Academic Journal
Localized pH regulation via a dynamic proton-converting raft for gastroesophageal reflux disease.
| Τίτλος: | Localized pH regulation via a dynamic proton-converting raft for gastroesophageal reflux disease. |
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| Συγγραφείς: | Li Y; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and BioSensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China., Yang Y; Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan 410081, China. Electronic address: yanxiayang@hunnu.edu.cn., Zhao W; Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China., Ren Z; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and BioSensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China., Zhang N; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and BioSensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China., Cao X; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and BioSensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China., Dong Q; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and BioSensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China., Bao M; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and BioSensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China., Lv Z; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and BioSensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China., Li Z; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and BioSensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China., Lin C; Department of Gastrointestinal Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China. Electronic address: linchangwei@csu.edu.cn., Ding D; Institute of Molecular Medicine (IMM), Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China. Electronic address: Dding@sjtu.edu.cn., Chen Z; Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and BioSensing, College of Chemistry and Chemical Engineering, College of Environmental Science and Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, China. Electronic address: zhuochen@hnu.edu.cn. |
| Πηγή: | Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2026 Sep 10; Vol. 397, pp. 115162. Date of Electronic Publication: 2026 Jul 06. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Elsevier Science Publishers, 1984- |
| Ιατρικοί όροι (MeSH): | Alginates*/chemistry , Alginates*/administration & dosage , Gastroesophageal Reflux*/drug therapy , Gastroesophageal Reflux*/metabolism , Urease*/metabolism , Urease*/genetics, Hexuronic Acids/chemistry ; Hexuronic Acids/administration & dosage ; Lactococcus lactis/genetics ; Lactococcus lactis/enzymology ; Glucuronic Acid/chemistry ; Glucuronic Acid/administration & dosage ; Carbon Dioxide/metabolism ; Animals ; Hydrogen-Ion Concentration ; Protons ; Rats, Sprague-Dawley |
| Περίληψη: | Current gastroesophageal reflux disease (GERD) therapies either systemically suppress gastric acid, risking physiological disruption, or rely on antacid rafts that offer transient, non-responsive neutralization. We address this with a chemistry-centered strategy that spatially localizes proton conversion around the self-positioning raft at the gastric interface. The dynamic H+ conversion equilibrium system (DH+-CES) integrates a CO (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare no competing interests. |
| Contributed Indexing: | Keywords: Dynamic H(+) conversion; Engineered bacteria; Enzyme catalysis; Floating alginate raft; Gels |
| Substance Nomenclature: | 0 (Alginates) 0 (Protons) EC 3.5.1.5 (Urease) 0 (Hexuronic Acids) 8A5D83Q4RW (Glucuronic Acid) 142M471B3J (Carbon Dioxide) |
| Entry Date(s): | Date Created: 20260706 Date Completed: 20260826 Latest Revision: 20260907 |
| Update Code: | 20260907 |
| DOI: | 10.1016/j.jconrel.2026.115162 |
| PMID: | 42409243 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-4995 |
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| DOI: | 10.1016/j.jconrel.2026.115162 |