Academic Journal
Atypical auditory cortical processing in ADHD during early and middle childhood.
| Τίτλος: | Atypical auditory cortical processing in ADHD during early and middle childhood. |
|---|---|
| Συγγραφείς: | Pranjić M; Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, United States; Pediatrics, Harvard Medical School, Boston, MA, United States. Electronic address: marija.pranjic@childrens.harvard.edu., Likitlersuang J; Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, United States; Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States., Arnett AB; Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, United States; Pediatrics, Harvard Medical School, Boston, MA, United States. |
| Πηγή: | Developmental cognitive neuroscience [Dev Cogn Neurosci] 2026 Aug; Vol. 80, pp. 101780. Date of Electronic Publication: 2026 Jul 08. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101541838 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-9307 (Electronic) Linking ISSN: 18789293 NLM ISO Abbreviation: Dev Cogn Neurosci Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier |
| Ιατρικοί όροι (MeSH): | Attention Deficit Disorder with Hyperactivity*/physiopathology , Auditory Perception*/physiology , Evoked Potentials, Auditory*/physiology , Auditory Cortex*/physiopathology, Electroencephalography/methods ; Acoustic Stimulation/methods ; Attention/physiology ; Humans ; Child ; Female ; Male |
| Περίληψη: | Auditory perception emerges from the dynamic integration of bottom-up sensory encoding with higher-order predictive processes, and disruption of these processes is associated with poor attention and behavior regulation in children. Using an auditory oddball paradigm, we examined event-related potentials reflecting auditory deviance detection (mismatch negativity; MMN) and novelty-related orienting (novelty-P3) in early (n = 115) and middle (n = 71) childhood. Across both age-stratified cohorts, elevated attention-deficit/hyperactivity disorder (ADHD) symptoms or diagnosis were associated with altered MMN responses, whereas evidence for novelty-P3 differences was more limited. In early childhood, elevated ADHD symptoms were associated with larger negative-going MMN amplitudes and altered habituation to repeated standard and novel stimuli. In middle childhood, ADHD was associated with attenuated MMN amplitudes, while novelty-P3 group differences were sensitive to model specification. These results suggest that auditory deviance detection and novelty adaptation may be developmentally informative markers for understanding atypical attention regulation in ADHD-related phenotypes. Together, the findings support a systems-level account in which the integration of ascending sensory input with descending predictive signals supports adaptive responses to changing environments. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| References: | Clin Neurophysiol. 2019 Dec;130(12):2238-2254. (PMID: 31711004) Cereb Cortex. 2007 Jul;17(7):1694-700. (PMID: 16990437) J Assoc Res Otolaryngol. 2021 Jun;22(3):237-259. (PMID: 33909161) J Neurophysiol. 2022 May 1;127(5):1240-1252. (PMID: 35389770) Clin Neurophysiol. 2025 Jun;174:50-58. (PMID: 40209637) Neuropsychologia. 2013 Jan;51(2):235-66. (PMID: 23022430) Pediatrics. 2019 Oct;144(4):. (PMID: 31570648) Neurosci Lett. 2016 Jan 26;612:132-137. (PMID: 26628248) J Neurophysiol. 2015 Nov;114(5):2625-36. (PMID: 26311184) Neurosci Biobehav Rev. 2020 May;112:117-134. (PMID: 31991190) Psychophysiology. 2010 Jan 1;47(1):66-122. (PMID: 19686538) Ear Hear. 2000 Jun;21(3):242-51. (PMID: 10890733) Int J Educ Psychol Assess. 2012 Apr;10(1):51-70. (PMID: 26504617) Neurosci Biobehav Rev. 2022 Dec;143:104883. (PMID: 36152842) Neuroimage. 2003 Aug;19(4):1395-404. (PMID: 12948697) Clin Neurophysiol. 2013 Apr;124(4):644-57. (PMID: 23063669) Neuroreport. 2020 Jul 10;31(10):776-779. (PMID: 32453022) Dev Cogn Neurosci. 2021 Dec;52:101036. (PMID: 34801856) Neuroscience. 2013 Sep 5;247:117-33. (PMID: 23707979) Nat Rev Neurosci. 2002 Mar;3(3):201-15. (PMID: 11994752) Brain Cogn. 2018 Jun;123:110-119. (PMID: 29550506) Front Neurosci. 2018 Feb 27;12:97. (PMID: 29535597) Front Psychol. 2016 Jan 05;6:1970. (PMID: 26779082) Biol Psychiatry. 2020 Apr 15;87(8):770-780. (PMID: 31924325) Front Hum Neurosci. 2015 Oct 20;9:530. (PMID: 26539092) J Dev Behav Pediatr. 2025 Sep-Oct 01;46(5):e481-e498. (PMID: 40910865) Clin Neurophysiol. 2009 Mar;120(3):453-63. (PMID: 19181570) Int J Psychophysiol. 2022 Jul;177:43-60. (PMID: 35196572) Clin Neurophysiol. 2024 Dec;168:161-167. (PMID: 39577377) Dev Cogn Neurosci. 2025 Apr;72:101519. (PMID: 39864185) Ear Hear. 2002 Apr;23(2):118-36. (PMID: 11951848) R Soc Open Sci. 2025 Jun 11;12(6):220497. (PMID: 40503249) Dev Med Child Neurol. 2019 Apr;61(4):399-405. (PMID: 30276811) Cognition. 2010 Apr;115(1):93-103. (PMID: 20096409) Psychol Rev. 1966 Jan;73(1):16-43. (PMID: 5324565) J Neurosci. 2015 May 20;35(20):7750-62. (PMID: 25995464) Brain Sci. 2024 Oct 25;14(11):. (PMID: 39595826) Clin Neurophysiol. 2023 May;149:1-8. (PMID: 36841009) Neurosci Lett. 2023 Feb 28;798:137100. (PMID: 36720344) Nat Rev Neurosci. 2003 Mar;4(3):193-202. (PMID: 12612632) Neuroimage. 2020 Feb 15;207:116432. (PMID: 31809886) Philos Trans R Soc Lond B Biol Sci. 2021 Oct 11;376(1835):20200327. (PMID: 34420385) Clin Neurophysiol. 2007 Oct;118(10):2128-48. (PMID: 17573239) Philos Trans R Soc Lond B Biol Sci. 2005 Apr 29;360(1456):815-36. (PMID: 15937014) Cogn Behav Neurol. 2004 Mar;17(1):1-8. (PMID: 15209220) Sci Rep. 2017 Sep 14;7(1):11550. (PMID: 28912422) Clin Psychol Rev. 2012 Nov;32(7):605-17. (PMID: 22917740) Front Psychiatry. 2020 Jun 26;11:586. (PMID: 32670112) J Neural Transm (Vienna). 2015 Mar;122(3):375-91. (PMID: 24961573) Int J Audiol. 2007 Sep;46(9):460-78. (PMID: 17828663) J Neurosci. 1997 Jul 15;17(14):5528-35. (PMID: 9204934) Psychol Med. 2022 Nov;52(15):3360-3370. (PMID: 33706818) Hum Brain Mapp. 2018 Jun;39(6):2442-2454. (PMID: 29473262) Brain Sci. 2023 Jul 21;13(7):. (PMID: 37509040) Neuroimage. 2021 Jan 1;224:117396. (PMID: 32979522) Dev Cogn Neurosci. 2020 Apr;42:100752. (PMID: 32072930) Handb Clin Neurol. 2015;129:55-72. (PMID: 25726262) J Atten Disord. 2012 Oct;16(7):553-61. (PMID: 22166470) J Neurosci Methods. 2007 Aug 15;164(1):177-90. (PMID: 17517438) Child Dev. 2021 Sep;92(5):e907-e923. (PMID: 33506491) Hum Brain Mapp. 2015 Jun;36(6):2049-60. (PMID: 25648705) Nat Rev Neurosci. 2020 May;21(5):297. (PMID: 32221470) Psychophysiology. 2005 Jan;42(1):25-32. (PMID: 15720578) Hum Brain Mapp. 2015 Jul;36(7):2544-57. (PMID: 25821110) Brain Dev. 2016 Apr;38(4):355-63. (PMID: 26515724) Nat Rev Neurosci. 2021 Nov;22(11):657-673. (PMID: 34545240) Neurotoxicol Teratol. 2000 Sep-Oct;22(5):631-51. (PMID: 11106857) Front Comput Neurosci. 2018 Jul 06;12:51. (PMID: 30034331) Psychophysiology. 2020 Jul;57(7):e13371. (PMID: 30920012) Int J Psychophysiol. 2022 Apr;174:29-42. (PMID: 35124111) Clin Neurophysiol. 2007 Dec;118(12):2544-90. (PMID: 17931964) Psychophysiology. 2011 Jan;48(1):4-22. (PMID: 20880261) Acta Neurobiol Exp (Wars). 2012;72(1):51-64. (PMID: 22508084) Dev Sci. 2011 Mar;14(2):402-16. (PMID: 22213909) Hear Res. 2012 Dec;294(1-2):82-94. (PMID: 23103362) Nat Rev Neurosci. 2004 Nov;5(11):887-92. (PMID: 15496866) Front Hum Neurosci. 2019 May 28;13:168. (PMID: 31191275) Psychophysiology. 2019 Mar;56(3):e13300. (PMID: 30456921) Front Behav Neurosci. 2016 May 23;10:70. (PMID: 27242456) Sci Rep. 2020 Dec 31;10(1):22460. (PMID: 33384437) Ann N Y Acad Sci. 2015 Mar;1337:26-31. (PMID: 25773613) J Am Acad Child Adolesc Psychiatry. 2025 Oct;64(10):1132-1147. (PMID: 40250555) Electroencephalogr Clin Neurophysiol. 1975 Apr;38(4):387-401. (PMID: 46819) |
| Grant Information: | K99 MH116064 United States MH NIMH NIH HHS; R00 MH116064 United States MH NIMH NIH HHS |
| Contributed Indexing: | Keywords: ADHD; Attention regulation; Auditory processing; EEG; ERP; Habituation; Mismatch negativity; Novelty-P3 |
| Entry Date(s): | Date Created: 20260710 Date Completed: 20260811 Latest Revision: 20260821 |
| Update Code: | 20260821 |
| PubMed Central ID: | PMC13380513 |
| DOI: | 10.1016/j.dcn.2026.101780 |
| PMID: | 42430957 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-9307 |
|---|---|
| DOI: | 10.1016/j.dcn.2026.101780 |