Academic Journal
Impact of steroid treatment for Bell's palsy on Glycemic control in patients with type 2 diabetes mellitus.
| Τίτλος: | Impact of steroid treatment for Bell's palsy on Glycemic control in patients with type 2 diabetes mellitus. |
|---|---|
| Συγγραφείς: | Lorenz FJ; Department of Otolaryngology-Head and Neck Surgery, Penn State College of Medicine, Hershey, PA, United States of America., Ma C; Department of Otolaryngology-Head and Neck Surgery, Penn State College of Medicine, Hershey, PA, United States of America., Kang Y; Department of Otolaryngology-Head and Neck Surgery, Penn State College of Medicine, Hershey, PA, United States of America., Diez EDT; Department of Otolaryngology-Head and Neck Surgery, Penn State College of Medicine, Hershey, PA, United States of America., Schopper HK; Department of Otolaryngology-Head and Neck Surgery, Penn State College of Medicine, Hershey, PA, United States of America., Lighthall JG; Department of Otolaryngology-Head and Neck Surgery, Penn State College of Medicine, Hershey, PA, United States of America. Electronic address: jlighthall@pennstatehealth.psu.edu. |
| Πηγή: | The American journal of emergency medicine [Am J Emerg Med] 2026 Oct; Vol. 108, pp. 155-161. Date of Electronic Publication: 2026 Jul 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: W B Saunders Country of Publication: United States NLM ID: 8309942 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8171 (Electronic) Linking ISSN: 07356757 NLM ISO Abbreviation: Am J Emerg Med Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1983- : Philadelphia, PA : W B Saunders Original Publication: [Philadelphia, PA. : Centrum Philadelphia, c1983]- |
| Ιατρικοί όροι (MeSH): | Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/blood , Bell Palsy*/drug therapy , Bell Palsy*/complications , Adrenal Cortex Hormones*/therapeutic use , Adrenal Cortex Hormones*/adverse effects , Glycemic Control*, Glycated Hemoglobin/analysis ; Hyperglycemia/chemically induced ; Diabetic Ketoacidosis/epidemiology ; Diabetic Ketoacidosis/chemically induced ; Humans ; Female ; Retrospective Studies ; Male ; Middle Aged ; Blood Glucose ; Aged |
| Περίληψη: | Introduction: Corticosteroids are the primary treatment for Bell's palsy, but use in patients with type 2 diabetes mellitus (T2DM) is often limited by hyperglycemia concerns. This study assessed steroid-associated glycemic outcomes in diabetic Bell's palsy patients. Methods: This retrospective cohort study used the TriNetX Research Network to identify patients diagnosed with Bell's palsy from 2010 to 2024. Patients were stratified by T2DM status and receipt of systemic corticosteroids within 10 days of diagnosis. Propensity score matching was performed on age, sex, race, ethnicity, diabetes medications, and comorbidities. The primary outcome was the most recent glucose within 1-30 days post-diagnosis. Secondary outcomes were the most recent HbA1c within 1-6 months post-diagnosis and rates of diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS) within 3 months. Results: Among 6268 patients with Bell's palsy and T2DM, steroid-treated patients had higher glucose within 1-30 days post-diagnosis (162.4 vs. 152.4 mg/dL; P < 0.001). HbA1c within 1-6 months did not differ significantly (7.24% vs. 7.20%; P = 0.43). DKA rates did not differ significantly (1.10% vs. 0.84%; P = 0.32), and HHS occurred at a higher rate in steroid-treated T2DM patients (1.82% vs. 0.57%; P < 0.001; number needed to harm = 80). Conclusion: Corticosteroids for Bell's palsy in T2DM are associated with a small absolute increase in acute glucose and HHS risk, while HbA1c and DKA rates were not significantly different. As a hypothesis-generating study, prospective data are needed before definitive recommendations can be made; however, these results may support emergency clinicians in initiating timely steroid therapy with appropriate glucose monitoring at discharge. (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors report no conflicts of interest. |
| Contributed Indexing: | Keywords: Bell's palsy; Corticosteroids; Glycemic control; HbA1c; Hyperglycemia; Metabolic complications; Type 2 diabetes |
| Substance Nomenclature: | 0 (Adrenal Cortex Hormones) 0 (Glycated Hemoglobin) 0 (Blood Glucose) |
| Entry Date(s): | Date Created: 20260715 Date Completed: 20260827 Latest Revision: 20260827 |
| Update Code: | 20260828 |
| DOI: | 10.1016/j.ajem.2026.06.048 |
| PMID: | 42456542 |
| Βάση Δεδομένων: | MEDLINE |
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