Academic Journal
Analysis and Annotation of c-Type Ions in Peptide Mass Spectral Libraries.
| Τίτλος: | Analysis and Annotation of c-Type Ions in Peptide Mass Spectral Libraries. |
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| Συγγραφείς: | Burke MC; Mass Spectrometry Data Center, Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland20899, United States., Yang X; Mass Spectrometry Data Center, Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland20899, United States., Liang Y; Mass Spectrometry Data Center, Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland20899, United States., Neta P; Mass Spectrometry Data Center, Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland20899, United States., Stein SE; Mass Spectrometry Data Center, Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland20899, United States. |
| Πηγή: | Journal of proteome research [J Proteome Res] 2026 Aug 07; Vol. 25 (8), pp. 4315-4321. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, D.C. : American Chemical Society, c2002- |
| Ιατρικοί όροι (MeSH): | Peptides*/chemistry , Peptides*/analysis , Proteomics*/methods , Peptide Library*, Ions/chemistry ; Tandem Mass Spectrometry/methods ; Humans ; Amino Acid Sequence |
| Περίληψη: | The large collection of high-quality mass spectra in the NIST Human HCD Peptide and NIST Tandem Mass Spectral Libraries is used to understand the role of peptide sequence in c-type ion formation in beam-type collision-induced dissociation. Furthermore, results from the analyses were used to inform and apply annotation rules for c-type ions in the updated Human HCD Peptide Mass Spectral Library. As a result, 155,663 c-type ions are now annotated, providing additional peptide sequence information, often where b- and y-type ions may be lacking. Examples shown here highlight the significance of these c-type ions, both in terms of their relative abundance and in resolving peptide-sequence ambiguities. Furthermore, these examples illustrate the value of including c-type ions to improve searching and scoring of peptide spectrum matches. (Not subject to U.S. Copyright. Published 2026 by American Chemical Society.) |
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| Contributed Indexing: | Keywords: Mass Spectral Library; asparagine; cysteine; glutamine; proteomics |
| Substance Nomenclature: | 0 (Ions) 0 (Peptide Library) 0 (Peptides) |
| Entry Date(s): | Date Created: 20260714 Date Completed: 20260807 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13459556 |
| DOI: | 10.1021/acs.jproteome.6c00094 |
| PMID: | 42447324 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1535-3907 |
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| DOI: | 10.1021/acs.jproteome.6c00094 |