dsRNA-mediated interference with RcβGRPs significantly reduced the resistance of Reticulitermes chinensis Snyder (Blattodea: Termitidae) to pathogens.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	dsRNA-mediated interference with RcβGRPs significantly reduced the resistance of Reticulitermes chinensis Snyder (Blattodea: Termitidae) to pathogens.
Συγγραφείς:	Xiong Y; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.; College of Forestry and Grassland, Nanjing Forestry University, Nanjing, China., Jiang D; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.; College of Forestry and Grassland, Nanjing Forestry University, Nanjing, China., Tang F; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China.; College of Forestry and Grassland, Nanjing Forestry University, Nanjing, China.
Πηγή:	Pest management science [Pest Manag Sci] 2026 Oct; Vol. 82 (10), pp. 10459-10470. Date of Electronic Publication: 2026 Jul 07.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Published for SCI by Wiley Country of Publication: England NLM ID: 100898744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-4998 (Electronic) Linking ISSN: 1526498X NLM ISO Abbreviation: Pest Manag Sci Subsets: MEDLINE
Imprint Name(s):	Original Publication: West Sussex, UK : Published for SCI by Wiley, c2000-
Ιατρικοί όροι (MeSH):	Insect Proteins/genetics , Insect Proteins/immunology , Insect Proteins/metabolism , Isoptera/immunology , Isoptera/genetics , Isoptera/microbiology , Receptors, Pattern Recognition/genetics , RNA Interference , RNA, Double-Stranded* , Immunity, Innate*, Beauveria/physiology ; Bacillus thuringiensis/physiology ; Animals ; Innate Immunity Recognition ; Carrier Proteins
Περίληψη:	Background: Reticulitermes chinensis Snyder (Blattodea: Termitidae) is a highly destructive social insect. In comparison with traditional chemical control, pathogen-based microbial control provides benefits, including environmental friendliness, although its application is frequently constrained by the robust immune system of termites. β-1,3-glucan recognition proteins (βGRPs), a key class of pattern recognition receptors, play a central role in initiating insect immune responses. Therefore, we investigated the functions of RcβGRPs in R. chinensis against infection by three pathogenic microbes, aiming to elucidate the molecular mechanism by which RcβGRPs mediate the immune defense of this termite against pathogen invasion. Results: This study investigated the functions of RcβGRP1 and RcβGRP2 in R. chinensis regarding defense against infections caused by Bacillus thuringiensis (Bt), Serratia marcescens (SM1), and Beauveria bassiana (Bb). The results showed that pathogenic infections induced upregulation of RcβGRP1 and RcβGRP2. Following interference with these two genes, the expression of multiple immune genes downstream of the Toll pathway was variably altered. Additionally, interference with RcβGRPs resulted in a significant decrease in the frequency of mutual allogrooming behavior among termites. Furthermore, as RcβGRPs were interfered with, the resistance of R. chinensis to pathogens significantly decreased. Conclusion: These findings suggest that the functions of RcβGRPs may extend beyond immune signaling at the individual level and also serve as a crucial link between individual physiological immunity and collective behavioral immunity. This study demonstrates potential roles of RcβGRPs in regulating individual and group immunity in R. chinensis and provides a theoretical foundation for enhancing termite biocontrol efficacy by targeting immune genes. © 2026 Society of Chemical Industry. (© 2026 Society of Chemical Industry.)
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Grant Information:	20KJA220003 The Natural Science Foundation of the Jiangsu Higher Education Institutions of China; Priority Academic Program Development Fund of Jiangsu Higher Education Institutions
Contributed Indexing:	Keywords: Reticulitermes chinensis Snyder; group immunity; individual immunity; pathogen; β‐1,3‐glucan recognition protein
Substance Nomenclature:	0 (Insect Proteins) 0 (RNA, Double-Stranded) 0 (beta-1,3-glucan recognition protein, insect) 0 (Receptors, Pattern Recognition) 0 (Carrier Proteins)
Entry Date(s):	Date Created: 20260708 Date Completed: 20260911 Latest Revision: 20260913
Update Code:	20260913
PubMed Central ID:	PMC13569107
DOI:	10.1002/ps.71081
PMID:	42415550
Βάση Δεδομένων:	MEDLINE

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ISSN:	1526-4998
DOI:	10.1002/ps.71081