Academic Journal
A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions.
| Τίτλος: | A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions. |
|---|---|
| Συγγραφείς: | Yun Z; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China.; School of Computer Science and Engineering, Southeast University, Nanjing, China.; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Fudan University, Shanghai, China., Ye W; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China.; School of Biological Science & Medical Engineering, Southeast University, Nanjing, China., Ji N; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.; Beijing Key Laboratory of Brain Tumor, Beijing, China., Wang Y; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; Chinese Institutes for Medical Research, Capital Medical University, Beijing, China., Rong J; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China., Li T; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.; Beijing Key Laboratory of Brain Tumor, Beijing, China., Li Y; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China.; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Fudan University, Shanghai, China.; School of Biological Science & Medical Engineering, Southeast University, Nanjing, China., Shen Q; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China.; School of Computer Science and Engineering, Southeast University, Nanjing, China., Wang R; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China., Zhang H; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China., Xu H; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China., Mo N; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China., Song B; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China., Chen X; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China., Wang Y; Pediatric Epilepsy Center, Peking University First Hospital, Beijing, China., Mai Y; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.; China National Clinical Research Center for Neurological Diseases, Beijing, China.; Beijing Key Laboratory of Brain Tumor, Beijing, China., Ding M; School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, China., Ding SL; Allen Institute for Brain Science, Seattle, WA, USA., Liu L; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Southeast University, Nanjing, China. lijuan-liu@seu.edu.cn.; School of Biological Science & Medical Engineering, Southeast University, Nanjing, China. lijuan-liu@seu.edu.cn., Zhang L; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. zhanglw@bjtth.org.; China National Clinical Research Center for Neurological Diseases, Beijing, China. zhanglw@bjtth.org.; Beijing Key Laboratory of Brain Tumor, Beijing, China. zhanglw@bjtth.org.; Chinese Institutes for Medical Research, Capital Medical University, Beijing, China. zhanglw@bjtth.org.; Beijing Neurosurgical Institute, Beijing, China. zhanglw@bjtth.org., Peng H; New Cornerstone Science Laboratory, Institute for Brain and Intelligence, Fudan University, Shanghai, China. h@braintell.org.; Shanghai Academy of Natural Sciences, Fudan University, Shanghai, China. h@braintell.org. |
| Πηγή: | Nature neuroscience [Nat Neurosci] 2026 Sep; Vol. 29 (9), pp. 2296-2310. Date of Electronic Publication: 2026 Jul 14. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2002->: New York, NY : Nature Publishing Group Original Publication: New York, NY : Nature America Inc., c1998- |
| Ιατρικοί όροι (MeSH): | Dendrites*/physiology , Dendrites*/ultrastructure , Cerebral Cortex*/cytology , Cerebral Cortex*/physiology , Neurons*/cytology , Neurons*/physiology, Animals ; Humans ; Mice ; Species Specificity ; Female ; Male |
| Περίληψη: | Cross-species comparisons of neuronal morphology can reveal evolutionary diversification of cortical organization, but they remain limited by scarce human reconstructions, uncertain regional correspondence and scale-dependent morphometrics. Here we introduce a region correspondence framework to compare single-neuron dendritic morphology between mouse and human cortex. Corresponding cortical regions were rigorously defined by integrating anatomical annotations, functional evidence and registration stability and then evaluated using cross-species transcriptomic cell composition profiles. We analyzed dendritic reconstructions of 2,363 human and 16,011 mouse neurons from frontal, parietal and temporal lobes, comparing size-normalized local morphometric features within matched regions. Human cortical neurons showed higher branching frequency and shorter branching intervals, indicating compact local dendritic architecture beyond proportional size enlargement. Local morphology also showed stronger lobe-level separability in humans, associated mainly with spatial dendritic organization, whereas mouse separability reflected branching topology. Additional molecular, physiological, metabolic and geometric analyses showed partial concordance with morphology-based lobe separability, supporting divergent organization of cortical dendrites across species. (© 2026. The Author(s).) |
| Competing Interests: | Competing interests: The authors declare no competing interests. |
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| Entry Date(s): | Date Created: 20260714 Date Completed: 20260902 Latest Revision: 20260904 |
| Update Code: | 20260904 |
| PubMed Central ID: | PMC13533831 |
| DOI: | 10.1038/s41593-026-02376-z |
| PMID: | 42449132 |
| Βάση Δεδομένων: | MEDLINE |
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