|
| Συγγραφείς: | Gu Y; Department of Engineering and Applied Physics, University of Science and Technology of China, Hefei, Anhui, China., Wang Y; Department of Engineering and Applied Physics, University of Science and Technology of China, Hefei, Anhui, China.; Hefei Ion Medical Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China., Liu M; Department of Engineering and Applied Physics, University of Science and Technology of China, Hefei, Anhui, China., Gong H; Department of Engineering and Applied Physics, University of Science and Technology of China, Hefei, Anhui, China., Yuan X; Department of Engineering and Applied Physics, University of Science and Technology of China, Hefei, Anhui, China., Lu HM; Hefei Ion Medical Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.; Ion Medical Research Institute, University of Science and Technology of China, Hefei, Anhui, China., Yang Y; Department of Engineering and Applied Physics, University of Science and Technology of China, Hefei, Anhui, China.; Ion Medical Research Institute, University of Science and Technology of China, Hefei, Anhui, China.; Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. |
| Πηγή: | Medical physics [Med Phys] 2026 Aug; Vol. 53 (8), pp. e70571. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: John Wiley and Sons, Inc Country of Publication: United States NLM ID: 0425746 Publication Model: Print Cited Medium: Internet ISSN: 2473-4209 (Electronic) Linking ISSN: 00942405 NLM ISO Abbreviation: Med Phys Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2017- : Hoboken, NJ : John Wiley and Sons, Inc. Original Publication: Lancaster, Pa., Published for the American Assn. of Physicists in Medicine by the American Institute of Physics. |
| Ιατρικοί όροι (MeSH): | Proton Therapy*/methods , Radiotherapy, Image-Guided*/instrumentation , Radiotherapy, Image-Guided*/methods , Radiotherapy Planning, Computer-Assisted*/methods , Magnetic Resonance Imaging* , Computer Graphics* , Radiation Dosage*, Humans ; Radiotherapy Dosage ; Monte Carlo Method ; Phantoms, Imaging ; Magnetic Fields |
| Περίληψη: | Background: Magnetic resonance imaging (MRI)-guided proton therapy (MRPT) integrates the superior soft-tissue contrast of MRI with the high dose conformity of proton therapy. Clinical implementation of MRPT requires an efficient and accurate dose calculation engine capable of accounting for the heterogeneous magnetic field effects on proton beams. Purpose: This study developed a GPU-based proton and ion dose engine (gPRIDE) for fast and accurate dose calculations in MRPT under realistic clinical configurations. Methods: To account for magnetic focusing effects, a novel beam profile correction method was developed. Computational efficiency was enhanced through a region-of-interest-based dose calculation, a linear approximation in ray tracing, and hybrid pencil-beam- and voxel-level GPU parallelization. Three-dimensional magnetic field maps with varying magnetic field strengths were used for validation. gPRIDE was validated against Monte Carlo simulations in a water phantom and four patient cases (prostate, liver, lung, and brain) under two beam orientations: beams parallel and perpendicular to the main magnetic field. Results: gPRIDE achieved gamma passing rates exceeding 99% under the 2 %/2 mm criterion for all cases except the lung case, where pronounced anatomical heterogeneity posed challenges to analytical modeling. Despite this, gPRIDE still achieved a gamma passing rate INLINEMATH 95% under the 3 %/3 mm criterion. Wall-clock time per treatment plan ranged from 2.7 s to 13.7 s on an NVIDIA GeForce RTX 3060 GPU. Conclusions: gPRIDE enables fast and accurate dose computations under realistic three-dimensional magnetic field maps and supports both beam orientations relative to the main magnetic field. The combination of computational efficiency, accuracy, and versatility facilitates its integration into clinical MRPT workflows. (© 2026 American Association of Physicists in Medicine.) |
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| Grant Information: | 2023YFC3504200 National Key Research and Development Program of China; KY2030000197 Fundamental Research Funds for the Central Universities; Hefei Comprehensive National Science Center |
| Contributed Indexing: | Keywords: MRI guidance; dose calculation; proton therapy |
| Entry Date(s): | Date Created: 20260722 Date Completed: 20260722 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13389122 |
| DOI: | 10.1002/mp.70571 |
| PMID: | 42482386 |
| Βάση Δεδομένων: | MEDLINE |
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