Academic Journal
Early clinical outcomes of keratoplasty using donor corneas preserved in sinasol (ZiSol) versus optisol-GS.
| Τίτλος: | Early clinical outcomes of keratoplasty using donor corneas preserved in sinasol (ZiSol) versus optisol-GS. |
|---|---|
| Συγγραφείς: | Hassanpour K; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Babaki M; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Javadi MA; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Kanavi MR; Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. rezaeikanavi@sbmu.ac.ir. |
| Πηγή: | Cell and tissue banking [Cell Tissue Bank] 2026 Jul 12; Vol. 27 (3). Date of Electronic Publication: 2026 Jul 12. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 100965121 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6814 (Electronic) Linking ISSN: 13899333 NLM ISO Abbreviation: Cell Tissue Bank Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Dordrecht, the Netherlands : Kluwer Academic Publishers, c2000- |
| Ιατρικοί όροι (MeSH): | Keratoplasty, Penetrating*/methods , Cornea*/drug effects , Cornea*/surgery , Chondroitin Sulfates*/pharmacology , Dextrans*/pharmacology , Gentamicins*/pharmacology , Organ Preservation Solutions*/pharmacology , Descemet Stripping Endothelial Keratoplasty*/methods , Complex Mixtures*, Humans ; Female ; Male ; Treatment Outcome ; Tissue Donors ; Aged ; Middle Aged ; Prospective Studies ; Visual Acuity ; Double-Blind Method |
| Περίληψη: | To compare early postoperative outcomes of penetrating keratoplasty (PKP) and Descemet stripping automated endothelial keratoplasty (DSAEK) using donor corneas preserved in ZiSol (formerly Sinasol) versus Optisol-GS. Prospective, double-masked, randomized clinical trial. Ninety-seven eligible eyes undergoing PKP or DSAEK were randomized to receive corneas preserved in ZiSol or Optisol-GS at 4 °C. Preoperative assessments included uncorrected distance visual acuity (UDVA) and corneal edema grading. Postoperative visits at 1 week, 1, 3, and 6 months assessed UDVA, corrected distance visual acuity (CDVA), corneal edema grading, re-epithelialization, microbial keratitis, suture-related complications, and graft attachment (for DSAEK). The PKP cohort comprised 32 ZiSol and 20 Optisol-GS cases; the DSAEK cohort included 13 ZiSol and 23 Optisol-GS cases. At 6 months, mean CDVA was 0.52 ± 0.28 LogMAR (ZiSol) versus 0.41 ± 0.13 LogMAR (Optisol-GS) after PKP (P = 0.132) and 0.47 ± 0.26 versus 0.63 ± 0.40 LogMAR after DSAEK (P = 0.272). Final graft clarity was achieved in 93.3% (ZiSol) and 95.3% (Optisol-GS) of recipients. Complete re-epithelialization by day 7 occurred in 96.9% versus 100% of PKP cases (P > 0.999). Microbial keratitis occurred in 6.3% (ZiSol) and 0% (Optisol-GS) after PKP (P = 0.517). Complete graft attachment after DSAEK occurred in 100% (ZiSol) versus 87% (Optisol-GS) (P = 0.288). Early postoperative outcomes of PKP and DSAEK using ZiSol-preserved donor corneas were statistically comparable to those with Optisol-GS. ZiSol appears to be a safe, effective, and locally accessible alternative for mid-term hypothermic storage in resource-limited settings. (© 2026. The Author(s), under exclusive licence to Springer Nature B.V.) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Corneal preservation; Endothelial keratoplasty; Keratoplasty; Optisol-GS; Sinasol; ZiSol |
| Substance Nomenclature: | 97794-22-4 (Optisol) 9007-28-7 (Chondroitin Sulfates) 0 (Dextrans) 0 (Gentamicins) 0 (Organ Preservation Solutions) 0 (Complex Mixtures) |
| Entry Date(s): | Date Created: 20260711 Date Completed: 20260711 Latest Revision: 20260909 |
| Update Code: | 20260909 |
| DOI: | 10.1007/s10561-026-10239-x |
| PMID: | 42436351 |
| Βάση Δεδομένων: | MEDLINE |
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