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Mechanism of seaweed polyphenols interacting with intestinal flora to regulate blood glucose.

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Τίτλος: Mechanism of seaweed polyphenols interacting with intestinal flora to regulate blood glucose.
Συγγραφείς: Du X; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China., Luo X; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China., Chen X; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China., Chen L; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China., Chen Z; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China., Zheng M; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China., Zhu Y; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China., Jiang Z; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China., Li Q; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China., Ni H; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China; Xiamen Ocean Vocational College, Xiamen 361021, Fujian, China., Li Z; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China. Electronic address: lzp2019@jmu.edu.cn.
Πηγή: Food chemistry [Food Chem] 2026 Oct 01; Vol. 525 (Pt 1), pp. 150323. Date of Electronic Publication: 2026 Jul 06.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
Imprint Name(s): Publication: Barking : Elsevier Applied Science Publishers
Original Publication: Barking, Eng., Applied Science Publishers.
Ιατρικοί όροι (MeSH): Polyphenols*/metabolism , Polyphenols*/administration & dosage , Seaweed*/chemistry , Seaweed*/metabolism , Gastrointestinal Microbiome*/drug effects , Blood Glucose*/metabolism , Plant Extracts*/metabolism , Plant Extracts*/administration & dosage , Hypoglycemic Agents*/metabolism , Hypoglycemic Agents*/administration & dosage, Bacteria/metabolism ; Bacteria/classification ; Bacteria/genetics ; Bacteria/isolation & purification ; Sodium-Glucose Transporter 1/metabolism ; Sodium-Glucose Transporter 1/genetics ; Glucose Transporter Type 2/metabolism ; Glucose Transporter Type 2/genetics ; Animals ; Mice ; Humans ; Male
Περίληψη: Seaweed polyphenols possess hypoglycemic biological functions, but the specific mechanisms remain unclear, which limits their further application. In this study, the area under the blood glucose curve (AUC) of the fourth-period Porphyra haitanensis polyphenols extract (FPPE)-fed mice was significantly reduced by 17.12 ± 0.87%. Moreover, FPPE exhibited α-glucosidase inhibitory activity at 64.39 ± 4.05%. In vitro fermentation experiments showed that FPPE modulated the composition of the gut microbiota, thereby enhancing the production of short-chain fatty acids (SCFAs). Analysis of intestinal flora and metabolites in mice revealed that FPPE selectively enriched hypoglycemic-functional bacteria, such as Bacteroides and Alloprevotella. These bacteria feedback-regulated the production of hypoglycemic polyphenolic substances such as isovitexin and isoquercetin, which showed a strong positive correlation. Further mechanistic studies revealed that FPPE's digest could suppress cellular glucose transport by inhibiting the expression of Sodium Glucose Cotransporter 1 (SGLT1) and glucose transporter 2 (GLUT2), thereby reducing blood glucose levels.
(Copyright © 2026 Elsevier Ltd. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Blood glucose regulation; In vitro fermentation; Intestinal flora; Metabolomics; Porphyra haitanensis polyphenols
Substance Nomenclature: 0 (Polyphenols)
0 (Blood Glucose)
0 (Plant Extracts)
0 (Hypoglycemic Agents)
0 (Sodium-Glucose Transporter 1)
0 (Glucose Transporter Type 2)
Entry Date(s): Date Created: 20260711 Date Completed: 20260901 Latest Revision: 20260901
Update Code: 20260901
DOI: 10.1016/j.foodchem.2026.150323
PMID: 42435668
Βάση Δεδομένων: MEDLINE
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  Data: Mechanism of seaweed polyphenols interacting with intestinal flora to regulate blood glucose.
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  Data: <searchLink fieldCode="AU" term="%22Du+X%22">Du X</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Luo+X%22">Luo X</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Zheng+M%22">Zheng M</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Jiang+Z%22">Jiang Z</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Ni+H%22">Ni H</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China; Xiamen Ocean Vocational College, Xiamen 361021, Fujian, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, Fujian, China; Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering, Xiamen 361021, Fujian, China; Research Center of Food Biotechnology of Xiamen City, Xiamen 361021, Fujian, China. Electronic address: lzp2019@jmu.edu.cn.
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  Data: <searchLink fieldCode="MM" term="%22Polyphenols%22">Polyphenols*</searchLink>/<searchLink fieldCode="MM" term="%22Polyphenols+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Polyphenols%22">Polyphenols*</searchLink>/<searchLink fieldCode="MM" term="%22Polyphenols+administration+%26+dosage%22">administration & dosage</searchLink> <br /><searchLink fieldCode="MM" term="%22Seaweed%22">Seaweed*</searchLink>/<searchLink fieldCode="MM" term="%22Seaweed+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Seaweed%22">Seaweed*</searchLink>/<searchLink fieldCode="MM" term="%22Seaweed+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Gastrointestinal+Microbiome%22">Gastrointestinal Microbiome*</searchLink>/<searchLink fieldCode="MM" term="%22Gastrointestinal+Microbiome+drug+effects%22">drug effects</searchLink> <br /><searchLink fieldCode="MM" term="%22Blood+Glucose%22">Blood Glucose*</searchLink>/<searchLink fieldCode="MM" term="%22Blood+Glucose+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Plant+Extracts%22">Plant Extracts*</searchLink>/<searchLink fieldCode="MM" term="%22Plant+Extracts+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Plant+Extracts%22">Plant Extracts*</searchLink>/<searchLink fieldCode="MM" term="%22Plant+Extracts+administration+%26+dosage%22">administration & dosage</searchLink> <br /><searchLink fieldCode="MM" term="%22Hypoglycemic+Agents%22">Hypoglycemic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Hypoglycemic+Agents+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Hypoglycemic+Agents%22">Hypoglycemic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Hypoglycemic+Agents+administration+%26+dosage%22">administration & dosage</searchLink><br /><searchLink fieldCode="MH" term="%22Bacteria%22">Bacteria</searchLink>/<searchLink fieldCode="MH" term="%22Bacteria+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Bacteria%22">Bacteria</searchLink>/<searchLink fieldCode="MH" term="%22Bacteria+classification%22">classification</searchLink> ; <searchLink fieldCode="MH" term="%22Bacteria%22">Bacteria</searchLink>/<searchLink fieldCode="MH" term="%22Bacteria+genetics%22">genetics</searchLink> ; <searchLink fieldCode="MH" term="%22Bacteria%22">Bacteria</searchLink>/<searchLink fieldCode="MH" term="%22Bacteria+isolation+%26+purification%22">isolation & purification</searchLink> ; <searchLink fieldCode="MH" term="%22Sodium-Glucose+Transporter+1%22">Sodium-Glucose Transporter 1</searchLink>/<searchLink fieldCode="MH" term="%22Sodium-Glucose+Transporter+1+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Sodium-Glucose+Transporter+1%22">Sodium-Glucose Transporter 1</searchLink>/<searchLink fieldCode="MH" term="%22Sodium-Glucose+Transporter+1+genetics%22">genetics</searchLink> ; <searchLink fieldCode="MH" term="%22Glucose+Transporter+Type+2%22">Glucose Transporter Type 2</searchLink>/<searchLink fieldCode="MH" term="%22Glucose+Transporter+Type+2+metabolism%22">metabolism</searchLink> ; <searchLink fieldCode="MH" term="%22Glucose+Transporter+Type+2%22">Glucose Transporter Type 2</searchLink>/<searchLink fieldCode="MH" term="%22Glucose+Transporter+Type+2+genetics%22">genetics</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Seaweed polyphenols possess hypoglycemic biological functions, but the specific mechanisms remain unclear, which limits their further application. In this study, the area under the blood glucose curve (AUC) of the fourth-period Porphyra haitanensis polyphenols extract (FPPE)-fed mice was significantly reduced by 17.12 ± 0.87%. Moreover, FPPE exhibited α-glucosidase inhibitory activity at 64.39 ± 4.05%. In vitro fermentation experiments showed that FPPE modulated the composition of the gut microbiota, thereby enhancing the production of short-chain fatty acids (SCFAs). Analysis of intestinal flora and metabolites in mice revealed that FPPE selectively enriched hypoglycemic-functional bacteria, such as Bacteroides and Alloprevotella. These bacteria feedback-regulated the production of hypoglycemic polyphenolic substances such as isovitexin and isoquercetin, which showed a strong positive correlation. Further mechanistic studies revealed that FPPE's digest could suppress cellular glucose transport by inhibiting the expression of Sodium Glucose Cotransporter 1 (SGLT1) and glucose transporter 2 (GLUT2), thereby reducing blood glucose levels.<br /> (Copyright © 2026 Elsevier Ltd. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
– Name: SubjectMinor
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  Data: <i>Keywords: </i>Blood glucose regulation; In vitro fermentation; Intestinal flora; Metabolomics; Porphyra haitanensis polyphenols
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  Data: 0 (Polyphenols)<br />0 (Blood Glucose)<br />0 (Plant Extracts)<br />0 (Hypoglycemic Agents)<br />0 (Sodium-Glucose Transporter 1)<br />0 (Glucose Transporter Type 2)
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  Data: 10.1016/j.foodchem.2026.150323
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        Text: English
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      – SubjectFull: Bacteria metabolism
        Type: general
      – SubjectFull: Bacteria classification
        Type: general
      – SubjectFull: Bacteria genetics
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