Academic Journal
Association of monoamine system parameters with violent criminal behavior.
| Τίτλος: | Association of monoamine system parameters with violent criminal behavior. |
|---|---|
| Συγγραφείς: | Peregud D; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution 'V. Serbsky National Medical Research Centre for Psychiatry and Narcology' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Laboratory of Functional Biochemistry of Nervous System, Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, Russia., Gadisov T; Department of Emergency Psychiatry and Disaster Response, Federal State Budgetary Institution 'V. Serbsky National Medical Research Centre for Psychiatry and Narcology' of the Ministry of Health of the Russian Federation, Moscow, Russia., Pavlova O; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution 'V. Serbsky National Medical Research Centre for Psychiatry and Narcology' of the Ministry of Health of the Russian Federation, Moscow, Russia., Nebogina K; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution 'V. Serbsky National Medical Research Centre for Psychiatry and Narcology' of the Ministry of Health of the Russian Federation, Moscow, Russia., Pavlov K; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution 'V. Serbsky National Medical Research Centre for Psychiatry and Narcology' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Schizophrenia and Psychotic Disorders, Mental-Health Clinic No. 1 Named after N.A. Alekseev, Moscow, Russia. |
| Πηγή: | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2026 Oct; Vol. 27 (8), pp. 640-654. Date of Electronic Publication: 2026 Jul 20. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101120023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1814-1412 (Electronic) Linking ISSN: 15622975 NLM ISO Abbreviation: World J Biol Psychiatry Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare Original Publication: Glasgow : WFSBP, 2000- |
| Ιατρικοί όροι (MeSH): | Hydroxyindoleacetic Acid*/urine , Homovanillic Acid*/urine , Aggression*/physiology , Aggression*/psychology , Violence*/psychology , Receptor, Serotonin, 5-HT2A*/genetics , Temperament*/physiology , Criminals*/psychology , Criminal Behavior*, Humans ; Male ; Adult ; Middle Aged ; Surveys and Questionnaires ; Receptors, Dopamine D4 |
| Περίληψη: | Objectives: The aim of this study was to assess the associations of psychometric, biochemical, and genetic parameters of the serotonin and dopamine systems with violent criminal behavior. Methods: Male participants who had no criminal records (n=110) and those who had committed interpersonal violent crimes (n=143) were included in the study. Aggression levels were estimated by means of the Buss-Perry questionnaire (BPAQ-24). The Structure of Temperament Questionnaire-Compact (STQ-77), potentially linked to monoamine neurotransmitter activity, was administered to profile temperament traits. Concentrations of monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were estimated in urine samples. The HTR2A rs6313 and DRD4 rs1800955 polymorphisms were genotyped by real-time PCR. Results: Offenders demonstrated higher levels of aggression, and decreased concentrations of 5-HIAA and HVA as compared with controls. According to the final model of multivariate binary logistic regression, total BPAQ scores (B = 0.047; p < 0.001), HVA concentrations (B = -0.004; p < 0.001), and the STQ-77 Empathy (EMP) scale (B = 0.225; p = 0.004) were the independent markers discriminating violent criminal behavior with an overall classification accuracy of 86.1%. Conclusion: Thus, the complex interplay between heightened aggression, reduced HVA levels, and specific temperament traits constitutes a neurobehavioral signature of violent criminal behavior. |
| Contributed Indexing: | Keywords: Serotonin; aggression; dopamine; functional ensemble of temperament model; violent crime |
| Substance Nomenclature: | 54-16-0 (Hydroxyindoleacetic Acid) X77S6GMS36 (Homovanillic Acid) 0 (Receptor, Serotonin, 5-HT2A) 0 (DRD4 protein, human) 0 (HTR2A protein, human) 137750-34-6 (Receptors, Dopamine D4) |
| Entry Date(s): | Date Created: 20260721 Date Completed: 20260927 Latest Revision: 20260927 |
| Update Code: | 20260928 |
| DOI: | 10.1080/15622975.2026.2704106 |
| PMID: | 42477902 |
| Βάση Δεδομένων: | MEDLINE |
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