Academic Journal
Intermittent fasting increases plasma arachidonic acid.
| Τίτλος: | Intermittent fasting increases plasma arachidonic acid. |
|---|---|
| Συγγραφείς: | Kahle N; Medical Department B, Division of Hepatology, Gastroenterology, Oncology, Hematology, Palliative Care, Endocrinology and Diabetes, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany; Nutrition Skills Lab, Brandenburg Medical School (MHB), Neuruppin, Germany; Faculty of Health Sciences Brandenburg, Joint Faculty of the University of Potsdam, Brandenburg University of Technology Cottbus-Senftenberg and Brandenburg Medical School Theodor Fontane (MHB), Potsdam, Germany. Electronic address: nina.kahle@mhb-fontane.de., Kunkel S; Medical Department B, Division of Hepatology, Gastroenterology, Oncology, Hematology, Palliative Care, Endocrinology and Diabetes, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany; Nutrition Skills Lab, Brandenburg Medical School (MHB), Neuruppin, Germany; Faculty of Health Sciences Brandenburg, Joint Faculty of the University of Potsdam, Brandenburg University of Technology Cottbus-Senftenberg and Brandenburg Medical School Theodor Fontane (MHB), Potsdam, Germany., Böttcher S; Medical Department B, Division of Hepatology, Gastroenterology, Oncology, Hematology, Palliative Care, Endocrinology and Diabetes, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany; Nutrition Skills Lab, Brandenburg Medical School (MHB), Neuruppin, Germany; Faculty of Health Sciences Brandenburg, Joint Faculty of the University of Potsdam, Brandenburg University of Technology Cottbus-Senftenberg and Brandenburg Medical School Theodor Fontane (MHB), Potsdam, Germany; Department of Gastroenterology, Rheumatology and Infectiology, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany., Yu Y; Medical Department B, Division of Hepatology, Gastroenterology, Oncology, Hematology, Palliative Care, Endocrinology and Diabetes, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany; Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany., Pietzner A; Medical Department B, Division of Hepatology, Gastroenterology, Oncology, Hematology, Palliative Care, Endocrinology and Diabetes, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany; Nutrition Skills Lab, Brandenburg Medical School (MHB), Neuruppin, Germany., Weylandt KH; Medical Department B, Division of Hepatology, Gastroenterology, Oncology, Hematology, Palliative Care, Endocrinology and Diabetes, Brandenburg Medical School, University Hospital Ruppin-Brandenburg, Neuruppin, Germany; Nutrition Skills Lab, Brandenburg Medical School (MHB), Neuruppin, Germany; Faculty of Health Sciences Brandenburg, Joint Faculty of the University of Potsdam, Brandenburg University of Technology Cottbus-Senftenberg and Brandenburg Medical School Theodor Fontane (MHB), Potsdam, Germany. Electronic address: karsten.weylandt@mhb-fontane.de. |
| Πηγή: | Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2026 Oct; Vol. 210, pp. 102760. Date of Electronic Publication: 2026 Jul 11. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 8802730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2823 (Electronic) Linking ISSN: 09523278 NLM ISO Abbreviation: Prostaglandins Leukot Essent Fatty Acids Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Edinburgh ; New York : Churchill Livingstone, c1988- |
| Ιατρικοί όροι (MeSH): | Arachidonic Acid*/blood , Overweight*/blood , Overweight*/diet therapy , Obesity*/blood , Obesity*/diet therapy , Fasting*/blood , Intermittent Fasting*, Fatty Acids, Omega-6/blood ; Fatty Acids, Omega-3/blood ; Eicosapentaenoic Acid/blood ; Humans ; Female ; Male ; Adult ; Body Mass Index ; Middle Aged ; Delta-5 Fatty Acid Desaturase |
| Περίληψη: | Objective: Intermittent fasting (IF) has emerged as a dietary intervention with potential effects on metabolic health and inflammatory processes. However, clinical evidence for its benefits remains inconsistent, despite numerous biochemical indications. Polyunsaturated fatty acids (PUFAs), as precursors of bioactive lipid mediators, may represent a potential mechanism through which dietary interventions such as IF exert anti-inflammatory and metabolic effects. Therefore, we investigated changes in blood fatty acid (FA) composition and associated metabolic endpoints during IF. Methods: Thirty-nine normal-weight and overweight/obese participants followed a 16:8 IF regimen. Body weight, body mass index (BMI), routine lipid and liver parameters, and blood FA composition, quantified by gas chromatography with flame ionization detection (GC-FID), with a focus on omega-6 and omega-3 PUFAs (n-6 and n-3 PUFAs), were assessed at baseline and after 4 weeks. Results: IF induced plasma FA mobilization and a higher n-6/n-3 ratio in normal-weight participants. Across the cohort, arachidonic acid (AA) and the Delta-5-desaturase (D5D) index increased while the eicosapentaenoic acid/AA (EPA/AA) ratio decreased. Red blood cell FA composition remained largely unchanged. In contrast, overweight/obese participants showed minimal changes in FA profiles but significant metabolic improvements, including reductions in body weight, BMI, liver fat content, and γ-glutamyl transferase (GGT). Conclusion: IF results in weight-dependent alterations in plasma FAs. Normal-weight individuals showed a predominance of n-6 PUFAs, whereas FA profiles in overweight/obese participants remained stable despite metabolic improvements. Overall, IF may exert a more pronounced effect on inflammatory pathways in normal-weight individuals, reflected by increased availability of AA, whose inflammatory significance remains unclear. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Arachidonic acid; Fatty acids; Inflammation; Metabolic health; intermittent fasting |
| Substance Nomenclature: | 27YG812J1I (Arachidonic Acid) 0 (Fatty Acids, Omega-6) 0 (Fatty Acids, Omega-3) AAN7QOV9EA (Eicosapentaenoic Acid) 0 (Delta-5 Fatty Acid Desaturase) |
| Entry Date(s): | Date Created: 20260715 Date Completed: 20260910 Latest Revision: 20260910 |
| Update Code: | 20260911 |
| DOI: | 10.1016/j.plefa.2026.102760 |
| PMID: | 42456402 |
| Βάση Δεδομένων: | MEDLINE |
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