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Association of monoamine system parameters with violent criminal behavior.

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Title: Association of monoamine system parameters with violent criminal behavior.
Authors: Peregud D; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution 'V. Serbsky National Medical Research Centre for Psychiatry and Narcology' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Laboratory of Functional Biochemistry of Nervous System, Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, Russia., Gadisov T; Department of Emergency Psychiatry and Disaster Response, Federal State Budgetary Institution 'V. Serbsky National Medical Research Centre for Psychiatry and Narcology' of the Ministry of Health of the Russian Federation, Moscow, Russia., Pavlova O; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution 'V. Serbsky National Medical Research Centre for Psychiatry and Narcology' of the Ministry of Health of the Russian Federation, Moscow, Russia., Nebogina K; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution 'V. Serbsky National Medical Research Centre for Psychiatry and Narcology' of the Ministry of Health of the Russian Federation, Moscow, Russia., Pavlov K; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution 'V. Serbsky National Medical Research Centre for Psychiatry and Narcology' of the Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Schizophrenia and Psychotic Disorders, Mental-Health Clinic No. 1 Named after N.A. Alekseev, Moscow, Russia.
Source: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2026 Oct; Vol. 27 (8), pp. 640-654. Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101120023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1814-1412 (Electronic) Linking ISSN: 15622975 NLM ISO Abbreviation: World J Biol Psychiatry Subsets: MEDLINE
Imprint Name(s): Publication: London : Informa Healthcare
Original Publication: Glasgow : WFSBP, 2000-
MeSH Terms: Hydroxyindoleacetic Acid*/urine , Homovanillic Acid*/urine , Aggression*/physiology , Aggression*/psychology , Violence*/psychology , Receptor, Serotonin, 5-HT2A*/genetics , Temperament*/physiology , Criminals*/psychology , Criminal Behavior*, Humans ; Male ; Adult ; Middle Aged ; Surveys and Questionnaires ; Receptors, Dopamine D4
Abstract: Objectives: The aim of this study was to assess the associations of psychometric, biochemical, and genetic parameters of the serotonin and dopamine systems with violent criminal behavior.
Methods: Male participants who had no criminal records (n=110) and those who had committed interpersonal violent crimes (n=143) were included in the study. Aggression levels were estimated by means of the Buss-Perry questionnaire (BPAQ-24). The Structure of Temperament Questionnaire-Compact (STQ-77), potentially linked to monoamine neurotransmitter activity, was administered to profile temperament traits. Concentrations of monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were estimated in urine samples. The HTR2A rs6313 and DRD4 rs1800955 polymorphisms were genotyped by real-time PCR.
Results: Offenders demonstrated higher levels of aggression, and decreased concentrations of 5-HIAA and HVA as compared with controls. According to the final model of multivariate binary logistic regression, total BPAQ scores (B = 0.047; p < 0.001), HVA concentrations (B = -0.004; p < 0.001), and the STQ-77 Empathy (EMP) scale (B = 0.225; p = 0.004) were the independent markers discriminating violent criminal behavior with an overall classification accuracy of 86.1%.
Conclusion: Thus, the complex interplay between heightened aggression, reduced HVA levels, and specific temperament traits constitutes a neurobehavioral signature of violent criminal behavior.
Contributed Indexing: Keywords: Serotonin; aggression; dopamine; functional ensemble of temperament model; violent crime
Substance Nomenclature: 54-16-0 (Hydroxyindoleacetic Acid)
X77S6GMS36 (Homovanillic Acid)
0 (Receptor, Serotonin, 5-HT2A)
0 (DRD4 protein, human)
0 (HTR2A protein, human)
137750-34-6 (Receptors, Dopamine D4)
Entry Date(s): Date Created: 20260721 Date Completed: 20260927 Latest Revision: 20260927
Update Code: 20260928
DOI: 10.1080/15622975.2026.2704106
PMID: 42477902
Database: MEDLINE
FullText Text:
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PubType: Academic Journal
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  Data: Association of monoamine system parameters with violent criminal behavior.
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  Data: &lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Peregud+D%22&quot;&gt;Peregud D&lt;/searchLink&gt;; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution &#39;V. Serbsky National Medical Research Centre for Psychiatry and Narcology&#39; of the Ministry of Health of the Russian Federation, Moscow, Russia.; Laboratory of Functional Biochemistry of Nervous System, Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Gadisov+T%22&quot;&gt;Gadisov T&lt;/searchLink&gt;; Department of Emergency Psychiatry and Disaster Response, Federal State Budgetary Institution &#39;V. Serbsky National Medical Research Centre for Psychiatry and Narcology&#39; of the Ministry of Health of the Russian Federation, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Pavlova+O%22&quot;&gt;Pavlova O&lt;/searchLink&gt;; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution &#39;V. Serbsky National Medical Research Centre for Psychiatry and Narcology&#39; of the Ministry of Health of the Russian Federation, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Nebogina+K%22&quot;&gt;Nebogina K&lt;/searchLink&gt;; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution &#39;V. Serbsky National Medical Research Centre for Psychiatry and Narcology&#39; of the Ministry of Health of the Russian Federation, Moscow, Russia.&lt;br /&gt;&lt;searchLink fieldCode=&quot;AU&quot; term=&quot;%22Pavlov+K%22&quot;&gt;Pavlov K&lt;/searchLink&gt;; Department of Fundamental and Applied Neurobiology, Federal State Budgetary Institution &#39;V. Serbsky National Medical Research Centre for Psychiatry and Narcology&#39; of the Ministry of Health of the Russian Federation, Moscow, Russia.; Department of Schizophrenia and Psychotic Disorders, Mental-Health Clinic No. 1 Named after N.A. Alekseev, Moscow, Russia.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22101120023%22&quot;&gt;The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry&lt;/searchLink&gt; [World J Biol Psychiatry] 2026 Oct; Vol. 27 (8), pp. 640-654. &lt;i&gt;Date of Electronic Publication: &lt;/i&gt;2026 Jul 20.
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  Data: &lt;i&gt;Publisher: &lt;/i&gt;&lt;searchLink fieldCode=&quot;PB&quot; term=&quot;%22Informa+Healthcare%22&quot;&gt;Informa Healthcare &lt;/searchLink&gt;&lt;i&gt;Country of Publication: &lt;/i&gt;England &lt;i&gt;NLM ID: &lt;/i&gt;101120023 &lt;i&gt;Publication Model: &lt;/i&gt;Print-Electronic &lt;i&gt;Cited Medium: &lt;/i&gt;Internet &lt;i&gt;ISSN: &lt;/i&gt;1814-1412 (Electronic) &lt;i&gt;Linking ISSN: &lt;/i&gt;&lt;searchLink fieldCode=&quot;IS&quot; term=&quot;%2215622975%22&quot;&gt;15622975 &lt;/searchLink&gt;&lt;i&gt;NLM ISO Abbreviation: &lt;/i&gt;World J Biol Psychiatry &lt;i&gt;Subsets: &lt;/i&gt;MEDLINE
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  Data: &lt;i&gt;Publication&lt;/i&gt;: London : Informa Healthcare&lt;br /&gt;&lt;i&gt;Original Publication&lt;/i&gt;: Glasgow : WFSBP, 2000-
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  Data: &lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Hydroxyindoleacetic+Acid%22&quot;&gt;Hydroxyindoleacetic Acid*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Hydroxyindoleacetic+Acid+urine%22&quot;&gt;urine&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Homovanillic+Acid%22&quot;&gt;Homovanillic Acid*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Homovanillic+Acid+urine%22&quot;&gt;urine&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Aggression%22&quot;&gt;Aggression*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Aggression+physiology%22&quot;&gt;physiology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Aggression%22&quot;&gt;Aggression*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Aggression+psychology%22&quot;&gt;psychology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Violence%22&quot;&gt;Violence*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Violence+psychology%22&quot;&gt;psychology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Receptor%2C+Serotonin%2C+5-HT2A%22&quot;&gt;Receptor, Serotonin, 5-HT2A*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Receptor%2C+Serotonin%2C+5-HT2A+genetics%22&quot;&gt;genetics&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Temperament%22&quot;&gt;Temperament*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Temperament+physiology%22&quot;&gt;physiology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Criminals%22&quot;&gt;Criminals*&lt;/searchLink&gt;/&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Criminals+psychology%22&quot;&gt;psychology&lt;/searchLink&gt; &lt;br /&gt;&lt;searchLink fieldCode=&quot;MM&quot; term=&quot;%22Criminal+Behavior%22&quot;&gt;Criminal Behavior*&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Humans%22&quot;&gt;Humans&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Male%22&quot;&gt;Male&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Adult%22&quot;&gt;Adult&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Middle+Aged%22&quot;&gt;Middle Aged&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Surveys+and+Questionnaires%22&quot;&gt;Surveys and Questionnaires&lt;/searchLink&gt; ; &lt;searchLink fieldCode=&quot;MH&quot; term=&quot;%22Receptors%2C+Dopamine+D4%22&quot;&gt;Receptors, Dopamine D4&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: The aim of this study was to assess the associations of psychometric, biochemical, and genetic parameters of the serotonin and dopamine systems with violent criminal behavior.&lt;br /&gt;Methods: Male participants who had no criminal records (n=110) and those who had committed interpersonal violent crimes (n=143) were included in the study. Aggression levels were estimated by means of the Buss-Perry questionnaire (BPAQ-24). The Structure of Temperament Questionnaire-Compact (STQ-77), potentially linked to monoamine neurotransmitter activity, was administered to profile temperament traits. Concentrations of monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were estimated in urine samples. The HTR2A rs6313 and DRD4 rs1800955 polymorphisms were genotyped by real-time PCR.&lt;br /&gt;Results: Offenders demonstrated higher levels of aggression, and decreased concentrations of 5-HIAA and HVA as compared with controls. According to the final model of multivariate binary logistic regression, total BPAQ scores (B = 0.047; p &amp;lt; 0.001), HVA concentrations (B = -0.004; p &amp;lt; 0.001), and the STQ-77 Empathy (EMP) scale (B = 0.225; p = 0.004) were the independent markers discriminating violent criminal behavior with an overall classification accuracy of 86.1%.&lt;br /&gt;Conclusion: Thus, the complex interplay between heightened aggression, reduced HVA levels, and specific temperament traits constitutes a neurobehavioral signature of violent criminal behavior.
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: &lt;i&gt;Keywords: &lt;/i&gt;Serotonin; aggression; dopamine; functional ensemble of temperament model; violent crime
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 54-16-0 (Hydroxyindoleacetic Acid)&lt;br /&gt;X77S6GMS36 (Homovanillic Acid)&lt;br /&gt;0 (Receptor, Serotonin, 5-HT2A)&lt;br /&gt;0 (DRD4 protein, human)&lt;br /&gt;0 (HTR2A protein, human)&lt;br /&gt;137750-34-6 (Receptors, Dopamine D4)
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  Data: &lt;i&gt;Date Created: &lt;/i&gt;20260721 &lt;i&gt;Date Completed: &lt;/i&gt;20260927 &lt;i&gt;Latest Revision: &lt;/i&gt;20260927
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  Data: 20260928
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  Data: 10.1080/15622975.2026.2704106
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  Data: 42477902
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42477902
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        Value: 10.1080/15622975.2026.2704106
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        Text: English
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        StartPage: 640
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      – SubjectFull: Humans
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      – SubjectFull: Male
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      – SubjectFull: Adult
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      – SubjectFull: Aggression physiology
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      – TitleFull: Association of monoamine system parameters with violent criminal behavior.
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              Text: 2026 Oct
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