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Circuit transitions from fear and anxiety to suicidal brain states.

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Τίτλος: Circuit transitions from fear and anxiety to suicidal brain states.
Συγγραφείς: K S V ABG; Department of Anatomy, Gujarat Adani Institute of Medical Sciences, Gujarat, India., Khilnani AK; Department of Otorhinolaryngology, Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat, India., Thaddanee R; Department of Pediatrics, Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat, India., Verma AK; Faculty Dept of Pharmacy, MJP Rohilkhand University, Bareilly, Uttar Pradesh, India. Electronic address: akvermamjpr889@gmail.com., Boyina R; QIS College of Pharmacy, Ongole, Andhra Pradesh, India., Kosanam S; Faculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Velappanchavadi, Chennai, India.
Πηγή: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2026 Oct; Vol. 189, pp. 106848. Date of Electronic Publication: 2026 Jul 06.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Pergamon Press Country of Publication: United States NLM ID: 7806090 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7528 (Electronic) Linking ISSN: 01497634 NLM ISO Abbreviation: Neurosci Biobehav Rev Subsets: MEDLINE
Imprint Name(s): Publication: New York Ny : Pergamon Press
Original Publication: Fayetteville, N. Y., ANKHO International Inc.
Ιατρικοί όροι (MeSH): Fear*/physiology , Anxiety*/physiopathology , Brain*/physiopathology , Default Mode Network*/physiopathology , Suicidal Ideation*, Humans
Περίληψη: Fear, anxiety, and suicidality are often conceptualized along a severity continuum; however, this view fails to capture critical mechanistic differences in how threat is processed and regulated in the brain. Here, we propose a circuit-based framework in which these states represent distinct modes of neural organization defined by their temporal dynamics, network configurations, and regulatory control. Fear is mediated by phasic, stimulus-bound processing within amygdala-centered microcircuits that enable rapid and precise responses to immediate threat. Anxiety emerges through temporal expansion of threat processing, involving recruitment of bed nucleus of the stria terminalis (BNST) circuits, interoceptive amplification via insula-anterior cingulate cortex (ACC) networks, and reduced prefrontal regulation, resulting in sustained anticipatory activation. Suicidal states reflect a further reconfiguration in which threat becomes internalized within self-referential systems. Altered interactions between default mode network (DMN) regions and salience-related systems may contribute to persistent negative self-referential processing, while dysfunction in frontostriatal circuits and reduced serotonergic regulation may contribute to impaired behavioral inhibition and increased behavioral vulnerability. Across these states, three partially overlapping processes temporal persistence, internalization of threat, and impaired action regulation are proposed to represent dynamic reconfigurations within shared neural systems rather than fixed sequential stages.
(Copyright © 2026 Elsevier Ltd. All rights reserved.)
Contributed Indexing: Keywords: Anxiety networks; Default mode network; Fear circuitry; Frontostriatal control; Salience network; Suicidality
Entry Date(s): Date Created: 20260706 Date Completed: 20260813 Latest Revision: 20260813
Update Code: 20260813
DOI: 10.1016/j.neubiorev.2026.106848
PMID: 42407412
Βάση Δεδομένων: MEDLINE
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  Data: Circuit transitions from fear and anxiety to suicidal brain states.
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  Data: <searchLink fieldCode="AU" term="%22K+S+V+ABG%22">K S V ABG</searchLink>; Department of Anatomy, Gujarat Adani Institute of Medical Sciences, Gujarat, India.<br /><searchLink fieldCode="AU" term="%22Khilnani+AK%22">Khilnani AK</searchLink>; Department of Otorhinolaryngology, Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat, India.<br /><searchLink fieldCode="AU" term="%22Thaddanee+R%22">Thaddanee R</searchLink>; Department of Pediatrics, Gujarat Adani Institute of Medical Sciences, Bhuj, Gujarat, India.<br /><searchLink fieldCode="AU" term="%22Verma+AK%22">Verma AK</searchLink>; Faculty Dept of Pharmacy, MJP Rohilkhand University, Bareilly, Uttar Pradesh, India. Electronic address: akvermamjpr889@gmail.com.<br /><searchLink fieldCode="AU" term="%22Boyina+R%22">Boyina R</searchLink>; QIS College of Pharmacy, Ongole, Andhra Pradesh, India.<br /><searchLink fieldCode="AU" term="%22Kosanam+S%22">Kosanam S</searchLink>; Faculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Velappanchavadi, Chennai, India.
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  Data: <searchLink fieldCode="JN" term="%227806090%22">Neuroscience and biobehavioral reviews</searchLink> [Neurosci Biobehav Rev] 2026 Oct; Vol. 189, pp. 106848. <i>Date of Electronic Publication: </i>2026 Jul 06.
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  Data: Fear, anxiety, and suicidality are often conceptualized along a severity continuum; however, this view fails to capture critical mechanistic differences in how threat is processed and regulated in the brain. Here, we propose a circuit-based framework in which these states represent distinct modes of neural organization defined by their temporal dynamics, network configurations, and regulatory control. Fear is mediated by phasic, stimulus-bound processing within amygdala-centered microcircuits that enable rapid and precise responses to immediate threat. Anxiety emerges through temporal expansion of threat processing, involving recruitment of bed nucleus of the stria terminalis (BNST) circuits, interoceptive amplification via insula-anterior cingulate cortex (ACC) networks, and reduced prefrontal regulation, resulting in sustained anticipatory activation. Suicidal states reflect a further reconfiguration in which threat becomes internalized within self-referential systems. Altered interactions between default mode network (DMN) regions and salience-related systems may contribute to persistent negative self-referential processing, while dysfunction in frontostriatal circuits and reduced serotonergic regulation may contribute to impaired behavioral inhibition and increased behavioral vulnerability. Across these states, three partially overlapping processes temporal persistence, internalization of threat, and impaired action regulation are proposed to represent dynamic reconfigurations within shared neural systems rather than fixed sequential stages.<br /> (Copyright © 2026 Elsevier Ltd. All rights reserved.)
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  Data: <i>Keywords: </i>Anxiety networks; Default mode network; Fear circuitry; Frontostriatal control; Salience network; Suicidality
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      – TitleFull: Circuit transitions from fear and anxiety to suicidal brain states.
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