Academic Journal
Spatial-Niche Perspective on the Heterogeneity and Functional Reprogramming of Tumor-Associated Macrophages in Digestive System Tumors.
| Τίτλος: | Spatial-Niche Perspective on the Heterogeneity and Functional Reprogramming of Tumor-Associated Macrophages in Digestive System Tumors. |
|---|---|
| Συγγραφείς: | Zhang J; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Huang Y; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Zhang M; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Lou J; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Zhang S; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Zhao S; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Song Z; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Zhang K; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China., Jiang T; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Traditional Chinese Medicine 'Preventing Disease' Wisdom Health Project Research Center of Zhejiang, Hangzhou 310053, China., Zhang G; School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Zhejiang Key Laboratory of Blood-Stasis-Toxin Syndrome, Zhejiang Chinese Medical University, Hangzhou 310053, China.; Traditional Chinese Medicine 'Preventing Disease' Wisdom Health Project Research Center of Zhejiang, Hangzhou 310053, China. |
| Πηγή: | Cells [Cells] 2026 Jul 01; Vol. 15 (13). Date of Electronic Publication: 2026 Jul 01. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI |
| Ιατρικοί όροι (MeSH): | Tumor-Associated Macrophages*/pathology , Tumor-Associated Macrophages*/metabolism , Digestive System Neoplasms*/pathology , Digestive System Neoplasms*/immunology , Digestive System Neoplasms*/metabolism , Tumor Microenvironment* , Cellular Reprogramming*, Humans ; Animals ; Metabolic Reprogramming |
| Περίληψη: | Tumor-associated macrophages (TAMs) are among the most important myeloid cell populations in the tumor microenvironment of digestive system tumors and are characterized by marked plasticity, heterogeneity, and context dependence. This review focuses on gastric, colorectal, liver, and pancreatic cancers as representative digestive system solid tumors in which TAM spatial organization has been increasingly characterized by single-cell and spatial omics studies. Traditional M1/M2 polarization or fixed subtype-based classification is insufficient to capture the continuous state transitions of TAMs across tumor types, disease stages, and tissue regions. Recent evidence suggests that TAM heterogeneity reflects dynamic functional states shaped within distinct spatial niches by local oxygen supply, metabolic stress, stromal architecture, vascular status, and interactions with neighboring cells. From a spatial-niche perspective, this review synthesizes current evidence on TAM distribution patterns, phenotypic changes, and functional biases across six recurrent spatial contexts: the hypoxic core, invasive front, fibrotic septa, perivascular regions, tertiary lymphoid structure (TLS)-adjacent regions, and necrotic borders. By linking these niches with cross-niche functional axes and evidence-supported molecular programs, we provide a structured niche-to-function framework for comparing TAM spatial heterogeneity and its major functional dimensions, including metabolic adaptation, tissue remodeling, and immune-inflammatory regulation. This context-sensitive framework may help guide future studies of niche-specific TAM reprogramming and rational combinations with immunotherapy and other treatment strategies. |
| Grant Information: | U23A20499 National Natural Science Foundation of China; 2026C02A1089 People's Government of Zhejiang Province; Transformation Project of the Chunyan Project CY202302 Zhejiang Chinese Medical University |
| Contributed Indexing: | Keywords: digestive system tumors; functional reprogramming; immunotherapy; macrophage heterogeneity; spatial niches; spatial transcriptomics; tumor microenvironment; tumor-associated macrophages |
| Entry Date(s): | Date Created: 20260713 Date Completed: 20260713 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13359434 |
| DOI: | 10.3390/cells15131198 |
| PMID: | 42439673 |
| Βάση Δεδομένων: | MEDLINE |
καταχωρήστε σχόλιο πρώτοι!