Academic Journal
Repetitive neuronal activation regulates cellular maturation state via nuclear reprogramming.
| Τίτλος: | Repetitive neuronal activation regulates cellular maturation state via nuclear reprogramming. |
|---|---|
| Συγγραφείς: | Murano T; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Hagihara H; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Tajinda K; Astellas Research Institute of America, San Diego, CA, USA., Takao K; Department of Behavioral Physiology, Faculty of Medicine, University of Toyama, Toyama, Japan.; Research Center for Idling Brain Science, University of Toyama, Toyama, Japan., Takamiya Y; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan., Katoh K; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Ph.D. Program in Humanics, School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Japan.; The Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki, Japan.; Molecular Biosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases (NIID), Tokyo, Japan., Robison AJ; Department of Physiology and Neuroscience Program, Michigan State University, East Lansing, MI, USA., Matsumoto M; Astellas Research Institute of America, San Diego, CA, USA.; Arialys Therapeutics Inc., La Jolla, CA, USA., Namihira M; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Molecular Biosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.; Laboratory of Neural Regeneration and Brain Repair, Division of Biological Science, Graduate School of Science andTechnology, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara, Japan., Miyakawa T; Division of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan. miyakawa@fujita-hu.ac.jp. |
| Πηγή: | Nature communications [Nat Commun] 2026 Jul 17; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 17. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [London] : Nature Pub. Group |
| Ιατρικοί όροι (MeSH): | Neurons*/physiology , Neurons*/metabolism , Neurons*/cytology , Dentate Gyrus*/cytology , Dentate Gyrus*/physiology , Dentate Gyrus*/metabolism , Cellular Reprogramming*/physiology, Animals ; Mice ; Optogenetics ; Male ; Mice, Inbred C57BL ; Mice, Knockout |
| Περίληψη: | Neural stimulation, such as electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), is highly effective clinical intervention for a broad spectrum of psychiatric disorders, including depression and schizophrenia. However, their mechanism of action at the cellular level remains poorly understood. Here, we model ECT with repeated optogenetic neuronal stimulation in the mouse dentate gyrus, and observe ECT-relevant behavioral changes, including decreased depression-like behavior and increased locomotor activity. At the cellular level, we identify dematuration to a long-term stable state, persisting for more than one month, defined by changes in nuclear structure, gene expression patterns resembling the G (© 2026. The Author(s).) |
| Competing Interests: | Competing interests: The authors declare no competing interests. |
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| Grant Information: | JP21dm0207111 Japan Agency for Medical Research and Development (AMED); JP18dm0107101 Japan Agency for Medical Research and Development (AMED) |
| Molecular Sequence: | GEO GSE227200; GSE227201 SRA SRP241159 figshare 10.6084/m9.figshare.28853303 |
| Entry Date(s): | Date Created: 20260717 Date Completed: 20260717 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13379389 |
| DOI: | 10.1038/s41467-026-74202-w |
| PMID: | 42469214 |
| Βάση Δεδομένων: | MEDLINE |
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