Academic Journal
Clinical outcomes of percutaneous versus peroral intraoperative neuromonitoring strategies in transoral endoscopic thyroidectomy vestibular approach: A retrospective analysis of 2,201 patients.
| Τίτλος: | Clinical outcomes of percutaneous versus peroral intraoperative neuromonitoring strategies in transoral endoscopic thyroidectomy vestibular approach: A retrospective analysis of 2,201 patients. |
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| Συγγραφείς: | Uen YH; Department of Surgery, Asia University Hospital, Taichung, Taiwan; Department of Surgery, Tainan Municipal An-Nan Hospital, Tainan, Taiwan; Uen YH Surgical Clinic, Tainan, Taiwan., Wu CW; Department of Otorhinolaryngology- Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan., Wen KS; Department of Pharmacy, Chi Mei Medical Center, Tainan, Taiwan., Lin YF; Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan., Lin KY; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan. Electronic address: d84306@yahoo.com.tw. |
| Πηγή: | Surgery [Surgery] 2026 Oct; Vol. 198, pp. 110432. Date of Electronic Publication: 2026 Jul 01. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Mosby Country of Publication: United States NLM ID: 0417347 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-7361 (Electronic) Linking ISSN: 00396060 NLM ISO Abbreviation: Surgery Subsets: MEDLINE |
| Imprint Name(s): | Publication: St. Louis, MO : Mosby Original Publication: St. Louis. |
| Ιατρικοί όροι (MeSH): | Thyroidectomy*/methods , Thyroidectomy*/adverse effects , Vocal Cord Paralysis*/prevention & control , Vocal Cord Paralysis*/etiology , Vocal Cord Paralysis*/epidemiology , Recurrent Laryngeal Nerve Injuries*/prevention & control , Recurrent Laryngeal Nerve Injuries*/etiology , Recurrent Laryngeal Nerve Injuries*/epidemiology , Recurrent Laryngeal Nerve Injuries*/diagnosis , Natural Orifice Endoscopic Surgery*/adverse effects , Natural Orifice Endoscopic Surgery*/methods , Intraoperative Neurophysiological Monitoring*/methods , Postoperative Complications*/prevention & control , Postoperative Complications*/etiology , Postoperative Complications*/epidemiology, Humans ; Female ; Retrospective Studies ; Male ; Middle Aged ; Adult ; Treatment Outcome ; Risk Factors ; Aged |
| Περίληψη: | Background: Recurrent laryngeal nerve palsy remains a critical complication in transoral endoscopic thyroidectomy vestibular approach. While intraoperative neuromonitoring is employed, the optimal strategy for reducing vocal cord palsy remains a topic of debate. Methods: This large-scale, retrospective cohort study, based on a prospectively collected database, enrolled 2,201 patients who underwent transoral endoscopic thyroidectomy vestibular approach. We compared outcomes among 3 distinct groups: nonintraoperative neuromonitoring (n = 109), peroral intraoperative neuromonitoring (n = 582, year 2016-2019), and percutaneous intraoperative neuromonitoring (n = 1,510, year 2020-May 2025). The peroral and percutaneous groups were further analyzed according to the technique used: intermittent (intermittent intraoperative neuromonitoring) or combined (intermittent intraoperative neuromonitoring + continuous intraoperative neuromonitoring). End points were the incidence of vocal cord palsy and a multivariate analysis of independent risk factors for vocal cord palsy. Results: The 2,092 intraoperative neuromonitoring patients (peroral and percutaneous) were analyzed in 4 subgroups: peroral intermittent intraoperative neuromonitoring (n = 481), peroral combined (intermittent intraoperative neuromonitoring + continuous intraoperative neuromonitoring, n = 101), percutaneous intermittent intraoperative neuromonitoring (n = 1,100), and percutaneous combined (intermittent intraoperative neuromonitoring + continuous intraoperative neuromonitoring, n = 410). Among these, the percutaneous combination (percutaneous-combined) group had a significantly lower temporary vocal cord palsy rate (0.2%) than all other groups (P < .05). This was attributed to higher technical success: percutaneous-combined intraoperative neuromonitoring achieved higher rates of persistent vagus nerve stimulation (99.7% vs 94.4%), a higher detection rate of imminent recurrent laryngeal nerve injury (4.4% vs 0.7%, P < .05), and a higher intraoperative signal recovery rate (88.9% vs 33.3%). Permanent vocal cord palsy was rare (n = 2), occurring only in the peroral groups. Critically, multivariate analysis confirmed that percutaneous combination intraoperative neuromonitoring was an independent protective factor against vocal cord palsy (odds ratio, 0.08; P = .02), whereas thyroid malignancy (odds ratio, 2.02; P = .02) and Graves disease/thyroiditis (odds ratio, 2.19; P = .03) were 2 independent risk factors. Conclusion: This large-scale study confirms that the percutaneous application of combined intermittent intraoperative neuromonitoring and continuous intraoperative neuromonitoring is a safe, feasible, and effective strategy for protecting the recurrent laryngeal nerve in the transoral endoscopic thyroidectomy vestibular approach. It is associated with reduced vocal cord palsy rates and can be considered a viable option, especially for individuals with high-risk thyroid diseases. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Conflict of Interest/Disclosure The authors have no related conflicts of interest to declare. |
| Entry Date(s): | Date Created: 20260720 Date Completed: 20260915 Latest Revision: 20260915 |
| Update Code: | 20260916 |
| DOI: | 10.1016/j.surg.2026.110432 |
| PMID: | 42475946 |
| Βάση Δεδομένων: | MEDLINE |
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| Items | – Name: Title Label: Title Group: Ti Data: Clinical outcomes of percutaneous versus peroral intraoperative neuromonitoring strategies in transoral endoscopic thyroidectomy vestibular approach: A retrospective analysis of 2,201 patients. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Uen+YH%22">Uen YH</searchLink>; Department of Surgery, Asia University Hospital, Taichung, Taiwan; Department of Surgery, Tainan Municipal An-Nan Hospital, Tainan, Taiwan; Uen YH Surgical Clinic, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+CW%22">Wu CW</searchLink>; Department of Otorhinolaryngology- Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wen+KS%22">Wen KS</searchLink>; Department of Pharmacy, Chi Mei Medical Center, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YF%22">Lin YF</searchLink>; Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+KY%22">Lin KY</searchLink>; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan. Electronic address: d84306@yahoo.com.tw. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220417347%22">Surgery</searchLink> [Surgery] 2026 Oct; Vol. 198, pp. 110432. <i>Date of Electronic Publication: </i>2026 Jul 01. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Comparative Study – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mosby%22">Mosby </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0417347 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-7361 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200396060%22">00396060 </searchLink><i>NLM ISO Abbreviation: </i>Surgery <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Publication</i>: St. Louis, MO : Mosby<br /><i>Original Publication</i>: St. Louis. – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Thyroidectomy%22">Thyroidectomy*</searchLink>/<searchLink fieldCode="MM" term="%22Thyroidectomy+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Thyroidectomy%22">Thyroidectomy*</searchLink>/<searchLink fieldCode="MM" term="%22Thyroidectomy+adverse+effects%22">adverse effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Vocal+Cord+Paralysis%22">Vocal Cord Paralysis*</searchLink>/<searchLink fieldCode="MM" term="%22Vocal+Cord+Paralysis+prevention+%26+control%22">prevention & control</searchLink> <br /><searchLink fieldCode="MM" term="%22Vocal+Cord+Paralysis%22">Vocal Cord Paralysis*</searchLink>/<searchLink fieldCode="MM" term="%22Vocal+Cord+Paralysis+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Vocal+Cord+Paralysis%22">Vocal Cord Paralysis*</searchLink>/<searchLink fieldCode="MM" term="%22Vocal+Cord+Paralysis+epidemiology%22">epidemiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Recurrent+Laryngeal+Nerve+Injuries%22">Recurrent Laryngeal Nerve Injuries*</searchLink>/<searchLink fieldCode="MM" term="%22Recurrent+Laryngeal+Nerve+Injuries+prevention+%26+control%22">prevention & control</searchLink> <br /><searchLink fieldCode="MM" term="%22Recurrent+Laryngeal+Nerve+Injuries%22">Recurrent Laryngeal Nerve Injuries*</searchLink>/<searchLink fieldCode="MM" term="%22Recurrent+Laryngeal+Nerve+Injuries+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Recurrent+Laryngeal+Nerve+Injuries%22">Recurrent Laryngeal Nerve Injuries*</searchLink>/<searchLink fieldCode="MM" term="%22Recurrent+Laryngeal+Nerve+Injuries+epidemiology%22">epidemiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Recurrent+Laryngeal+Nerve+Injuries%22">Recurrent Laryngeal Nerve Injuries*</searchLink>/<searchLink fieldCode="MM" term="%22Recurrent+Laryngeal+Nerve+Injuries+diagnosis%22">diagnosis</searchLink> <br /><searchLink fieldCode="MM" term="%22Natural+Orifice+Endoscopic+Surgery%22">Natural Orifice Endoscopic Surgery*</searchLink>/<searchLink fieldCode="MM" term="%22Natural+Orifice+Endoscopic+Surgery+adverse+effects%22">adverse effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Natural+Orifice+Endoscopic+Surgery%22">Natural Orifice Endoscopic Surgery*</searchLink>/<searchLink fieldCode="MM" term="%22Natural+Orifice+Endoscopic+Surgery+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Intraoperative+Neurophysiological+Monitoring%22">Intraoperative Neurophysiological Monitoring*</searchLink>/<searchLink fieldCode="MM" term="%22Intraoperative+Neurophysiological+Monitoring+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Postoperative+Complications%22">Postoperative Complications*</searchLink>/<searchLink fieldCode="MM" term="%22Postoperative+Complications+prevention+%26+control%22">prevention & control</searchLink> <br /><searchLink fieldCode="MM" term="%22Postoperative+Complications%22">Postoperative Complications*</searchLink>/<searchLink fieldCode="MM" term="%22Postoperative+Complications+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Postoperative+Complications%22">Postoperative Complications*</searchLink>/<searchLink fieldCode="MM" term="%22Postoperative+Complications+epidemiology%22">epidemiology</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Retrospective+Studies%22">Retrospective Studies</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Middle+Aged%22">Middle Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Treatment+Outcome%22">Treatment Outcome</searchLink> ; <searchLink fieldCode="MH" term="%22Risk+Factors%22">Risk Factors</searchLink> ; <searchLink fieldCode="MH" term="%22Aged%22">Aged</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Recurrent laryngeal nerve palsy remains a critical complication in transoral endoscopic thyroidectomy vestibular approach. While intraoperative neuromonitoring is employed, the optimal strategy for reducing vocal cord palsy remains a topic of debate.<br />Methods: This large-scale, retrospective cohort study, based on a prospectively collected database, enrolled 2,201 patients who underwent transoral endoscopic thyroidectomy vestibular approach. We compared outcomes among 3 distinct groups: nonintraoperative neuromonitoring (n = 109), peroral intraoperative neuromonitoring (n = 582, year 2016-2019), and percutaneous intraoperative neuromonitoring (n = 1,510, year 2020-May 2025). The peroral and percutaneous groups were further analyzed according to the technique used: intermittent (intermittent intraoperative neuromonitoring) or combined (intermittent intraoperative neuromonitoring + continuous intraoperative neuromonitoring). End points were the incidence of vocal cord palsy and a multivariate analysis of independent risk factors for vocal cord palsy.<br />Results: The 2,092 intraoperative neuromonitoring patients (peroral and percutaneous) were analyzed in 4 subgroups: peroral intermittent intraoperative neuromonitoring (n = 481), peroral combined (intermittent intraoperative neuromonitoring + continuous intraoperative neuromonitoring, n = 101), percutaneous intermittent intraoperative neuromonitoring (n = 1,100), and percutaneous combined (intermittent intraoperative neuromonitoring + continuous intraoperative neuromonitoring, n = 410). Among these, the percutaneous combination (percutaneous-combined) group had a significantly lower temporary vocal cord palsy rate (0.2%) than all other groups (P &lt; .05). This was attributed to higher technical success: percutaneous-combined intraoperative neuromonitoring achieved higher rates of persistent vagus nerve stimulation (99.7% vs 94.4%), a higher detection rate of imminent recurrent laryngeal nerve injury (4.4% vs 0.7%, P &lt; .05), and a higher intraoperative signal recovery rate (88.9% vs 33.3%). Permanent vocal cord palsy was rare (n = 2), occurring only in the peroral groups. Critically, multivariate analysis confirmed that percutaneous combination intraoperative neuromonitoring was an independent protective factor against vocal cord palsy (odds ratio, 0.08; P = .02), whereas thyroid malignancy (odds ratio, 2.02; P = .02) and Graves disease/thyroiditis (odds ratio, 2.19; P = .03) were 2 independent risk factors.<br />Conclusion: This large-scale study confirms that the percutaneous application of combined intermittent intraoperative neuromonitoring and continuous intraoperative neuromonitoring is a safe, feasible, and effective strategy for protecting the recurrent laryngeal nerve in the transoral endoscopic thyroidectomy vestibular approach. It is associated with reduced vocal cord palsy rates and can be considered a viable option, especially for individuals with high-risk thyroid diseases.<br /> (Copyright © 2026 Elsevier Inc. All rights reserved.) – Name: Abstract Label: Competing Interests Group: Ab Data: Conflict of Interest/Disclosure The authors have no related conflicts of interest to declare. – Name: DateEntry Label: Entry Date(s) Group: Date Data: <i>Date Created: </i>20260720 <i>Date Completed: </i>20260915 <i>Latest Revision: </i>20260915 – Name: DateUpdate Label: Update Code Group: Date Data: 20260916 – Name: DOI Label: DOI Group: ID Data: 10.1016/j.surg.2026.110432 – Name: AN Label: PMID Group: ID Data: 42475946 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.surg.2026.110432 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 110432 Subjects: – SubjectFull: Humans Type: general – SubjectFull: Female Type: general – SubjectFull: Retrospective Studies Type: general – SubjectFull: Male Type: general – SubjectFull: Middle Aged Type: general – SubjectFull: Adult Type: general – SubjectFull: Treatment Outcome Type: general – SubjectFull: Risk Factors Type: general – SubjectFull: Aged Type: general – SubjectFull: Thyroidectomy methods Type: general – SubjectFull: Thyroidectomy adverse effects Type: general – SubjectFull: Vocal Cord Paralysis prevention & control Type: general – SubjectFull: Vocal Cord Paralysis etiology Type: general – SubjectFull: Vocal Cord Paralysis epidemiology Type: general – SubjectFull: Recurrent Laryngeal Nerve Injuries prevention & control Type: general – SubjectFull: Recurrent Laryngeal Nerve Injuries etiology Type: general – SubjectFull: Recurrent Laryngeal Nerve Injuries epidemiology Type: general – SubjectFull: Recurrent Laryngeal Nerve Injuries diagnosis Type: general – SubjectFull: Natural Orifice Endoscopic Surgery adverse effects Type: general – SubjectFull: Natural Orifice Endoscopic Surgery methods Type: general – SubjectFull: Intraoperative Neurophysiological Monitoring methods Type: general – SubjectFull: Postoperative Complications prevention & control Type: general – SubjectFull: Postoperative Complications etiology Type: general – SubjectFull: Postoperative Complications epidemiology Type: general Titles: – TitleFull: Clinical outcomes of percutaneous versus peroral intraoperative neuromonitoring strategies in transoral endoscopic thyroidectomy vestibular approach: A retrospective analysis of 2,201 patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Uen YH – PersonEntity: Name: NameFull: Wu CW – PersonEntity: Name: NameFull: Wen KS – PersonEntity: Name: NameFull: Lin YF – PersonEntity: Name: NameFull: Lin KY IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: 2026 Oct Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1532-7361 Numbering: – Type: volume Value: 198 Titles: – TitleFull: Surgery Type: main |
| ResultId | 1 |