Academic Journal
Autophagy potential of polyphenols in breast carcinoma: A systematic review.
| Τίτλος: | Autophagy potential of polyphenols in breast carcinoma: A systematic review. |
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| Συγγραφείς: | Golchin A; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: Asal.golchin@outlook.com., Teymori Nobari S; Department of Clinical Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: teymourinobari1994@gmail.com., Maleki M; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: masmaleki58@gmail.com., Yazdani M; Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Department of Molecular Pathology, HKC Hospital Laboratory, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: yazdanimehdi.g@gmail.com., Yousefi B; Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Shohada Clinical Research Development Unit, Shohada Hospital, Tabriz University of Medical Science, Tabriz, Iran. Electronic address: yousefib@tbzmed.ac.ir. |
| Πηγή: | Pathology, research and practice [Pathol Res Pract] 2026 Oct; Vol. 286, pp. 156595. Date of Electronic Publication: 2026 Jul 09. |
| Τύπος έκδοσης: | Journal Article; Systematic Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 7806109 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-0631 (Electronic) Linking ISSN: 03440338 NLM ISO Abbreviation: Pathol Res Pract Subsets: MEDLINE |
| Imprint Name(s): | Publication: Stuttgart : Gustav Fischer Verlag Original Publication: Stuttgart, New York, Fischer. |
| Ιατρικοί όροι (MeSH): | Polyphenols*/pharmacology , Polyphenols*/therapeutic use , Autophagy*/drug effects , Breast Neoplasms*/drug therapy , Breast Neoplasms*/pathology , Breast Neoplasms*/metabolism, Signal Transduction/drug effects ; Humans ; Female ; Animals |
| Περίληψη: | Purpose: This systematic review presents data on the role of polyphenols in autophagy in breast cancer. Methods: All research on polyphenol-induced autophagy in breast carcinoma was comprehensively searched in the electronic PubMed, Web of Science, Scopus, EMBASE, and Google Scholar databases up to January 1, 2025. The keywords were searched using the controlled vocabulary (Medical Subject Headings [MeSH]) with the terms Breast Cancer, polyphenols, and Autophagy. Following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, the systematic review and its findings were reported. Results: Of 742 related publications, a total of 359 items were omitted due to duplication. 58 studies were then manually screened. Ten studies were removed because of insufficient data (n = 6) or not focused on the topic (n = 4). Among the remaining studies (n = 48), 40 in vitro studies were found on breast cell lines and 8 in-vivo studies. Among the in vitro studies, curcumin demonstrated a strong ability to modulate the PI3K/AKT/mTOR pathway, enhancing autophagic flux and reducing cell viability. Resveratrol targeted the AMPK/mTOR signaling axis, showing consistent suppression of cancer stem-like cells and tumor growth inhibition in xenografted models. Carnosol induced autophagy independently of Beclin-1 by degrading STAT3 and downregulating p62, effectively inhibiting metastasis and tumor growth both in vitro and in vivo. Conclusions: Most reviewed studies describe in vitro results where polyphenols successfully induce autophagy under controlled in vitro conditions. However, this process is very tricky to translate into an in vivo setting and finally into clinical outcomes. (Copyright © 2026. Published by Elsevier GmbH.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Apoptosis; Autophagy; Breast cancer; Polyphenols |
| Substance Nomenclature: | 0 (Polyphenols) |
| Entry Date(s): | Date Created: 20260720 Date Completed: 20260812 Latest Revision: 20260826 |
| Update Code: | 20260826 |
| DOI: | 10.1016/j.prp.2026.156595 |
| PMID: | 42475944 |
| Βάση Δεδομένων: | MEDLINE |
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