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Early clinical outcomes of keratoplasty using donor corneas preserved in sinasol (ZiSol) versus optisol-GS.

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Τίτλος: Early clinical outcomes of keratoplasty using donor corneas preserved in sinasol (ZiSol) versus optisol-GS.
Συγγραφείς: Hassanpour K; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Babaki M; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Javadi MA; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Kanavi MR; Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. rezaeikanavi@sbmu.ac.ir.
Πηγή: Cell and tissue banking [Cell Tissue Bank] 2026 Jul 12; Vol. 27 (3). Date of Electronic Publication: 2026 Jul 12.
Τύπος έκδοσης: Journal Article; Randomized Controlled Trial; Comparative Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 100965121 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6814 (Electronic) Linking ISSN: 13899333 NLM ISO Abbreviation: Cell Tissue Bank Subsets: MEDLINE
Imprint Name(s): Original Publication: Dordrecht, the Netherlands : Kluwer Academic Publishers, c2000-
Ιατρικοί όροι (MeSH): Keratoplasty, Penetrating*/methods , Cornea*/drug effects , Cornea*/surgery , Chondroitin Sulfates*/pharmacology , Dextrans*/pharmacology , Gentamicins*/pharmacology , Organ Preservation Solutions*/pharmacology , Descemet Stripping Endothelial Keratoplasty*/methods , Complex Mixtures*, Humans ; Female ; Male ; Treatment Outcome ; Tissue Donors ; Aged ; Middle Aged ; Prospective Studies ; Visual Acuity ; Double-Blind Method
Περίληψη: To compare early postoperative outcomes of penetrating keratoplasty (PKP) and Descemet stripping automated endothelial keratoplasty (DSAEK) using donor corneas preserved in ZiSol (formerly Sinasol) versus Optisol-GS. Prospective, double-masked, randomized clinical trial. Ninety-seven eligible eyes undergoing PKP or DSAEK were randomized to receive corneas preserved in ZiSol or Optisol-GS at 4 °C. Preoperative assessments included uncorrected distance visual acuity (UDVA) and corneal edema grading. Postoperative visits at 1 week, 1, 3, and 6 months assessed UDVA, corrected distance visual acuity (CDVA), corneal edema grading, re-epithelialization, microbial keratitis, suture-related complications, and graft attachment (for DSAEK). The PKP cohort comprised 32 ZiSol and 20 Optisol-GS cases; the DSAEK cohort included 13 ZiSol and 23 Optisol-GS cases. At 6 months, mean CDVA was 0.52 ± 0.28 LogMAR (ZiSol) versus 0.41 ± 0.13 LogMAR (Optisol-GS) after PKP (P = 0.132) and 0.47 ± 0.26 versus 0.63 ± 0.40 LogMAR after DSAEK (P = 0.272). Final graft clarity was achieved in 93.3% (ZiSol) and 95.3% (Optisol-GS) of recipients. Complete re-epithelialization by day 7 occurred in 96.9% versus 100% of PKP cases (P > 0.999). Microbial keratitis occurred in 6.3% (ZiSol) and 0% (Optisol-GS) after PKP (P = 0.517). Complete graft attachment after DSAEK occurred in 100% (ZiSol) versus 87% (Optisol-GS) (P = 0.288). Early postoperative outcomes of PKP and DSAEK using ZiSol-preserved donor corneas were statistically comparable to those with Optisol-GS. ZiSol appears to be a safe, effective, and locally accessible alternative for mid-term hypothermic storage in resource-limited settings.
(© 2026. The Author(s), under exclusive licence to Springer Nature B.V.)
Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests.
References: Armitage WJ (2011) Preservation of human cornea. Transfus Med Hemother 38(2):143–147. (PMID: 10.1159/000326632215667143088736)
Basak S, Prajna NV (2016) A prospective, in vitro, randomized study to compare two media for donor corneal storage. Cornea 35(9):1151–1155. (PMID: 10.1097/ICO.000000000000091227310880)
Bourne WM, Nelson LR, Maguire LJ, Baratz KH, Hodge DO (2001) Comparison of Chen medium and Optisol-GS for human corneal preservation at 4 degrees C: results of transplantation. Cornea 20(7):683–686. (PMID: 10.1097/00003226-200110000-0000311588417)
Christo CG, van Rooij J, Geerards AJ, Remeijer L, Beekhuis WH (2001) Suture-related complications following keratoplasty: a 5-year retrospective study. Cornea 20(8):816–819. (PMID: 10.1097/00003226-200111000-0000811685058)
Fasolo A, Capuzzo C, Fornea M, Frigo AC, Monterosso C, Zampini A, Avarello A, Galan A, Sbordone S, Ragucci AE, Gorla C, Grigoletto F, Ponzin D (2012) Health status and patient satisfaction after corneal graft: results from the corneal transplant epidemiological study. J Ophthalmol 2012:230641. (PMID: 10.1155/2012/230641226197013348637)
Fong LP, Ormerod LD, Kenyon KR, Foster CS (1988) Microbial keratitis complicating penetrating keratoplasty. Ophthalmology 95(9):1269–1275. (PMID: 10.1016/S0161-6420(88)33036-83062538)
Javadi MA, Kanavi MR, Safi S (2020) A 27-year report from the Central Eye Bank of Iran. J Ophthalmic vis Res 15(2):149–159. (PMID: 10.18502/jovr.v15i2.6731)
Javadi MA, Rezaeian Akbarzadeh A, Chamani T, Rezaei Kanavi M (2021) Sinasol versus Optisol-GS for cold preservation of human cornea: a prospective ex vivo and clinical study. Cell Tissue Bank 22(4):563–574. (PMID: 10.1007/s10561-021-09930-y33937957)
Javadi F, Kheiri B, Akbarzadeh AR, Kanavi MR (2023) Thickness profile of donated corneas preserved in Optisol-GS versus Sinasol: an ex-vivo study. J Ophthalmic vis Res 18:379–385. (PMID: 10.18502/jovr.v18i4.145463825023510794802)
Jeng BH (2006) Preserving the cornea: corneal storage media. Curr Opin Ophthalmol 17(4):332–337. (PMID: 10.1097/01.icu.0000233950.63853.8816900023)
Kaufman HE, Beuerman RW, Steinemann TL, Thompson HW, Varnell ED (1991) Optisol corneal storage medium. Arch Ophthalmol 109(6):864–868. (PMID: 10.1001/archopht.1991.010800601280401710444)
Lee WB, Jacobs DS, Musch DC, Kaufman SC, Reinhart WJ, Shtein RM (2009) Descemet’s stripping endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology. Ophthalmology 116(9):1818–1830. (PMID: 10.1016/j.ophtha.2009.06.02119643492)
Lemaitre D, Tourabaly M, Borderie V, Dechartres A (2023) Long-term outcomes after lamellar endothelial keratoplasty compared with penetrating keratoplasty for corneal endothelial dysfunction: a systematic review. Cornea 42(7):917–928. (PMID: 10.1097/ICO.000000000000324037185592)
Lindstrom RL, Kaufman HE, Skelnik DL, Laing RA, Lass JH, Musch DC, Trousdale MD, Reinhart WJ, Burris TE, Sugar A et al (1992) Optisol corneal storage medium. Am J Ophthalmol 114:345–356. (PMID: 10.1016/S0002-9394(14)71803-31524127)
McCarey BE, Kaufman HE (1976) Improved corneal storage for penetrating keratoplasties in humans. Ann Ophthalmol 8:1488–1492. (PMID: 797295)
Melles GR, Binder PS (1990) A comparison of wound healing in sutured and unsutured corneal wounds. Arch Ophthalmol 108(10):1460–1469. (PMID: 10.1001/archopht.1990.010701201080392222279)
Naor J, Slomovic AR, Chipman M, Rootman DS (2002) A randomized, double-masked clinical trial of Optisol-GS vs Chen medium for human corneal storage. Arch Ophthalmol 120(10):1280–1285. (PMID: 10.1001/archopht.120.10.128012365905)
Pan Q, Li X, Gu Y (2012) Indications and outcomes of penetrating keratoplasty in a tertiary hospital in the developing world. Clin Exp Ophthalmol 40(3):232–238. (PMID: 10.1111/j.1442-9071.2011.02598.x21575124)
Price MO, Knight OJ, Benetz BA, Debanne SM, Verdier DD, Rosenwasser GO, Rosenwasser M, Price FW Jr, Lass JH (2015) Randomized, prospective, single-masked clinical trial of endothelial keratoplasty performance with two donor cornea 4°C storage solutions and associated chambers. Cornea 34(3):253–256. (PMID: 10.1097/ICO.000000000000035425625366)
Sharma N, Shaikh F, Nagpal R, Manumuraleekrishna MPK, Agarwal T, Sinha R, Satpathy G, Velpandian T, Titiyal JS (2021) Evaluation of various preservation media for storage of donor corneas. Indian J Ophthalmol 69(9):2452–2456. (PMID: 10.4103/ijo.IJO_258_21344272438544086)
Singh R, Gupta N, Vanathi M, Tandon R (2019) Corneal transplantation in the modern era. Indian J Med Res 150(1):7–22. (PMID: 10.4103/ijmr.IJMR_141_19315716256798607)
Wagoner MD, Gonnah e-S (2005) Corneal graft survival after prolonged storage in Optisol-GS. Cornea 24(8):976–979. (PMID: 10.1097/01.ico.0000159731.52801.b616227845)
Contributed Indexing: Keywords: Corneal preservation; Endothelial keratoplasty; Keratoplasty; Optisol-GS; Sinasol; ZiSol
Substance Nomenclature: 97794-22-4 (Optisol)
9007-28-7 (Chondroitin Sulfates)
0 (Dextrans)
0 (Gentamicins)
0 (Organ Preservation Solutions)
0 (Complex Mixtures)
Entry Date(s): Date Created: 20260711 Date Completed: 20260711 Latest Revision: 20260909
Update Code: 20260909
DOI: 10.1007/s10561-026-10239-x
PMID: 42436351
Βάση Δεδομένων: MEDLINE
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  Data: Early clinical outcomes of keratoplasty using donor corneas preserved in sinasol (ZiSol) versus optisol-GS.
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  Data: <searchLink fieldCode="AU" term="%22Hassanpour+K%22">Hassanpour K</searchLink>; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Babaki+M%22">Babaki M</searchLink>; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Javadi+MA%22">Javadi MA</searchLink>; Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.<br /><searchLink fieldCode="AU" term="%22Kanavi+MR%22">Kanavi MR</searchLink>; Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran. rezaeikanavi@sbmu.ac.ir.
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  Data: Journal Article; Randomized Controlled Trial; Comparative Study
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  Data: <i>Original Publication</i>: Dordrecht, the Netherlands : Kluwer Academic Publishers, c2000-
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  Data: <searchLink fieldCode="MM" term="%22Keratoplasty%2C+Penetrating%22">Keratoplasty, Penetrating*</searchLink>/<searchLink fieldCode="MM" term="%22Keratoplasty%2C+Penetrating+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Cornea%22">Cornea*</searchLink>/<searchLink fieldCode="MM" term="%22Cornea+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Cornea%22">Cornea*</searchLink>/<searchLink fieldCode="MM" term="%22Cornea+surgery%22">surgery</searchLink> <br /><searchLink fieldCode="MM" term="%22Chondroitin+Sulfates%22">Chondroitin Sulfates*</searchLink>/<searchLink fieldCode="MM" term="%22Chondroitin+Sulfates+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Dextrans%22">Dextrans*</searchLink>/<searchLink fieldCode="MM" term="%22Dextrans+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Gentamicins%22">Gentamicins*</searchLink>/<searchLink fieldCode="MM" term="%22Gentamicins+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Organ+Preservation+Solutions%22">Organ Preservation Solutions*</searchLink>/<searchLink fieldCode="MM" term="%22Organ+Preservation+Solutions+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Descemet+Stripping+Endothelial+Keratoplasty%22">Descemet Stripping Endothelial Keratoplasty*</searchLink>/<searchLink fieldCode="MM" term="%22Descemet+Stripping+Endothelial+Keratoplasty+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Complex+Mixtures%22">Complex Mixtures*</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Treatment+Outcome%22">Treatment Outcome</searchLink> ; <searchLink fieldCode="MH" term="%22Tissue+Donors%22">Tissue Donors</searchLink> ; <searchLink fieldCode="MH" term="%22Aged%22">Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Middle+Aged%22">Middle Aged</searchLink> ; <searchLink fieldCode="MH" term="%22Prospective+Studies%22">Prospective Studies</searchLink> ; <searchLink fieldCode="MH" term="%22Visual+Acuity%22">Visual Acuity</searchLink> ; <searchLink fieldCode="MH" term="%22Double-Blind+Method%22">Double-Blind Method</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: To compare early postoperative outcomes of penetrating keratoplasty (PKP) and Descemet stripping automated endothelial keratoplasty (DSAEK) using donor corneas preserved in ZiSol (formerly Sinasol) versus Optisol-GS. Prospective, double-masked, randomized clinical trial. Ninety-seven eligible eyes undergoing PKP or DSAEK were randomized to receive corneas preserved in ZiSol or Optisol-GS at 4 °C. Preoperative assessments included uncorrected distance visual acuity (UDVA) and corneal edema grading. Postoperative visits at 1 week, 1, 3, and 6 months assessed UDVA, corrected distance visual acuity (CDVA), corneal edema grading, re-epithelialization, microbial keratitis, suture-related complications, and graft attachment (for DSAEK). The PKP cohort comprised 32 ZiSol and 20 Optisol-GS cases; the DSAEK cohort included 13 ZiSol and 23 Optisol-GS cases. At 6 months, mean CDVA was 0.52 ± 0.28 LogMAR (ZiSol) versus 0.41 ± 0.13 LogMAR (Optisol-GS) after PKP (P = 0.132) and 0.47 ± 0.26 versus 0.63 ± 0.40 LogMAR after DSAEK (P = 0.272). Final graft clarity was achieved in 93.3% (ZiSol) and 95.3% (Optisol-GS) of recipients. Complete re-epithelialization by day 7 occurred in 96.9% versus 100% of PKP cases (P > 0.999). Microbial keratitis occurred in 6.3% (ZiSol) and 0% (Optisol-GS) after PKP (P = 0.517). Complete graft attachment after DSAEK occurred in 100% (ZiSol) versus 87% (Optisol-GS) (P = 0.288). Early postoperative outcomes of PKP and DSAEK using ZiSol-preserved donor corneas were statistically comparable to those with Optisol-GS. ZiSol appears to be a safe, effective, and locally accessible alternative for mid-term hypothermic storage in resource-limited settings.<br /> (© 2026. The Author(s), under exclusive licence to Springer Nature B.V.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Conflict of interest: The authors declare no competing interests.
– Name: Ref
  Label: References
  Group: RefInfo
  Data: Armitage WJ (2011) Preservation of human cornea. Transfus Med Hemother 38(2):143–147. (PMID: <searchLink fieldCode="PM" term="%2210%2E1159%2F000326632215667143088736%22">10.1159/000326632215667143088736)</searchLink><br />Basak S, Prajna NV (2016) A prospective, in vitro, randomized study to compare two media for donor corneal storage. Cornea 35(9):1151–1155. (PMID: <searchLink fieldCode="PM" term="%2210%2E1097%2FICO%2E000000000000091227310880%22">10.1097/ICO.000000000000091227310880)</searchLink><br />Bourne WM, Nelson LR, Maguire LJ, Baratz KH, Hodge DO (2001) Comparison of Chen medium and Optisol-GS for human corneal preservation at 4 degrees C: results of transplantation. Cornea 20(7):683–686. (PMID: <searchLink fieldCode="PM" term="%2210%2E1097%2F00003226-200110000-0000311588417%22">10.1097/00003226-200110000-0000311588417)</searchLink><br />Christo CG, van Rooij J, Geerards AJ, Remeijer L, Beekhuis WH (2001) Suture-related complications following keratoplasty: a 5-year retrospective study. Cornea 20(8):816–819. (PMID: <searchLink fieldCode="PM" term="%2210%2E1097%2F00003226-200111000-0000811685058%22">10.1097/00003226-200111000-0000811685058)</searchLink><br />Fasolo A, Capuzzo C, Fornea M, Frigo AC, Monterosso C, Zampini A, Avarello A, Galan A, Sbordone S, Ragucci AE, Gorla C, Grigoletto F, Ponzin D (2012) Health status and patient satisfaction after corneal graft: results from the corneal transplant epidemiological study. J Ophthalmol 2012:230641. (PMID: <searchLink fieldCode="PM" term="%2210%2E1155%2F2012%2F230641226197013348637%22">10.1155/2012/230641226197013348637)</searchLink><br />Fong LP, Ormerod LD, Kenyon KR, Foster CS (1988) Microbial keratitis complicating penetrating keratoplasty. Ophthalmology 95(9):1269–1275. (PMID: <searchLink fieldCode="PM" term="%2210%2E1016%2FS0161-6420%2888%2933036-83062538%22">10.1016/S0161-6420(88)33036-83062538)</searchLink><br />Javadi MA, Kanavi MR, Safi S (2020) A 27-year report from the Central Eye Bank of Iran. J Ophthalmic vis Res 15(2):149–159. (PMID: <searchLink fieldCode="PM" term="%2210%2E18502%2Fjovr%2Ev15i2%2E6731%22">10.18502/jovr.v15i2.6731)</searchLink><br />Javadi MA, Rezaeian Akbarzadeh A, Chamani T, Rezaei Kanavi M (2021) Sinasol versus Optisol-GS for cold preservation of human cornea: a prospective ex vivo and clinical study. Cell Tissue Bank 22(4):563–574. (PMID: <searchLink fieldCode="PM" term="%2210%2E1007%2Fs10561-021-09930-y33937957%22">10.1007/s10561-021-09930-y33937957)</searchLink><br />Javadi F, Kheiri B, Akbarzadeh AR, Kanavi MR (2023) Thickness profile of donated corneas preserved in Optisol-GS versus Sinasol: an ex-vivo study. J Ophthalmic vis Res 18:379–385. (PMID: <searchLink fieldCode="PM" term="%2210%2E18502%2Fjovr%2Ev18i4%2E145463825023510794802%22">10.18502/jovr.v18i4.145463825023510794802)</searchLink><br />Jeng BH (2006) Preserving the cornea: corneal storage media. Curr Opin Ophthalmol 17(4):332–337. (PMID: <searchLink fieldCode="PM" term="%2210%2E1097%2F01%2Eicu%2E0000233950%2E63853%2E8816900023%22">10.1097/01.icu.0000233950.63853.8816900023)</searchLink><br />Kaufman HE, Beuerman RW, Steinemann TL, Thompson HW, Varnell ED (1991) Optisol corneal storage medium. Arch Ophthalmol 109(6):864–868. (PMID: <searchLink fieldCode="PM" term="%2210%2E1001%2Farchopht%2E1991%2E010800601280401710444%22">10.1001/archopht.1991.010800601280401710444)</searchLink><br />Lee WB, Jacobs DS, Musch DC, Kaufman SC, Reinhart WJ, Shtein RM (2009) Descemet’s stripping endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology. Ophthalmology 116(9):1818–1830. (PMID: <searchLink fieldCode="PM" term="%2210%2E1016%2Fj%2Eophtha%2E2009%2E06%2E02119643492%22">10.1016/j.ophtha.2009.06.02119643492)</searchLink><br />Lemaitre D, Tourabaly M, Borderie V, Dechartres A (2023) Long-term outcomes after lamellar endothelial keratoplasty compared with penetrating keratoplasty for corneal endothelial dysfunction: a systematic review. Cornea 42(7):917–928. (PMID: <searchLink fieldCode="PM" term="%2210%2E1097%2FICO%2E000000000000324037185592%22">10.1097/ICO.000000000000324037185592)</searchLink><br />Lindstrom RL, Kaufman HE, Skelnik DL, Laing RA, Lass JH, Musch DC, Trousdale MD, Reinhart WJ, Burris TE, Sugar A et al (1992) Optisol corneal storage medium. Am J Ophthalmol 114:345–356. (PMID: <searchLink fieldCode="PM" term="%2210%2E1016%2FS0002-9394%2814%2971803-31524127%22">10.1016/S0002-9394(14)71803-31524127)</searchLink><br />McCarey BE, Kaufman HE (1976) Improved corneal storage for penetrating keratoplasties in humans. Ann Ophthalmol 8:1488–1492. (PMID: <searchLink fieldCode="PM" term="%22797295%22">797295)</searchLink><br />Melles GR, Binder PS (1990) A comparison of wound healing in sutured and unsutured corneal wounds. Arch Ophthalmol 108(10):1460–1469. (PMID: <searchLink fieldCode="PM" term="%2210%2E1001%2Farchopht%2E1990%2E010701201080392222279%22">10.1001/archopht.1990.010701201080392222279)</searchLink><br />Naor J, Slomovic AR, Chipman M, Rootman DS (2002) A randomized, double-masked clinical trial of Optisol-GS vs Chen medium for human corneal storage. Arch Ophthalmol 120(10):1280–1285. (PMID: <searchLink fieldCode="PM" term="%2210%2E1001%2Farchopht%2E120%2E10%2E128012365905%22">10.1001/archopht.120.10.128012365905)</searchLink><br />Pan Q, Li X, Gu Y (2012) Indications and outcomes of penetrating keratoplasty in a tertiary hospital in the developing world. Clin Exp Ophthalmol 40(3):232–238. (PMID: <searchLink fieldCode="PM" term="%2210%2E1111%2Fj%2E1442-9071%2E2011%2E02598%2Ex21575124%22">10.1111/j.1442-9071.2011.02598.x21575124)</searchLink><br />Price MO, Knight OJ, Benetz BA, Debanne SM, Verdier DD, Rosenwasser GO, Rosenwasser M, Price FW Jr, Lass JH (2015) Randomized, prospective, single-masked clinical trial of endothelial keratoplasty performance with two donor cornea 4°C storage solutions and associated chambers. Cornea 34(3):253–256. (PMID: <searchLink fieldCode="PM" term="%2210%2E1097%2FICO%2E000000000000035425625366%22">10.1097/ICO.000000000000035425625366)</searchLink><br />Sharma N, Shaikh F, Nagpal R, Manumuraleekrishna MPK, Agarwal T, Sinha R, Satpathy G, Velpandian T, Titiyal JS (2021) Evaluation of various preservation media for storage of donor corneas. Indian J Ophthalmol 69(9):2452–2456. (PMID: <searchLink fieldCode="PM" term="%2210%2E4103%2Fijo%2EIJO%26#95%3B258%26#95%3B21344272438544086%22">10.4103/ijo.IJO_258_21344272438544086)</searchLink><br />Singh R, Gupta N, Vanathi M, Tandon R (2019) Corneal transplantation in the modern era. Indian J Med Res 150(1):7–22. (PMID: <searchLink fieldCode="PM" term="%2210%2E4103%2Fijmr%2EIJMR%26#95%3B141%26#95%3B19315716256798607%22">10.4103/ijmr.IJMR_141_19315716256798607)</searchLink><br />Wagoner MD, Gonnah e-S (2005) Corneal graft survival after prolonged storage in Optisol-GS. Cornea 24(8):976–979. (PMID: <searchLink fieldCode="PM" term="%2210%2E1097%2F01%2Eico%2E0000159731%2E52801%2Eb616227845%22">10.1097/01.ico.0000159731.52801.b616227845)</searchLink>
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>Corneal preservation; Endothelial keratoplasty; Keratoplasty; Optisol-GS; Sinasol; ZiSol
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 97794-22-4 (Optisol)<br />9007-28-7 (Chondroitin Sulfates)<br />0 (Dextrans)<br />0 (Gentamicins)<br />0 (Organ Preservation Solutions)<br />0 (Complex Mixtures)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260711 <i>Date Completed: </i>20260711 <i>Latest Revision: </i>20260909
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260909
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1007/s10561-026-10239-x
– Name: AN
  Label: PMID
  Group: ID
  Data: 42436351
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42436351
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10561-026-10239-x
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Treatment Outcome
        Type: general
      – SubjectFull: Tissue Donors
        Type: general
      – SubjectFull: Aged
        Type: general
      – SubjectFull: Middle Aged
        Type: general
      – SubjectFull: Prospective Studies
        Type: general
      – SubjectFull: Visual Acuity
        Type: general
      – SubjectFull: Double-Blind Method
        Type: general
      – SubjectFull: Keratoplasty, Penetrating methods
        Type: general
      – SubjectFull: Cornea drug effects
        Type: general
      – SubjectFull: Cornea surgery
        Type: general
      – SubjectFull: Chondroitin Sulfates pharmacology
        Type: general
      – SubjectFull: Dextrans pharmacology
        Type: general
      – SubjectFull: Gentamicins pharmacology
        Type: general
      – SubjectFull: Organ Preservation Solutions pharmacology
        Type: general
      – SubjectFull: Descemet Stripping Endothelial Keratoplasty methods
        Type: general
      – SubjectFull: Complex Mixtures
        Type: general
    Titles:
      – TitleFull: Early clinical outcomes of keratoplasty using donor corneas preserved in sinasol (ZiSol) versus optisol-GS.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hassanpour K
      – PersonEntity:
          Name:
            NameFull: Babaki M
      – PersonEntity:
          Name:
            NameFull: Javadi MA
      – PersonEntity:
          Name:
            NameFull: Kanavi MR
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 12
              M: 07
              Text: 2026 Jul 12
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1573-6814
          Numbering:
            – Type: volume
              Value: 27
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Cell and tissue banking
              Type: main
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