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Harnessing genetic, chemical, and transcriptomic analyses guided the selection of Cistus creticus subsp. creticus genotypes rich in labdane-type diterpenes.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Harnessing genetic, chemical, and transcriptomic analyses guided the selection of Cistus creticus subsp. creticus genotypes rich in labdane-type diterpenes.
Συγγραφείς: Kostas S; Laboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. skostas@agro.auth.gr., Ntoanidou S; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. sntoa@pharm.auth.gr., Bazakos C; Institute of Plant Breeding and Genetic Resources, ELGO-DIMITRA, Thessaloniki-Thermi, Greece.; Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Carl-Von-Linne-Weg 10, 50829, Cologne, Germany., Sarrou E; Institute of Plant Breeding and Genetic Resources, ELGO-DIMITRA, Thessaloniki-Thermi, Greece., Rafailidou N; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece., Papanikolaou A; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece., Makris A; Institute of Applied Biosciences, Centre for Research and Technology Hellas (INAB-CERTH), P.O. Box 60361, Thermi, 57001, Thessaloniki, Greece., Kotoula AA; Laboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece., Hatziloukas E; Laboratory of Molecular Biology and Genetics, Department of Biological Applications and Technologies, University of Ioannina, 45110, Ioannina, Greece., Economou A; Laboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece., Kanellis AK; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. kanellis@pharm.auth.gr.
Πηγή: Planta [Planta] 2026 Jul 15; Vol. 264 (2). Date of Electronic Publication: 2026 Jul 15.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer-Verlag [etc.] Country of Publication: Germany NLM ID: 1250576 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-2048 (Electronic) Linking ISSN: 00320935 NLM ISO Abbreviation: Planta Subsets: MEDLINE
Imprint Name(s): Original Publication: Berlin, New York, Springer-Verlag [etc.]
Ιατρικοί όροι (MeSH): Diterpenes*/metabolism , Diterpenes*/chemistry , Cistus*/genetics , Cistus*/metabolism , Cistus*/chemistry, Genotype ; Gene Expression Profiling ; Genetic Variation ; Transcriptome ; Gene Expression Regulation, Plant ; Greece
Περίληψη: Main Conclusion: The present study connects the genetic diversity of Cistus creticus to its chemical profile, identifying elite genotypes and key biosynthetic genes for enhancing the production of valuable labdane diterpenes. Cistus creticus, a Mediterranean shrub, is known for its resin ladano, which is rich in pharmacologically active labdane-related diterpenes (LRDs). However, the genetic and molecular basis for the LRDs content variation among natural populations remains uncharacterized. This study aims to fulfill this lacuna by investigating a potential link between genetic diversity and chemotypic profile across 91 genotypes from seven different populations across Greece and identifying elite germplasm by uncovering the molecular and regulatory mechanisms underlying LRDs biosynthesis. The genetic analysis, employing ISSR markers, revealed significant genetic differentiation among populations (ΦST = 0.294) that mirrored distinct chemotypic profiles. Genotypes clustered by origin with Chalkidiki and Sises being the most homogenous, high-yielding, and superior in LRDs production. The transcriptomic analysis of low (C1) vs. high (C18) LRDs genotypes identified 24,489 up-regulated genes, including key diterpene synthases [labda-7,13-dien-15-ol synthase (LDDS2), ent-copalyl diphosphate synthase, copal-8-ol diphosphate synthase (CLS)] and numerous transcription factors among which WRKY, bHLH and bZIP were strongly correlated with LRD accumulation. This work provides an initial representation of the regulatory landscape by identifying elite genotypes, key biosynthetic genes, and transcription factors linked to specific LRDs for promising breeding programs, future targeted experiments, and metabolic engineering.
(© 2026. The Author(s).)
Competing Interests: Declarations. Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
References: Bioinformatics. 2012 Oct 1;28(19):2537-9. (PMID: 22820204)
Genes (Basel). 2023 Apr 21;14(4):. (PMID: 37107709)
Nat Commun. 2016 Oct 05;7:12942. (PMID: 27703160)
Curr Med Chem. 2005;12(11):1295-317. (PMID: 15974998)
Planta Med. 1997 Oct;63(5):477-9. (PMID: 9342956)
Plants (Basel). 2021 Aug 06;10(8):. (PMID: 34451664)
Curr Issues Mol Biol. 2024 Sep 23;46(9):10677-10695. (PMID: 39329985)
Planta. 2017 Aug;246(2):201-215. (PMID: 28314999)
PLoS One. 2011 Feb 14;6(2):e17172. (PMID: 21347265)
Fly (Austin). 2012 Apr-Jun;6(2):80-92. (PMID: 22728672)
Chin J Nat Med. 2022 Oct;20(10):761-772. (PMID: 36307198)
Front Chem. 2014 Jun 11;2:35. (PMID: 24967222)
Planta. 2018 Feb;247(2):289-300. (PMID: 29218421)
Chemosphere. 2010 Feb;78(8):942-9. (PMID: 20092868)
Sci Rep. 2018 Jul 20;8(1):11009. (PMID: 30030474)
Plant Physiol. 2010 Sep;154(1):301-10. (PMID: 20595348)
Z Naturforsch C J Biosci. 2002 Jan-Feb;57(1-2):89-94. (PMID: 11926549)
Biomed Pharmacother. 2006 May;60(4):191-9. (PMID: 16675195)
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549. (PMID: 29722887)
Trends Plant Sci. 2021 May;26(5):472-483. (PMID: 33478816)
Mol Ecol. 2005 Jul;14(8):2611-20. (PMID: 15969739)
Mol Phylogenet Evol. 2005 Dec;37(3):644-60. (PMID: 16055353)
J Exp Bot. 2024 Jun 7;75(11):3431-3451. (PMID: 38520311)
Pharmacol Res. 2006 Jan;53(1):80-7. (PMID: 16253514)
Nat Prod Res. 2017 Feb;31(3):299-307. (PMID: 27681295)
Sci Rep. 2017 Nov 22;7(1):16074. (PMID: 29167468)
Mol Phylogenet Evol. 2009 Aug;52(2):538-43. (PMID: 19364536)
Theor Appl Genet. 2019 Mar;132(3):627-645. (PMID: 30824972)
Planta Med. 1999 Dec;65(8):735-9. (PMID: 10630116)
Plant Physiol. 2003 Apr;131(4):1868-76. (PMID: 12692346)
J Chromatogr. 1963 Aug;11:463-71. (PMID: 14062605)
Plant Mol Biol. 2014 Sep;86(1-2):171-83. (PMID: 25033935)
Genome Res. 2003 Nov;13(11):2498-504. (PMID: 14597658)
PLoS One. 2015 May 28;10(5):e0124106. (PMID: 26020634)
Phytochemistry. 2009 Jun;70(9):1146-1160. (PMID: 19660770)
Nat Protoc. 2013 Aug;8(8):1494-512. (PMID: 23845962)
Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: 19505943)
Genes (Basel). 2022 Nov 19;13(11):. (PMID: 36421835)
J Biol Chem. 2009 Sep 25;284(39):26510-8. (PMID: 19635799)
Plant J. 2015 Dec;84(6):1100-13. (PMID: 26506081)
Anal Bioanal Chem. 2016 May;408(12):3295-307. (PMID: 26922339)
Genetica. 2010 Feb;138(2):241-9. (PMID: 19844793)
Grant Information: T1EDK-03919 RESEARCH-CREATE-INNOVATE
Contributed Indexing: Keywords: GC–MS; Gene expression; ISSR; Ladano; Molecular markers
Substance Nomenclature: 0 (Diterpenes)
0 (labdane)
Entry Date(s): Date Created: 20260715 Date Completed: 20260715 Latest Revision: 20260813
Update Code: 20260814
PubMed Central ID: PMC13372853
DOI: 10.1007/s00425-026-05072-1
PMID: 42455372
Βάση Δεδομένων: MEDLINE
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  Data: Harnessing genetic, chemical, and transcriptomic analyses guided the selection of Cistus creticus subsp. creticus genotypes rich in labdane-type diterpenes.
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  Data: <searchLink fieldCode="AU" term="%22Kostas+S%22">Kostas S</searchLink>; Laboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. skostas@agro.auth.gr.<br /><searchLink fieldCode="AU" term="%22Ntoanidou+S%22">Ntoanidou S</searchLink>; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. sntoa@pharm.auth.gr.<br /><searchLink fieldCode="AU" term="%22Bazakos+C%22">Bazakos C</searchLink>; Institute of Plant Breeding and Genetic Resources, ELGO-DIMITRA, Thessaloniki-Thermi, Greece.; Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research, Carl-Von-Linne-Weg 10, 50829, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Sarrou+E%22">Sarrou E</searchLink>; Institute of Plant Breeding and Genetic Resources, ELGO-DIMITRA, Thessaloniki-Thermi, Greece.<br /><searchLink fieldCode="AU" term="%22Rafailidou+N%22">Rafailidou N</searchLink>; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Papanikolaou+A%22">Papanikolaou A</searchLink>; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Makris+A%22">Makris A</searchLink>; Institute of Applied Biosciences, Centre for Research and Technology Hellas (INAB-CERTH), P.O. Box 60361, Thermi, 57001, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Kotoula+AA%22">Kotoula AA</searchLink>; Laboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Hatziloukas+E%22">Hatziloukas E</searchLink>; Laboratory of Molecular Biology and Genetics, Department of Biological Applications and Technologies, University of Ioannina, 45110, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Economou+A%22">Economou A</searchLink>; Laboratory of Floriculture, Department of Horticulture, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Kanellis+AK%22">Kanellis AK</searchLink>; Group of Biotechnology of Pharmaceutical Plants, Laboratory of Pharmacognosy, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. kanellis@pharm.auth.gr.
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  Data: <searchLink fieldCode="MM" term="%22Diterpenes%22">Diterpenes*</searchLink>/<searchLink fieldCode="MM" term="%22Diterpenes+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Diterpenes%22">Diterpenes*</searchLink>/<searchLink fieldCode="MM" term="%22Diterpenes+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Cistus%22">Cistus*</searchLink>/<searchLink fieldCode="MM" term="%22Cistus+genetics%22">genetics</searchLink> <br /><searchLink fieldCode="MM" term="%22Cistus%22">Cistus*</searchLink>/<searchLink fieldCode="MM" term="%22Cistus+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Cistus%22">Cistus*</searchLink>/<searchLink fieldCode="MM" term="%22Cistus+chemistry%22">chemistry</searchLink><br /><searchLink fieldCode="MH" term="%22Genotype%22">Genotype</searchLink> ; <searchLink fieldCode="MH" term="%22Gene+Expression+Profiling%22">Gene Expression Profiling</searchLink> ; <searchLink fieldCode="MH" term="%22Genetic+Variation%22">Genetic Variation</searchLink> ; <searchLink fieldCode="MH" term="%22Transcriptome%22">Transcriptome</searchLink> ; <searchLink fieldCode="MH" term="%22Gene+Expression+Regulation%2C+Plant%22">Gene Expression Regulation, Plant</searchLink> ; <searchLink fieldCode="MH" term="%22Greece%22">Greece</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Main Conclusion: The present study connects the genetic diversity of Cistus creticus to its chemical profile, identifying elite genotypes and key biosynthetic genes for enhancing the production of valuable labdane diterpenes. Cistus creticus, a Mediterranean shrub, is known for its resin ladano, which is rich in pharmacologically active labdane-related diterpenes (LRDs). However, the genetic and molecular basis for the LRDs content variation among natural populations remains uncharacterized. This study aims to fulfill this lacuna by investigating a potential link between genetic diversity and chemotypic profile across 91 genotypes from seven different populations across Greece and identifying elite germplasm by uncovering the molecular and regulatory mechanisms underlying LRDs biosynthesis. The genetic analysis, employing ISSR markers, revealed significant genetic differentiation among populations (Φ<subscript>ST</subscript> = 0.294) that mirrored distinct chemotypic profiles. Genotypes clustered by origin with Chalkidiki and Sises being the most homogenous, high-yielding, and superior in LRDs production. The transcriptomic analysis of low (C1) vs. high (C18) LRDs genotypes identified 24,489 up-regulated genes, including key diterpene synthases [labda-7,13-dien-15-ol synthase (LDDS2), ent-copalyl diphosphate synthase, copal-8-ol diphosphate synthase (CLS)] and numerous transcription factors among which WRKY, bHLH and bZIP were strongly correlated with LRD accumulation. This work provides an initial representation of the regulatory landscape by identifying elite genotypes, key biosynthetic genes, and transcription factors linked to specific LRDs for promising breeding programs, future targeted experiments, and metabolic engineering.<br /> (© 2026. The Author(s).)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Conflict of interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Bioinformatics. 2012 Oct 1;28(19):2537-9. (PMID: <searchLink fieldCode="PM" term="%2222820204%22">22820204)</searchLink><br />Genes (Basel). 2023 Apr 21;14(4):. (PMID: <searchLink fieldCode="PM" term="%2237107709%22">37107709)</searchLink><br />Nat Commun. 2016 Oct 05;7:12942. (PMID: <searchLink fieldCode="PM" term="%2227703160%22">27703160)</searchLink><br />Curr Med Chem. 2005;12(11):1295-317. (PMID: <searchLink fieldCode="PM" term="%2215974998%22">15974998)</searchLink><br />Planta Med. 1997 Oct;63(5):477-9. (PMID: <searchLink fieldCode="PM" term="%229342956%22">9342956)</searchLink><br />Plants (Basel). 2021 Aug 06;10(8):. (PMID: <searchLink fieldCode="PM" term="%2234451664%22">34451664)</searchLink><br />Curr Issues Mol Biol. 2024 Sep 23;46(9):10677-10695. (PMID: <searchLink fieldCode="PM" term="%2239329985%22">39329985)</searchLink><br />Planta. 2017 Aug;246(2):201-215. (PMID: <searchLink fieldCode="PM" term="%2228314999%22">28314999)</searchLink><br />PLoS One. 2011 Feb 14;6(2):e17172. (PMID: <searchLink fieldCode="PM" term="%2221347265%22">21347265)</searchLink><br />Fly (Austin). 2012 Apr-Jun;6(2):80-92. (PMID: <searchLink fieldCode="PM" term="%2222728672%22">22728672)</searchLink><br />Chin J Nat Med. 2022 Oct;20(10):761-772. (PMID: <searchLink fieldCode="PM" term="%2236307198%22">36307198)</searchLink><br />Front Chem. 2014 Jun 11;2:35. (PMID: <searchLink fieldCode="PM" term="%2224967222%22">24967222)</searchLink><br />Planta. 2018 Feb;247(2):289-300. (PMID: <searchLink fieldCode="PM" term="%2229218421%22">29218421)</searchLink><br />Chemosphere. 2010 Feb;78(8):942-9. (PMID: <searchLink fieldCode="PM" term="%2220092868%22">20092868)</searchLink><br />Sci Rep. 2018 Jul 20;8(1):11009. (PMID: <searchLink fieldCode="PM" term="%2230030474%22">30030474)</searchLink><br />Plant Physiol. 2010 Sep;154(1):301-10. (PMID: <searchLink fieldCode="PM" term="%2220595348%22">20595348)</searchLink><br />Z Naturforsch C J Biosci. 2002 Jan-Feb;57(1-2):89-94. (PMID: <searchLink fieldCode="PM" term="%2211926549%22">11926549)</searchLink><br />Biomed Pharmacother. 2006 May;60(4):191-9. (PMID: <searchLink fieldCode="PM" term="%2216675195%22">16675195)</searchLink><br />Mol Biol Evol. 2018 Jun 1;35(6):1547-1549. (PMID: <searchLink fieldCode="PM" term="%2229722887%22">29722887)</searchLink><br />Trends Plant Sci. 2021 May;26(5):472-483. (PMID: <searchLink fieldCode="PM" term="%2233478816%22">33478816)</searchLink><br />Mol Ecol. 2005 Jul;14(8):2611-20. (PMID: <searchLink fieldCode="PM" term="%2215969739%22">15969739)</searchLink><br />Mol Phylogenet Evol. 2005 Dec;37(3):644-60. (PMID: <searchLink fieldCode="PM" term="%2216055353%22">16055353)</searchLink><br />J Exp Bot. 2024 Jun 7;75(11):3431-3451. (PMID: <searchLink fieldCode="PM" term="%2238520311%22">38520311)</searchLink><br />Pharmacol Res. 2006 Jan;53(1):80-7. (PMID: <searchLink fieldCode="PM" term="%2216253514%22">16253514)</searchLink><br />Nat Prod Res. 2017 Feb;31(3):299-307. (PMID: <searchLink fieldCode="PM" term="%2227681295%22">27681295)</searchLink><br />Sci Rep. 2017 Nov 22;7(1):16074. (PMID: <searchLink fieldCode="PM" term="%2229167468%22">29167468)</searchLink><br />Mol Phylogenet Evol. 2009 Aug;52(2):538-43. (PMID: <searchLink fieldCode="PM" term="%2219364536%22">19364536)</searchLink><br />Theor Appl Genet. 2019 Mar;132(3):627-645. (PMID: <searchLink fieldCode="PM" term="%2230824972%22">30824972)</searchLink><br />Planta Med. 1999 Dec;65(8):735-9. (PMID: <searchLink fieldCode="PM" term="%2210630116%22">10630116)</searchLink><br />Plant Physiol. 2003 Apr;131(4):1868-76. (PMID: <searchLink fieldCode="PM" term="%2212692346%22">12692346)</searchLink><br />J Chromatogr. 1963 Aug;11:463-71. (PMID: <searchLink fieldCode="PM" term="%2214062605%22">14062605)</searchLink><br />Plant Mol Biol. 2014 Sep;86(1-2):171-83. (PMID: <searchLink fieldCode="PM" term="%2225033935%22">25033935)</searchLink><br />Genome Res. 2003 Nov;13(11):2498-504. (PMID: <searchLink fieldCode="PM" term="%2214597658%22">14597658)</searchLink><br />PLoS One. 2015 May 28;10(5):e0124106. (PMID: <searchLink fieldCode="PM" term="%2226020634%22">26020634)</searchLink><br />Phytochemistry. 2009 Jun;70(9):1146-1160. (PMID: <searchLink fieldCode="PM" term="%2219660770%22">19660770)</searchLink><br />Nat Protoc. 2013 Aug;8(8):1494-512. (PMID: <searchLink fieldCode="PM" term="%2223845962%22">23845962)</searchLink><br />Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: <searchLink fieldCode="PM" term="%2219505943%22">19505943)</searchLink><br />Genes (Basel). 2022 Nov 19;13(11):. (PMID: <searchLink fieldCode="PM" term="%2236421835%22">36421835)</searchLink><br />J Biol Chem. 2009 Sep 25;284(39):26510-8. (PMID: <searchLink fieldCode="PM" term="%2219635799%22">19635799)</searchLink><br />Plant J. 2015 Dec;84(6):1100-13. (PMID: <searchLink fieldCode="PM" term="%2226506081%22">26506081)</searchLink><br />Anal Bioanal Chem. 2016 May;408(12):3295-307. (PMID: <searchLink fieldCode="PM" term="%2226922339%22">26922339)</searchLink><br />Genetica. 2010 Feb;138(2):241-9. (PMID: <searchLink fieldCode="PM" term="%2219844793%22">19844793)</searchLink>
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  Data: <i>Keywords: </i>GC–MS; Gene expression; ISSR; Ladano; Molecular markers
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    Identifiers:
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        Value: 10.1007/s00425-026-05072-1
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Genotype
        Type: general
      – SubjectFull: Gene Expression Profiling
        Type: general
      – SubjectFull: Genetic Variation
        Type: general
      – SubjectFull: Transcriptome
        Type: general
      – SubjectFull: Gene Expression Regulation, Plant
        Type: general
      – SubjectFull: Greece
        Type: general
      – SubjectFull: Diterpenes metabolism
        Type: general
      – SubjectFull: Diterpenes chemistry
        Type: general
      – SubjectFull: Cistus genetics
        Type: general
      – SubjectFull: Cistus metabolism
        Type: general
      – SubjectFull: Cistus chemistry
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    Titles:
      – TitleFull: Harnessing genetic, chemical, and transcriptomic analyses guided the selection of Cistus creticus subsp. creticus genotypes rich in labdane-type diterpenes.
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            NameFull: Kostas S
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            NameFull: Ntoanidou S
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            NameFull: Kotoula AA
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            NameFull: Hatziloukas E
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          Dates:
            – D: 15
              M: 07
              Text: 2026 Jul 15
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1432-2048
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              Value: 264
            – Type: issue
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            – TitleFull: Planta
              Type: main
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