Academic Journal
Essential Oils in Skin Tissue Engineering: Opportunities, Integration, and Overcoming Challenges.
| Title: | Essential Oils in Skin Tissue Engineering: Opportunities, Integration, and Overcoming Challenges. |
|---|---|
| Authors: | Emekdar E; Faculty of Chemical and Metallurgical Engineering, Bioengineering Department, Yildiz Technical University, Esenler, 34210, Istanbul, Turkey., Ari Yuka S; Faculty of Chemical and Metallurgical Engineering, Bioengineering Department, Yildiz Technical University, Esenler, 34210, Istanbul, Turkey.; Health Biotechnology Joint Research and Application Center of Excellence, Yildiz Technical University, Istanbul, Turkey., Erarslan A; Faculty of Chemical and Metallurgical Engineering, Bioengineering Department, Yildiz Technical University, Esenler, 34210, Istanbul, Turkey. azime@yildiz.edu.tr.; Health Biotechnology Joint Research and Application Center of Excellence, Yildiz Technical University, Istanbul, Turkey. azime@yildiz.edu.tr. |
| Source: | Tissue engineering and regenerative medicine [Tissue Eng Regen Med] 2026 Aug; Vol. 23 (6), pp. 771-789. Date of Electronic Publication: 2026 Jul 17. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Springer International Publishing co-published with Korean Tissue Engineering and Regenerative Medicine Country of Publication: Korea (South) NLM ID: 101699923 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-5469 (Electronic) Linking ISSN: 17382696 NLM ISO Abbreviation: Tissue Eng Regen Med Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Seoul : Springer International Publishing co-published with Korean Tissue Engineering and Regenerative Medicine, [2012]- |
| MeSH Terms: | Tissue Engineering*/methods , Oils, Volatile*/pharmacology , Oils, Volatile*/chemistry , Skin*/drug effects, Wound Healing/drug effects ; Humans ; Animals |
| Abstract: | Background: Essential oils (EOs) derived from plants have been utilized for the development of various approaches in biomedical applications due to their superior properties. In particular, their antimicrobial, anti-inflammatory, antioxidant, and wound-healing effects, alongside their biocompatibility and biodegradability, have made EOs a significant complementary agent in tissue regeneration-focused applications. Initial uses of EOs focused primarily on direct application and evaluation of their therapeutic efficacy; however, these approaches have been limited by issues such as volatility, instability, and potential for irritation. Methods: This review focuses on current perspectives in tissue engineering strategies, based on the biological functions of EO, such as biocompatibility, antimicrobial, anticancer, and antioxidant properties. Based on this comprehensive background of biological functions, current studies addressing nanoparticle systems, smart delivery systems, and wound dressings and coatings have been analyzed to identify existing issues and strategies to tackle these challenges. Results: In skin tissue engineering applications, innovative strategies such as nanoparticle encapsulation, integration into smart delivery systems, and the development of wound dressings containing EO have been developed. These advanced approaches offer advantages such as improved EO stability, controlled release, and enhanced efficacy, while also enriching the biofunctionality of the platform. While advanced delivery systems improve the stability of EOs, long-term stability under physiological and clinical conditions remains challenging. However, compared to conventional methods, these advancements strengthen the potential of EOs to drive tissue repair processes in a more controlled and functional manner. Conclusion: The integration of EO-based tissue engineering with nanotechnology offers a promising approach to optimizing the biological effects of these systems and enhancing the success of their application. Although challenges such as safety, biomaterial interactions, and scalability persist, recent advancements are rapidly overcoming these obstacles. EO-based strategies hold significant potential for overcoming current limitations and advancing the field, particularly in skin tissue engineering. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare that there is no conflict of interest regarding the publication of this paper. Ethical approval: There are no animal experiments carried out for this article. |
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| Contributed Indexing: | Keywords: Bioactive agents; Essential oils; Skin tissue engineering; Tissue regeneration; Wound healing |
| Substance Nomenclature: | 0 (Oils, Volatile) |
| Entry Date(s): | Date Created: 20260717 Date Completed: 20260729 Latest Revision: 20260731 |
| Update Code: | 20260731 |
| PubMed Central ID: | PMC13415709 |
| DOI: | 10.1007/s13770-026-00814-4 |
| PMID: | 42467367 |
| Database: | MEDLINE |
| FullText | Links: – Type: other Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=4F7895FEEB3C129B51AE&Show=Object Text: Availability: 0 CustomLinks: – Url: https://dx.doi.org/doi:10.1007/s13770-026-00814-4 Name: EDS - Springer Nature Journals (s7799221) Category: fullText Text: View record at Springer |
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| Items | – Name: Title Label: Title Group: Ti Data: Essential Oils in Skin Tissue Engineering: Opportunities, Integration, and Overcoming Challenges. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Emekdar+E%22">Emekdar E</searchLink>; Faculty of Chemical and Metallurgical Engineering, Bioengineering Department, Yildiz Technical University, Esenler, 34210, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Ari+Yuka+S%22">Ari Yuka S</searchLink>; Faculty of Chemical and Metallurgical Engineering, Bioengineering Department, Yildiz Technical University, Esenler, 34210, Istanbul, Turkey.; Health Biotechnology Joint Research and Application Center of Excellence, Yildiz Technical University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Erarslan+A%22">Erarslan A</searchLink>; Faculty of Chemical and Metallurgical Engineering, Bioengineering Department, Yildiz Technical University, Esenler, 34210, Istanbul, Turkey. azime@yildiz.edu.tr.; Health Biotechnology Joint Research and Application Center of Excellence, Yildiz Technical University, Istanbul, Turkey. azime@yildiz.edu.tr. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101699923%22">Tissue engineering and regenerative medicine</searchLink> [Tissue Eng Regen Med] 2026 Aug; Vol. 23 (6), pp. 771-789. <i>Date of Electronic Publication: </i>2026 Jul 17. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Review – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing+co-published+with+Korean+Tissue+Engineering+and+Regenerative+Medicine%22">Springer International Publishing co-published with Korean Tissue Engineering and Regenerative Medicine </searchLink><i>Country of Publication: </i>Korea (South) <i>NLM ID: </i>101699923 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2212-5469 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217382696%22">17382696 </searchLink><i>NLM ISO Abbreviation: </i>Tissue Eng Regen Med <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Original Publication</i>: Seoul : Springer International Publishing co-published with Korean Tissue Engineering and Regenerative Medicine, [2012]- – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Tissue+Engineering%22">Tissue Engineering*</searchLink>/<searchLink fieldCode="MM" term="%22Tissue+Engineering+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Oils%2C+Volatile%22">Oils, Volatile*</searchLink>/<searchLink fieldCode="MM" term="%22Oils%2C+Volatile+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Oils%2C+Volatile%22">Oils, Volatile*</searchLink>/<searchLink fieldCode="MM" term="%22Oils%2C+Volatile+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Skin%22">Skin*</searchLink>/<searchLink fieldCode="MM" term="%22Skin+drug+effects%22">drug effects</searchLink><br /><searchLink fieldCode="MH" term="%22Wound+Healing%22">Wound Healing</searchLink>/<searchLink fieldCode="MH" term="%22Wound+Healing+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Essential oils (EOs) derived from plants have been utilized for the development of various approaches in biomedical applications due to their superior properties. In particular, their antimicrobial, anti-inflammatory, antioxidant, and wound-healing effects, alongside their biocompatibility and biodegradability, have made EOs a significant complementary agent in tissue regeneration-focused applications. Initial uses of EOs focused primarily on direct application and evaluation of their therapeutic efficacy; however, these approaches have been limited by issues such as volatility, instability, and potential for irritation.<br />Methods: This review focuses on current perspectives in tissue engineering strategies, based on the biological functions of EO, such as biocompatibility, antimicrobial, anticancer, and antioxidant properties. Based on this comprehensive background of biological functions, current studies addressing nanoparticle systems, smart delivery systems, and wound dressings and coatings have been analyzed to identify existing issues and strategies to tackle these challenges.<br />Results: In skin tissue engineering applications, innovative strategies such as nanoparticle encapsulation, integration into smart delivery systems, and the development of wound dressings containing EO have been developed. These advanced approaches offer advantages such as improved EO stability, controlled release, and enhanced efficacy, while also enriching the biofunctionality of the platform. While advanced delivery systems improve the stability of EOs, long-term stability under physiological and clinical conditions remains challenging. However, compared to conventional methods, these advancements strengthen the potential of EOs to drive tissue repair processes in a more controlled and functional manner.<br />Conclusion: The integration of EO-based tissue engineering with nanotechnology offers a promising approach to optimizing the biological effects of these systems and enhancing the success of their application. Although challenges such as safety, biomaterial interactions, and scalability persist, recent advancements are rapidly overcoming these obstacles. EO-based strategies hold significant potential for overcoming current limitations and advancing the field, particularly in skin tissue engineering.<br /> (© 2026. The Author(s).) – Name: Abstract Label: Competing Interests Group: Ab Data: Declarations. Conflict of interest: The authors declare that there is no conflict of interest regarding the publication of this paper. 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(PMID: <searchLink fieldCode="PM" term="%2210%2E1016%2Fj%2Ebiopen%2E2017%2E04%2E001294501505805555%22">10.1016/j.biopen.2017.04.001294501505805555)</searchLink> – Name: SubjectMinor Label: Contributed Indexing Group: Data: <i>Keywords: </i>Bioactive agents; Essential oils; Skin tissue engineering; Tissue regeneration; Wound healing – Name: NumberCAS Label: Substance Nomenclature Group: ID Data: 0 (Oils, Volatile) – Name: DateEntry Label: Entry Date(s) Group: Date Data: <i>Date Created: </i>20260717 <i>Date Completed: </i>20260729 <i>Latest Revision: </i>20260731 – Name: DateUpdate Label: Update Code Group: Date Data: 20260731 – Name: PubmedCentralID Label: PubMed Central ID Group: ID Data: PMC13415709 – Name: DOI Label: DOI Group: ID Data: 10.1007/s13770-026-00814-4 – Name: AN Label: PMID Group: ID Data: 42467367 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s13770-026-00814-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 771 Subjects: – SubjectFull: Wound Healing drug effects Type: general – SubjectFull: Humans Type: general – SubjectFull: Animals Type: general – SubjectFull: Tissue Engineering methods Type: general – SubjectFull: Oils, Volatile pharmacology Type: general – SubjectFull: Oils, Volatile chemistry Type: general – SubjectFull: Skin drug effects Type: general Titles: – TitleFull: Essential Oils in Skin Tissue Engineering: Opportunities, Integration, and Overcoming Challenges. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Emekdar E – PersonEntity: Name: NameFull: Ari Yuka S – PersonEntity: Name: NameFull: Erarslan A IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2026 Aug Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2212-5469 Numbering: – Type: volume Value: 23 – Type: issue Value: 6 Titles: – TitleFull: Tissue engineering and regenerative medicine Type: main |
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