Academic Journal
Impact of ultra-low tidal volume ventilation on 1-year functional outcome in COVID-19 ARDS patients. A long-term follow-up analysis of a randomized controlled trial.
| Τίτλος: | Impact of ultra-low tidal volume ventilation on 1-year functional outcome in COVID-19 ARDS patients. A long-term follow-up analysis of a randomized controlled trial. |
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| Συγγραφείς: | Richard JC; Medical Intensive Care Unit, Hospices Civils de Lyon, Croix-Rousse Hospital, Lyon, France. j-christophe.richard@chu-lyon.fr.; Université de Lyon, Université Lyon 1, Lyon, France. j-christophe.richard@chu-lyon.fr.; CREATIS INSERM, Villeurbanne, 1044 CNRS 5220, France. j-christophe.richard@chu-lyon.fr., Chorfa F; Service de Biostatistique et Bioinformatique, Hospices Civils de Lyon, Pôle Santé Publique, Lyon, France., Terzi N; Service de Médecine Intensive Réanimation, CHU Grenoble Alpes, La Tronche, France.; Université de Grenoble-Alpes, Grenoble, France.; INSERM U1042, Grenoble, France., Yonis H; Medical Intensive Care Unit, Hospices Civils de Lyon, Croix-Rousse Hospital, Lyon, France., Wallet F; Medical-Surgical Intensive Care Unit, Hospices Civils de Lyon, Lyon-Sud Hospital, Pierre-Bénite, France.; Research on Healthcare Performance RESHAPE, INSERM U1290, Université Claude Bernard Lyon 1, Lyon, France., Dupuis C; Medical Intensive Care Unit, CHU Gabriel Montpied, Clermont- Ferrand, France., Argaud L; Medical Intensive Care Unit, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France., Delannoy B; Medical-Surgical Intensive Care Unit, Clinique de la Sauvegarde, Lyon, France., Thiery G; Research on Healthcare Performance RESHAPE, INSERM U1290, Université Claude Bernard Lyon 1, Lyon, France.; Medical Intensive Care Unit, CHU Saint-Etienne, Hôpital Nord, Saint- Priest-En-Jarez, France., Bourdin G; Medical-Surgical Intensive Care Unit, Centre Hospitalier Saint Joseph-Saint Luc, Lyon, France., Rimmele T; Surgical Intensive Care Unit, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France., Muller M; Medical-Surgical Intensive Care Unit, Centre Hospitalier Annecy Genevois, Pringy, France., Sigaud F; Service de Médecine Intensive Réanimation, CHU Grenoble Alpes, La Tronche, France., Rigault G; Service de Médecine Intensive Réanimation, CHU Grenoble Alpes, La Tronche, France.; Université de Grenoble-Alpes, Grenoble, France., Joffredo E; Medical-Surgical Intensive Care Unit, Hospices Civils de Lyon, Lyon-Sud Hospital, Pierre-Bénite, France., Mezidi M; Medical Intensive Care Unit, Hospices Civils de Lyon, Croix-Rousse Hospital, Lyon, France., Souweine B; Medical Intensive Care Unit, CHU Gabriel Montpied, Clermont- Ferrand, France., Baboi L; Medical Intensive Care Unit, Hospices Civils de Lyon, Croix-Rousse Hospital, Lyon, France., Serrier H; Research on Healthcare Performance RESHAPE, INSERM U1290, Université Claude Bernard Lyon 1, Lyon, France.; Public Health Center, Hospices Civils de Lyon, Health Economic Evaluation Service, Lyon, France., Rabilloud M; Université de Lyon, Université Lyon 1, Lyon, France.; Service de Biostatistique et Bioinformatique, Hospices Civils de Lyon, Pôle Santé Publique, Lyon, France.; Laboratoire de Biométrie et Biologie Évolutive, CNRS, UMR 5558, Équipe Biostatistique-Santé, Villeurbanne, France., Bitker L; Medical Intensive Care Unit, Hospices Civils de Lyon, Croix-Rousse Hospital, Lyon, France.; Université de Lyon, Université Lyon 1, Lyon, France.; CREATIS INSERM, Villeurbanne, 1044 CNRS 5220, France. |
| Πηγή: | Critical care (London, England) [Crit Care] 2026 Jul 14; Vol. 30 (1). Date of Electronic Publication: 2026 Jul 14. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial; Multicenter Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE |
| Imprint Name(s): | Publication: London, UK : BioMed Central Ltd Original Publication: London : Current Science Ltd, c1997- |
| Ιατρικοί όροι (MeSH): | Tidal Volume*/physiology , COVID-19*/therapy , COVID-19*/complications , Respiratory Distress Syndrome*/therapy , Respiration, Artificial*/methods, Humans ; Female ; Male ; Follow-Up Studies ; Middle Aged ; Aged ; France ; Treatment Outcome ; Intensive Care Units |
| Περίληψη: | Background: Ultra-low tidal volume ventilation (ULTV) aims to minimize ventilator-induced lung injury in acute respiratory distress syndrome (ARDS), but is associated with an increase in arterial carbon dioxide (PaCO Methods: VT4COVID was an open-label multicenter randomized controlled superiority trial performed in ten French intensive care units. Eligible patients were COVID-19 ARDS patients with arterial oxygen pressure (PaO Results: Two hundred and fifteen patients were randomized to ULTV (n = 106) or LTV (n = 109) between April,2020 and April,2021. Seven patients were lost to follow-up and 34 surviving patients had missing data for at least one score. Mortality at day-365 was not significantly different between ULTV and LTV arms (47/102 [46%] vs. 44/106 [42%], hazard ratio 1.19 (95% confidence interval (CI Conclusions: ULTV is associated with a small but significant decrease in cognitive status at day-365 possibly related to exposure to higher PaCO Trial Registration: The trial was prospectively registered with ClinicalTrials.gov (NCT04349618) on April 16, 2020. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the amended declaration of Helsinki, and was approved by a research ethics committee (CPP-IDF-VII) on April 14, 2020, under the reference IDCRB-2020-A00869-30. We obtained written informed consent from all patients and/or representatives. Consent for publication: Not applicable. Competing interests: JC Richard received a grant from Hospices Civils de Lyon to conduct the present study, congress attendance fees by Pfizer and Gilead, scientific consultancy fees provided by Gilead unrelated to the submitted work, and lecture fees provided by Astra Zeneca and AMGEN unrelated to the submitted work. F Chorfa did not report any conflict of interest N. Terzi received lecture fees from Pfizer and Fisher & Peykel Healthcare unrelated to the submitted work, and congress attendance fees by Gilead H Yonis received a grant from the French Ministry of Health to conduct the study. F Wallet did not report any conflict of interest C Dupuis did not report any conflict of interest L Argaud did not report any conflict of interest B Delannoy did not report any conflict of interest G Thiery did not report any conflict of interest G Bourdin did not report any conflict of interest T Rimmelé did not report any conflict of interest M Muller did not report any conflict of interest F Sigaud did not report any conflict of interest G Rigaud reported congress attendance fees covered by Pfizer E Joffredo did not report any conflict of interest M Mezidi reported congress attendance fees covered by Pfizer B Souweine did not report any conflict of interest L Baboi did not report any conflict of interest H Serrier did not report any conflict of interest M Rabilloud has no conflict of interest L Bitker received a research grant from Hospices Civils de Lyon to conduct another study, received lecture fees from Viatris, and congress attendance fees from Pfizer. Prior presentation of study results: Part of this work has been presented as an abstract in the following congresses: European society of Intensive Care Medicine 2025 (Munich) Société de Réanimation de Langue Française 2025 (Paris) |
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| Contributed Indexing: | Keywords: ARDS; COVID-19; Cognitive function; Hypercapnia; Protective ventilation. |
| Molecular Sequence: | ClinicalTrials.gov NCT04349618 |
| Entry Date(s): | Date Created: 20260715 Date Completed: 20261008 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| PubMed Central ID: | PMC13647660 |
| DOI: | 10.1186/s13054-026-06195-3 |
| PMID: | 42449426 |
| Βάση Δεδομένων: | MEDLINE |
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