Academic Journal
Harnessing genetic, chemical, and transcriptomic analyses guided the selection of Cistus creticus subsp. creticus genotypes rich in labdane-type diterpenes.
| Τίτλος: | Harnessing genetic, chemical, and transcriptomic analyses guided the selection of Cistus creticus subsp. creticus genotypes rich in labdane-type diterpenes. |
|---|---|
| Συγγραφείς: | Kostas S; Laboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. skostas@agro.auth.gr., Ntoanidou S; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. sntoa@pharm.auth.gr., Bazakos C; Institute of Plant Breeding and Genetic Resources, ELGO-DIMITRA, Thessaloniki-Thermi, Greece.; Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Carl-Von-Linne-Weg 10, 50829, Cologne, Germany., Sarrou E; Institute of Plant Breeding and Genetic Resources, ELGO-DIMITRA, Thessaloniki-Thermi, Greece., Rafailidou N; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece., Papanikolaou A; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece., Makris A; Institute of Applied Biosciences, Centre for Research and Technology Hellas (INAB-CERTH), P.O. Box 60361, Thermi, 57001, Thessaloniki, Greece., Kotoula AA; Laboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece., Hatziloukas E; Laboratory of Molecular Biology and Genetics, Department of Biological Applications and Technologies, University of Ioannina, 45110, Ioannina, Greece., Economou A; Laboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece., Kanellis AK; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. kanellis@pharm.auth.gr. |
| Πηγή: | Planta [Planta] 2026 Jul 15; Vol. 264 (2). Date of Electronic Publication: 2026 Jul 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag [etc.] Country of Publication: Germany NLM ID: 1250576 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-2048 (Electronic) Linking ISSN: 00320935 NLM ISO Abbreviation: Planta Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin, New York, Springer-Verlag [etc.] |
| Ιατρικοί όροι (MeSH): | Diterpenes*/metabolism , Diterpenes*/chemistry , Cistus*/genetics , Cistus*/metabolism , Cistus*/chemistry, Genotype ; Gene Expression Profiling ; Genetic Variation ; Transcriptome ; Gene Expression Regulation, Plant ; Greece |
| Περίληψη: | Main Conclusion: The present study connects the genetic diversity of Cistus creticus to its chemical profile, identifying elite genotypes and key biosynthetic genes for enhancing the production of valuable labdane diterpenes. Cistus creticus, a Mediterranean shrub, is known for its resin ladano, which is rich in pharmacologically active labdane-related diterpenes (LRDs). However, the genetic and molecular basis for the LRDs content variation among natural populations remains uncharacterized. This study aims to fulfill this lacuna by investigating a potential link between genetic diversity and chemotypic profile across 91 genotypes from seven different populations across Greece and identifying elite germplasm by uncovering the molecular and regulatory mechanisms underlying LRDs biosynthesis. The genetic analysis, employing ISSR markers, revealed significant genetic differentiation among populations (Φ (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
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| Grant Information: | T1EDK-03919 RESEARCH-CREATE-INNOVATE |
| Contributed Indexing: | Keywords: GC–MS; Gene expression; ISSR; Ladano; Molecular markers |
| Substance Nomenclature: | 0 (Diterpenes) 0 (labdane) |
| Entry Date(s): | Date Created: 20260715 Date Completed: 20260715 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13372853 |
| DOI: | 10.1007/s00425-026-05072-1 |
| PMID: | 42455372 |
| Βάση Δεδομένων: | MEDLINE |
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