Academic Journal
Mechanism-Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis.
| Τίτλος: | Mechanism-Driven Nanoformulations for Cognitive Impairment Induced by Intermittent Hypoxia and Periodontitis. |
|---|---|
| Συγγραφείς: | Zhang KR; Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China., Zhu T; Laboratory of Advanced Materials, Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials and State Key Laboratory of Molecular Engineering of Polymers, College of Chemistry and Materials, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China., Liu AQ; Department of Orthodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University, School of Medicine. National Clinical Research Center For Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China., Deng JJ; Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China., Han YL; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China., Qi SC; Department of Prothodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China., Liu X; Department of Multidisciplinary Consultant Center, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China., Jiang TY; Department of Neurobiology, School of Basic Medical Science, Nanjing Medical University, Nanjing, China., Zhai MR; Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China., He YY; Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China., Li XJ; Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China., Da HT; Department of Laboratory, the First Affiliated Hospital of Anhui Medical University, Hefei, China., Xu R; College & Hospital of Stomatology, Anhui Medical University, Anhui Province Key Laboratory of Oral Diseases Research, Hefei, China., Li X; Laboratory of Advanced Materials, Department of Chemistry, Shanghai Key Lab of Molecular Catalysis and Innovative Materials and State Key Laboratory of Molecular Engineering of Polymers, College of Chemistry and Materials, Fudan University, Shanghai, China.; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China., Gao J; Stomatological Institute of Integrated Innovation, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China., Liu YH; Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China. |
| Πηγή: | Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2026 Sep; Vol. 38 (49), pp. e73920. Date of Electronic Publication: 2026 Jul 07. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9885358 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4095 (Electronic) Linking ISSN: 09359648 NLM ISO Abbreviation: Adv Mater Subsets: MEDLINE |
| Imprint Name(s): | Publication: Sept. 3, 1997- : Weinheim : Wiley-VCH Original Publication: Deerfield Beach, FL : VCH Publishers, 1989- |
| Ιατρικοί όροι (MeSH): | Hypoxia*/complications , Periodontitis*/complications , Cognitive Dysfunction*/etiology , Cognitive Dysfunction*/drug therapy , Cognitive Dysfunction*/metabolism , Cognitive Dysfunction*/complications, Mitochondria/metabolism ; Mitochondria/drug effects ; Oxidative Stress/drug effects ; Porphyromonas gingivalis/metabolism ; Porphyromonas gingivalis/chemistry ; Neurons/metabolism ; Neurons/drug effects ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Hippocampus/metabolism ; Hippocampus/drug effects ; HMGB1 Protein/metabolism ; Animals ; Mice ; Male |
| Περίληψη: | Cognitive impairment is a growing global health challenge, yet its multifactorial drivers remain incompletely understood. Intermittent hypoxia (IH) and periodontitis are identified as significant independent risk factors that frequently co-occur. This study investigates the mechanisms through which these conditions accelerate cognitive decline. Here, utilizing a comorbid mouse model, we demonstrate that outer membrane vesicles (OMVs) derived from Porphyromonas gingivalis exacerbate IH-induced mitochondrial oxidative stress and neuroinflammation, leading to neuronal damage and mitochondrial dysfunction in the hippocampus. Specifically, this process is driven by the activation of the HIF-1α/HMGB1/NLRP3 signaling axis. To target this pathology, an asymmetric RVG-Au&mSiO (© 2026 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.) |
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| Grant Information: | 2024YFC3406401 National Key R&D Program of China; 2022YFC2705200 National Key R&D Program of China; GJLCZDZK-2023-01 National Key Clinical Program on Orthodontics; 2023ZZ02009 Shanghai Top Priority Research Center Program; 22525501 National Natural Science Foundation of China; 22475049 National Natural Science Foundation of China; 22405051 National Natural Science Foundation of China; 32371053 National Natural Science Foundation of China; 82571143 National Natural Science Foundation of China; 22TQ004 Shanghai Pilot Program for Basic Research-Fudan University; 2024ZDSYS02 Science and Technology Commission of Shanghai Municipality; 25PY2600100 Science and Technology Commission of Shanghai Municipality; JYZZ248 Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; 2025AHGXZK40288 Scientific Research Project of Anhui Provincial Department of Education |
| Contributed Indexing: | Keywords: cognitive impairment; intermittent hypoxia; nanoformulations; oxidative stress; periodontitis |
| Substance Nomenclature: | 0 (Hypoxia-Inducible Factor 1, alpha Subunit) 0 (NLR Family, Pyrin Domain-Containing 3 Protein) 0 (HMGB1 Protein) |
| Entry Date(s): | Date Created: 20260708 Date Completed: 20260901 Latest Revision: 20260903 |
| Update Code: | 20260903 |
| PubMed Central ID: | PMC13532445 |
| DOI: | 10.1002/adma.73920 |
| PMID: | 42415372 |
| Βάση Δεδομένων: | MEDLINE |
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