Academic Journal
Προβολή σε EDS
Συνδεδεμένο Πλήρες Κείμενο

Effects of transcranial electric stimulation on attentional functions in healthy adults: A meta-analysis.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Effects of transcranial electric stimulation on attentional functions in healthy adults: A meta-analysis.
Συγγραφείς: Takahashi T; Communication Science Laboratories, NTT, Inc., 3-1 Morinosato-Wakamiya, Atsugi, Kanagawa 243-0198, Japan. Electronic address: toru.ntt.takahashi@ntt.com., Kimura I; Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Kettegård Allé 30 (Afsnit 714), Hvidovre 2650, Denmark; Laboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan., Vafaei S; Department of Neuroinformatics, The University of Osaka, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan., Takemi M; Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527, Japan., Kawahara JI; Department of Psychology, Hokkaido University, Kita 10, Nishi 7, Kita-ku, Sapporo, Hokkaido 060-0810, Japan., Yanagisawa T; Department of Neuroinformatics, The University of Osaka, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: tyanagisawa@nsurg.med.osaka-u.ac.jp.
Πηγή: Biological psychology [Biol Psychol] 2026 Oct; Vol. 210, pp. 109342. Date of Electronic Publication: 2026 Jul 05.
Τύπος έκδοσης: Journal Article; Meta-Analysis; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 0375566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6246 (Electronic) Linking ISSN: 03010511 NLM ISO Abbreviation: Biol Psychol Subsets: MEDLINE
Imprint Name(s): Publication: Amsterdam : Elsevier Science B.V
Original Publication: Amsterdam, North-Holland.
Ιατρικοί όροι (MeSH): Attention*/physiology , Brain*/physiology , Transcranial Direct Current Stimulation*, Humans ; Adult ; Female ; Male ; Randomized Controlled Trials as Topic
Περίληψη: Non-invasive brain stimulation techniques, such as transcranial electric stimulation (tES), are increasingly promoted as methods to enhance attention. However, their efficacy and optimal stimulation targets remain uncertain. We conducted a preregistered meta-analysis of randomized controlled trials in healthy adults (58 trials, 295 outcomes) examining the effects of tES on attentional functions (PROSPERO: CRD42023487035), complemented by a performance-electric field correlation (PEC) analysis to identify brain regions most strongly linked to tES-induced behavioral improvements. In general, tES produced a small but significant improvement in attentional functions compared to control conditions (standardized mean difference [SMD] = 0.24, 95% confidence interval [CI] = 0.12-0.36, I2 = 61%). Small but consistent benefits were observed in trials assessing attentional functions after stimulation (40 trials, SMD = 0.23, 95% CI = 0.12-0.33, I2 = 39%) and in trials applying anodal transcranial direct current stimulation (tDCS) targeting prefrontal regions (vs sham; 31 trials, SMD = 0.26, 95% CI = 0.12-0.39, I2 = 46%) with no evidence of publication bias or serious imprecision. The PEC analysis further revealed that tDCS-induced electric fields in the ventral subregion of the left dorsolateral prefrontal cortex (left vDLPFC) were most strongly associated with improvements in attentional functions following tDCS. Taken together, these findings suggest that tES may enhance attentional functions and the left vDLPFC may be a potential target for future tES studies aiming to improve attention.
(Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Attention; Meta-analysis; Non-invasive brain stimulation; Performance-electric field correlation; Transcranial direct current stimulation; Transcranial electric stimulation
Entry Date(s): Date Created: 20260705 Date Completed: 20260919 Latest Revision: 20260921
Update Code: 20260921
DOI: 10.1016/j.biopsycho.2026.109342
PMID: 42402271
Βάση Δεδομένων: MEDLINE
FullText Links:
  – Type: other
    Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=4F19AA53F6190C9A0DAB&Show=Object
Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.biopsycho.2026.109342?
    Name: ScienceDirect (all content) (s7799221)
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
Header DbId: cmedm
DbLabel: MEDLINE
An: 42402271
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effects of transcranial electric stimulation on attentional functions in healthy adults: A meta-analysis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Takahashi+T%22">Takahashi T</searchLink>; Communication Science Laboratories, NTT, Inc., 3-1 Morinosato-Wakamiya, Atsugi, Kanagawa 243-0198, Japan. Electronic address: toru.ntt.takahashi@ntt.com.<br /><searchLink fieldCode="AU" term="%22Kimura+I%22">Kimura I</searchLink>; Danish Research Centre for Magnetic Resonance, Department of Radiology and Nuclear Medicine, Copenhagen University Hospital - Amager and Hvidovre, Kettegård Allé 30 (Afsnit 714), Hvidovre 2650, Denmark; Laboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics Research, 2-2-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.<br /><searchLink fieldCode="AU" term="%22Vafaei+S%22">Vafaei S</searchLink>; Department of Neuroinformatics, The University of Osaka, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Takemi+M%22">Takemi M</searchLink>; Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527, Japan.<br /><searchLink fieldCode="AU" term="%22Kawahara+JI%22">Kawahara JI</searchLink>; Department of Psychology, Hokkaido University, Kita 10, Nishi 7, Kita-ku, Sapporo, Hokkaido 060-0810, Japan.<br /><searchLink fieldCode="AU" term="%22Yanagisawa+T%22">Yanagisawa T</searchLink>; Department of Neuroinformatics, The University of Osaka, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address: tyanagisawa@nsurg.med.osaka-u.ac.jp.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%220375566%22">Biological psychology</searchLink> [Biol Psychol] 2026 Oct; Vol. 210, pp. 109342. <i>Date of Electronic Publication: </i>2026 Jul 05.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Meta-Analysis; Review
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+B%2EV%22">Elsevier Science B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0375566 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-6246 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203010511%22">03010511 </searchLink><i>NLM ISO Abbreviation: </i>Biol Psychol <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Publication</i>: Amsterdam : Elsevier Science B.V<br /><i>Original Publication</i>: Amsterdam, North-Holland.
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Attention%22">Attention*</searchLink>/<searchLink fieldCode="MM" term="%22Attention+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Brain%22">Brain*</searchLink>/<searchLink fieldCode="MM" term="%22Brain+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Transcranial+Direct+Current+Stimulation%22">Transcranial Direct Current Stimulation*</searchLink><br /><searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Randomized+Controlled+Trials+as+Topic%22">Randomized Controlled Trials as Topic</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Non-invasive brain stimulation techniques, such as transcranial electric stimulation (tES), are increasingly promoted as methods to enhance attention. However, their efficacy and optimal stimulation targets remain uncertain. We conducted a preregistered meta-analysis of randomized controlled trials in healthy adults (58 trials, 295 outcomes) examining the effects of tES on attentional functions (PROSPERO: CRD42023487035), complemented by a performance-electric field correlation (PEC) analysis to identify brain regions most strongly linked to tES-induced behavioral improvements. In general, tES produced a small but significant improvement in attentional functions compared to control conditions (standardized mean difference [SMD] = 0.24, 95% confidence interval [CI] = 0.12-0.36, I<superscript>2</superscript> = 61%). Small but consistent benefits were observed in trials assessing attentional functions after stimulation (40 trials, SMD = 0.23, 95% CI = 0.12-0.33, I<superscript>2</superscript> = 39%) and in trials applying anodal transcranial direct current stimulation (tDCS) targeting prefrontal regions (vs sham; 31 trials, SMD = 0.26, 95% CI = 0.12-0.39, I<superscript>2</superscript> = 46%) with no evidence of publication bias or serious imprecision. The PEC analysis further revealed that tDCS-induced electric fields in the ventral subregion of the left dorsolateral prefrontal cortex (left vDLPFC) were most strongly associated with improvements in attentional functions following tDCS. Taken together, these findings suggest that tES may enhance attentional functions and the left vDLPFC may be a potential target for future tES studies aiming to improve attention.<br /> (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>Attention; Meta-analysis; Non-invasive brain stimulation; Performance-electric field correlation; Transcranial direct current stimulation; Transcranial electric stimulation
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260705 <i>Date Completed: </i>20260919 <i>Latest Revision: </i>20260921
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260921
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.biopsycho.2026.109342
– Name: AN
  Label: PMID
  Group: ID
  Data: 42402271
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42402271
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.biopsycho.2026.109342
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 109342
    Subjects:
      – SubjectFull: Humans
        Type: general
      – SubjectFull: Adult
        Type: general
      – SubjectFull: Female
        Type: general
      – SubjectFull: Male
        Type: general
      – SubjectFull: Randomized Controlled Trials as Topic
        Type: general
      – SubjectFull: Attention physiology
        Type: general
      – SubjectFull: Brain physiology
        Type: general
      – SubjectFull: Transcranial Direct Current Stimulation
        Type: general
    Titles:
      – TitleFull: Effects of transcranial electric stimulation on attentional functions in healthy adults: A meta-analysis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Takahashi T
      – PersonEntity:
          Name:
            NameFull: Kimura I
      – PersonEntity:
          Name:
            NameFull: Vafaei S
      – PersonEntity:
          Name:
            NameFull: Takemi M
      – PersonEntity:
          Name:
            NameFull: Kawahara JI
      – PersonEntity:
          Name:
            NameFull: Yanagisawa T
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: 2026 Oct
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1873-6246
          Numbering:
            – Type: volume
              Value: 210
          Titles:
            – TitleFull: Biological psychology
              Type: main
ResultId 1