Academic Journal
Mechanisms by Which Plant Extracts Ameliorate Bovine Mastitis Through the Regulation of Mitochondrial Function: A Review.
| Τίτλος: | Mechanisms by Which Plant Extracts Ameliorate Bovine Mastitis Through the Regulation of Mitochondrial Function: A Review. |
|---|---|
| Συγγραφείς: | Li Z; Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China., Song J; Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China., Ao C; Key Laboratory of Animal Nutrition and Feed Science, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China., Wang L; Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China., Zhang T; Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China., Zhao Y; Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China., Guo C; Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China., Zhong H; Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China., Liu J; Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China. |
| Πηγή: | Cells [Cells] 2026 Jul 06; Vol. 15 (13). Date of Electronic Publication: 2026 Jul 06. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| Ιατρικοί όροι (MeSH): | Mastitis, Bovine*/drug therapy , Mastitis, Bovine*/pathology , Mastitis, Bovine*/metabolism , Mitochondria*/drug effects , Mitochondria*/metabolism , Plant Extracts*/pharmacology , Plant Extracts*/therapeutic use, Mammary Glands, Animal/drug effects ; Mammary Glands, Animal/pathology ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Animals ; Cattle ; Female |
| Περίληψη: | Mastitis is recognized worldwide as one of the most expensive and common bovine diseases, severely affecting bovine health and milk quality. Mitochondria, known to play important roles in bovine mammary epithelial cells (BMECs), not only provide energy for milk synthesis but also participate in the regulation of the intracellular redox balance, inflammatory reactions, calcium signal transduction, and apoptosis. Mastitis destroys the dynamic balance between the intrinsic repair and damage mechanisms of mitochondria, which leads to mitochondrial dysfunction and aggravation of mammary cell injury or apoptosis. Plant extracts are rich in bioactive substances and are promising antibiotic substitutes for alleviating bovine mastitis. This paper reviews the mechanism through which plant extracts promote mitochondrial repair by interfering with mitophagy, dynamic balance and biogenesis, and alleviate mitochondrial damage by inhibiting mitochondrial ROS, calcium homeostasis imbalance and permeability changes, resulting in the regulation of the mitochondrial function of mammary cells under inflammation and oxidative stress. Elucidation of these mechanisms can provide new strategies for the targeted control of bovine mastitis. |
| Grant Information: | 2024QN03074 the Natural Science Foundation of Inner Mongolia Autonomous Region of China; 2025CXJJM03 Scientific Research Guarantee Fund Project; RO2400002409 Introduced Talent Scientific Research Support Program of Inner Mongolia Autonomous Region; 2026MS1045 Natural Science Foundation of Inner Mongolia Autonomous Region of China; 2023YFDZ0008 Science and Technology Plan Program of Inner Mongolia Autonomous Region |
| Contributed Indexing: | Keywords: mastitis; mitochondrial damage; mitochondrial dysfunction; mitochondrial repair; plant extracts; targeted regulatory mechanism |
| Substance Nomenclature: | 0 (Plant Extracts) 0 (Reactive Oxygen Species) |
| Entry Date(s): | Date Created: 20260713 Date Completed: 20260713 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13359788 |
| DOI: | 10.3390/cells15131222 |
| PMID: | 42439696 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!