Tissue-Specific Phytochemical Profiling and Bioactivity of Ricinus communis L. Under Varying Agronomic Conditions.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Tissue-Specific Phytochemical Profiling and Bioactivity of Ricinus communis L. Under Varying Agronomic Conditions.
Συγγραφείς: Guzel Y; Department of Field Crops, Faculty of Agriculture, University of Dicle, Diyarbakır, Türkiye., Basbag S; Department of Field Crops, Faculty of Agriculture, University of Dicle, Diyarbakır, Türkiye., Tarhan A; Dicle University Science and Technology Application and Research Center, Diyarbakir, Türkiye., Yener I; Department of Analytical Chemistry, Faculty of Pharmacy, University of Dicle, Diyarbakir, Türkiye.
Πηγή: Chemistry & biodiversity [Chem Biodivers] 2026 Jul; Vol. 23 (7), pp. e71495.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE
Imprint Name(s): Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-
Ιατρικοί όροι (MeSH): Ricinus*/chemistry , Ricinus*/metabolism , Phytochemicals*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/isolation & purification , Antioxidants*/chemistry , Antioxidants*/pharmacology , Antioxidants*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/isolation & purification, alpha-Glucosidases/metabolism ; Urease/metabolism ; Urease/antagonists & inhibitors ; Plant Components, Aerial/chemistry ; Plant Components, Aerial/metabolism ; Tandem Mass Spectrometry
Περίληψη: Natural bioactive compounds have emerged as essential candidates for pharmaceutical development due to their high efficacy and low toxicity. Hence, this study was designed to evaluate how varying sowing dates and nitrogen treatments influence the phytochemical profile and biological activity of Ricinus communis L. Quantitative LC-MS/MS profiling of the aerial parts established quinic acid (94.789 mg/g), ellagic acid (39.955 mg/g), and gallic acid (35.732 mg/g) as the major phenolic-flavonoid compounds in the extract. The extracts exhibited strong antioxidant potential, with determined values of 37.35 ± 0.32 µg/mL (DPPH IC50), 13.05 ± 0.08 µg/mL (ABTS IC50), and 30.93 ± 0.56 µg/mL (CUPRAC A0.5). Enzymatic assays revealed tissue-specific inhibition, with the aerial parts targeting urease (66.44% ± 0.67%) and collagenase (47.61% ± 0.82%), and the seeds predominantly affecting α-glucosidase (97.12% ± 1.69%) and AChE (55.37% ± 0.89%). In conclusion, this study bridges agronomy and pharmacology by demonstrating that sowing dates and nitrogen treatments determine phytochemical yield. Furthermore, it reveals a novel, tissue-specific divergence, as the aerial parts and seeds of R. communis target completely distinct enzymatic pathways.
(© 2026 Wiley‐VHCA AG.)
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Grant Information: ZİRAAT.23.026 Dicle University Scientific Research Projects Coordination Unit
Contributed Indexing: Keywords: LC–MS/MS; R. communis; antioxidant activities; ellagic acid; phenolic compounds; α‐glucosidase
Substance Nomenclature: 0 (Phytochemicals)
0 (Antioxidants)
EC 3.2.1.20 (alpha-Glucosidases)
0 (Plant Extracts)
0 (Enzyme Inhibitors)
EC 3.5.1.5 (Urease)
Entry Date(s): Date Created: 20260715 Date Completed: 20260715 Latest Revision: 20260813
Update Code: 20260814
PubMed Central ID: PMC13372045
DOI: 10.1002/cbdv.71495
PMID: 42455647
Βάση Δεδομένων: MEDLINE