Academic Journal
Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.
| Τίτλος: | Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor. |
|---|---|
| Συγγραφείς: | Habib MR; Medical Malacology Department, Theodor Bilharz Research Institute, 1 Corniche El Nile St., Warrak El-Haddar, Imbaba, Giza, 12411, Egypt., Mohamed AH; Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt., AbdElhafez AR; Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt., Helmy MS; Molecular Biology Department, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.; Proteome Research Lab, Central Laboratories Network and Centers of Excellence, National Research Center, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt., Hamed AA; Microbial Chemistry Department, National Research Center, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt., Akila AIF; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 31100107, Egypt., El-Seedi HR; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 31100107, Egypt., Khalifa SAM; Neurology and Psychiatry Department, Capio Saint Göran's Hospital, Sankt Göransplan 1, 112 19, Stockholm, Sweden., Masoud HM; Molecular Biology Department, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt. hssnmasoud@yahoo.com.; Proteome Research Lab, Central Laboratories Network and Centers of Excellence, National Research Center, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt. hssnmasoud@yahoo.com. |
| Πηγή: | Scientific reports [Sci Rep] 2026 Jul 04; Vol. 16 (1). Date of Electronic Publication: 2026 Jul 04. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Snails*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Complex Mixtures*/pharmacology , Complex Mixtures*/chemistry , Proteins*/pharmacology , Proteins*/chemistry, Antioxidants/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Staphylococcus aureus/drug effects ; Candida albicans/drug effects ; Animals ; Humans ; Cell Line, Tumor ; Fresh Water ; Egypt ; HeLa Cells |
| Περίληψη: | Freshwater snails are emerging sources of bioactive molecules with potential biomedical and therapeutic relevance. This study evaluated crude protein extracts from two Egyptian freshwater snails, Lanistes carinatus and Bellamya unicolor, for antioxidant enzymes, antimicrobial and antibiofilm activities, cytotoxicity against human cancer cell lines, and peptide composition. Both species exhibited low activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST), with slightly higher levels in L. carinatus. Despite this, the crude protein extracts inhibited the growth of Escherichia coli and Staphylococcus aureus; L. carinatus showed stronger antifungal activity against Candida albicans, while neither extract affected Aspergillus niger. Selective cytotoxicity was observed: L. carinatus was most active against MCF-7 and HeLa cells, whereas B. unicolor was highly potent against HCT-116 and moderately active against PC3 cells, with minimal effects on normal WI-38 cells. LC-MS/MS identified 26 short peptides, likely contributing to the antimicrobial and anticancer activities.These findings provide preliminary evidence of the therapeutic potential of L. carinatus and B. unicolor crude protein extracts, highlighting freshwater snails as candidate sources of bioactive molecules that merit further investigation. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: These wild freshwater snails are lower invertebrates, under prevailing regional guidelines and institutional policies, the collection and use of them for survey-based and exploratory research do not require formal approval from an animal ethics committee. |
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| Contributed Indexing: | Keywords: Bellamya unicolor; Lanistes carinatus; Antibiofilm activity; Antimicrobial activity; Antioxidant enzymes; Bioactive peptides; Cytotoxicity; Freshwater snails |
| Substance Nomenclature: | 0 (Anti-Infective Agents) 0 (Antioxidants) 0 (Antineoplastic Agents) 0 (Complex Mixtures) 0 (Proteins) |
| Entry Date(s): | Date Created: 20260703 Date Completed: 20260703 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13332020 |
| DOI: | 10.1038/s41598-026-60044-5 |
| PMID: | 42399711 |
| Βάση Δεδομένων: | MEDLINE |
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