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Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.

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Τίτλος: Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.
Συγγραφείς: Habib MR; Medical Malacology Department, Theodor Bilharz Research Institute, 1 Corniche El Nile St., Warrak El-Haddar, Imbaba, Giza, 12411, Egypt., Mohamed AH; Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt., AbdElhafez AR; Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt., Helmy MS; Molecular Biology Department, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.; Proteome Research Lab, Central Laboratories Network and Centers of Excellence, National Research Center, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt., Hamed AA; Microbial Chemistry Department, National Research Center, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt., Akila AIF; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 31100107, Egypt., El-Seedi HR; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 31100107, Egypt., Khalifa SAM; Neurology and Psychiatry Department, Capio Saint Göran's Hospital, Sankt Göransplan 1, 112 19, Stockholm, Sweden., Masoud HM; Molecular Biology Department, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt. hssnmasoud@yahoo.com.; Proteome Research Lab, Central Laboratories Network and Centers of Excellence, National Research Center, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt. hssnmasoud@yahoo.com.
Πηγή: Scientific reports [Sci Rep] 2026 Jul 04; Vol. 16 (1). Date of Electronic Publication: 2026 Jul 04.
Τύπος έκδοσης: Journal Article; Research Support, Non-U.S. Gov't
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Imprint Name(s): Original Publication: London : Nature Publishing Group, copyright 2011-
Ιατρικοί όροι (MeSH): Snails*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Complex Mixtures*/pharmacology , Complex Mixtures*/chemistry , Proteins*/pharmacology , Proteins*/chemistry, Antioxidants/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Staphylococcus aureus/drug effects ; Candida albicans/drug effects ; Animals ; Humans ; Cell Line, Tumor ; Fresh Water ; Egypt ; HeLa Cells
Περίληψη: Freshwater snails are emerging sources of bioactive molecules with potential biomedical and therapeutic relevance. This study evaluated crude protein extracts from two Egyptian freshwater snails, Lanistes carinatus and Bellamya unicolor, for antioxidant enzymes, antimicrobial and antibiofilm activities, cytotoxicity against human cancer cell lines, and peptide composition. Both species exhibited low activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST), with slightly higher levels in L. carinatus. Despite this, the crude protein extracts inhibited the growth of Escherichia coli and Staphylococcus aureus; L. carinatus showed stronger antifungal activity against Candida albicans, while neither extract affected Aspergillus niger. Selective cytotoxicity was observed: L. carinatus was most active against MCF-7 and HeLa cells, whereas B. unicolor was highly potent against HCT-116 and moderately active against PC3 cells, with minimal effects on normal WI-38 cells. LC-MS/MS identified 26 short peptides, likely contributing to the antimicrobial and anticancer activities.These findings provide preliminary evidence of the therapeutic potential of L. carinatus and B. unicolor crude protein extracts, highlighting freshwater snails as candidate sources of bioactive molecules that merit further investigation.
(© 2026. The Author(s).)
Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: These wild freshwater snails are lower invertebrates, under prevailing regional guidelines and institutional policies, the collection and use of them for survey-based and exploratory research do not require formal approval from an animal ethics committee.
References: Front Med (Lausanne). 2021 Feb 10;8:614797. (PMID: 33644096)
Antibiotics (Basel). 2021 Aug 12;10(8):. (PMID: 34439019)
PeerJ. 2022 Apr 12;10:e13217. (PMID: 35433131)
Nature. 1970 Aug 15;227(5259):680-5. (PMID: 5432063)
Microorganisms. 2020 Oct 21;8(10):. (PMID: 33096635)
Comput Struct Biotechnol J. 2015 Dec 07;14:49-57. (PMID: 26862373)
Sci Rep. 2025 Sep 12;15(1):32451. (PMID: 40940399)
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. (PMID: 6606682)
Asian Pac J Cancer Prev. 2025 Dec 01;26(12):4537-4548. (PMID: 41459868)
Biochem Biophys Rep. 2015 Oct 22;4:411-416. (PMID: 29124232)
Pharm Biol. 2022 Dec;60(1):1899-1914. (PMID: 36200747)
Asian Pac J Cancer Prev. 2021 Nov 01;22(11):3467-3474. (PMID: 34837901)
Mar Drugs. 2021 Jul 14;19(7):. (PMID: 34356819)
Comp Biochem Physiol B Biochem Mol Biol. 2013 Mar;164(3):221-8. (PMID: 23333534)
J Biol Chem. 1969 Aug 25;244(16):4406-12. (PMID: 5806584)
Anal Biochem. 1976 May 7;72:248-54. (PMID: 942051)
Mar Drugs. 2010 Feb 02;8(2):255-68. (PMID: 20390104)
Prog Mol Subcell Biol. 2006;43:363-79. (PMID: 17153351)
Ecotoxicol Environ Saf. 2015 Jun;116:137-42. (PMID: 25800985)
Molecules. 2021 Jun 07;26(11):. (PMID: 34200462)
J Immunol Methods. 1986 May 22;89(2):271-7. (PMID: 3486233)
Nutr Cancer. 2017 Oct;69(7):1028-1035. (PMID: 29083237)
Molecules. 2022 Dec 27;28(1):. (PMID: 36615421)
J Ovarian Res. 2024 Sep 7;17(1):181. (PMID: 39244585)
J Genet Eng Biotechnol. 2023 Mar 8;21(1):28. (PMID: 36884105)
J Immunoassay Immunochem. 2021 May 4;42(3):211-235. (PMID: 33226881)
Contributed Indexing: Keywords: Bellamya unicolor; Lanistes carinatus; Antibiofilm activity; Antimicrobial activity; Antioxidant enzymes; Bioactive peptides; Cytotoxicity; Freshwater snails
Substance Nomenclature: 0 (Anti-Infective Agents)
0 (Antioxidants)
0 (Antineoplastic Agents)
0 (Complex Mixtures)
0 (Proteins)
Entry Date(s): Date Created: 20260703 Date Completed: 20260703 Latest Revision: 20260813
Update Code: 20260814
PubMed Central ID: PMC13332020
DOI: 10.1038/s41598-026-60044-5
PMID: 42399711
Βάση Δεδομένων: MEDLINE
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  – Url: https://dx.doi.org/doi:10.1038/s41598-026-60044-5
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  Data: Therapeutic potential of crude protein extracts from two Egyptian freshwater snails Lanistes carinatus and Bellamya unicolor.
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  Data: <searchLink fieldCode="AU" term="%22Habib+MR%22">Habib MR</searchLink>; Medical Malacology Department, Theodor Bilharz Research Institute, 1 Corniche El Nile St., Warrak El-Haddar, Imbaba, Giza, 12411, Egypt.<br /><searchLink fieldCode="AU" term="%22Mohamed+AH%22">Mohamed AH</searchLink>; Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt.<br /><searchLink fieldCode="AU" term="%22AbdElhafez+AR%22">AbdElhafez AR</searchLink>; Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom, Egypt.<br /><searchLink fieldCode="AU" term="%22Helmy+MS%22">Helmy MS</searchLink>; Molecular Biology Department, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.; Proteome Research Lab, Central Laboratories Network and Centers of Excellence, National Research Center, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Hamed+AA%22">Hamed AA</searchLink>; Microbial Chemistry Department, National Research Center, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Akila+AIF%22">Akila AIF</searchLink>; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 31100107, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Seedi+HR%22">El-Seedi HR</searchLink>; Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom, 31100107, Egypt.<br /><searchLink fieldCode="AU" term="%22Khalifa+SAM%22">Khalifa SAM</searchLink>; Neurology and Psychiatry Department, Capio Saint Göran's Hospital, Sankt Göransplan 1, 112 19, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Masoud+HM%22">Masoud HM</searchLink>; Molecular Biology Department, National Research Centre, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt. hssnmasoud@yahoo.com.; Proteome Research Lab, Central Laboratories Network and Centers of Excellence, National Research Center, 33 El-Buhouth St., Dokki, Giza, 12622, Egypt. hssnmasoud@yahoo.com.
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– Name: Abstract
  Label: Abstract
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  Data: Freshwater snails are emerging sources of bioactive molecules with potential biomedical and therapeutic relevance. This study evaluated crude protein extracts from two Egyptian freshwater snails, Lanistes carinatus and Bellamya unicolor, for antioxidant enzymes, antimicrobial and antibiofilm activities, cytotoxicity against human cancer cell lines, and peptide composition. Both species exhibited low activities of superoxide dismutase (SOD), catalase (CAT), and glutathione S-transferase (GST), with slightly higher levels in L. carinatus. Despite this, the crude protein extracts inhibited the growth of Escherichia coli and Staphylococcus aureus; L. carinatus showed stronger antifungal activity against Candida albicans, while neither extract affected Aspergillus niger. Selective cytotoxicity was observed: L. carinatus was most active against MCF-7 and HeLa cells, whereas B. unicolor was highly potent against HCT-116 and moderately active against PC3 cells, with minimal effects on normal WI-38 cells. LC-MS/MS identified 26 short peptides, likely contributing to the antimicrobial and anticancer activities.These findings provide preliminary evidence of the therapeutic potential of L. carinatus and B. unicolor crude protein extracts, highlighting freshwater snails as candidate sources of bioactive molecules that merit further investigation.<br /> (© 2026. The Author(s).)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: These wild freshwater snails are lower invertebrates, under prevailing regional guidelines and institutional policies, the collection and use of them for survey-based and exploratory research do not require formal approval from an animal ethics committee.
– Name: Ref
  Label: References
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  Data: Front Med (Lausanne). 2021 Feb 10;8:614797. (PMID: <searchLink fieldCode="PM" term="%2233644096%22">33644096)</searchLink><br />Antibiotics (Basel). 2021 Aug 12;10(8):. (PMID: <searchLink fieldCode="PM" term="%2234439019%22">34439019)</searchLink><br />PeerJ. 2022 Apr 12;10:e13217. (PMID: <searchLink fieldCode="PM" term="%2235433131%22">35433131)</searchLink><br />Nature. 1970 Aug 15;227(5259):680-5. (PMID: <searchLink fieldCode="PM" term="%225432063%22">5432063)</searchLink><br />Microorganisms. 2020 Oct 21;8(10):. (PMID: <searchLink fieldCode="PM" term="%2233096635%22">33096635)</searchLink><br />Comput Struct Biotechnol J. 2015 Dec 07;14:49-57. (PMID: <searchLink fieldCode="PM" term="%2226862373%22">26862373)</searchLink><br />Sci Rep. 2025 Sep 12;15(1):32451. (PMID: <searchLink fieldCode="PM" term="%2240940399%22">40940399)</searchLink><br />J Immunol Methods. 1983 Dec 16;65(1-2):55-63. (PMID: <searchLink fieldCode="PM" term="%226606682%22">6606682)</searchLink><br />Asian Pac J Cancer Prev. 2025 Dec 01;26(12):4537-4548. (PMID: <searchLink fieldCode="PM" term="%2241459868%22">41459868)</searchLink><br />Biochem Biophys Rep. 2015 Oct 22;4:411-416. (PMID: <searchLink fieldCode="PM" term="%2229124232%22">29124232)</searchLink><br />Pharm Biol. 2022 Dec;60(1):1899-1914. (PMID: <searchLink fieldCode="PM" term="%2236200747%22">36200747)</searchLink><br />Asian Pac J Cancer Prev. 2021 Nov 01;22(11):3467-3474. (PMID: <searchLink fieldCode="PM" term="%2234837901%22">34837901)</searchLink><br />Mar Drugs. 2021 Jul 14;19(7):. (PMID: <searchLink fieldCode="PM" term="%2234356819%22">34356819)</searchLink><br />Comp Biochem Physiol B Biochem Mol Biol. 2013 Mar;164(3):221-8. (PMID: <searchLink fieldCode="PM" term="%2223333534%22">23333534)</searchLink><br />J Biol Chem. 1969 Aug 25;244(16):4406-12. (PMID: <searchLink fieldCode="PM" term="%225806584%22">5806584)</searchLink><br />Anal Biochem. 1976 May 7;72:248-54. (PMID: <searchLink fieldCode="PM" term="%22942051%22">942051)</searchLink><br />Mar Drugs. 2010 Feb 02;8(2):255-68. (PMID: <searchLink fieldCode="PM" term="%2220390104%22">20390104)</searchLink><br />Prog Mol Subcell Biol. 2006;43:363-79. (PMID: <searchLink fieldCode="PM" term="%2217153351%22">17153351)</searchLink><br />Ecotoxicol Environ Saf. 2015 Jun;116:137-42. (PMID: <searchLink fieldCode="PM" term="%2225800985%22">25800985)</searchLink><br />Molecules. 2021 Jun 07;26(11):. (PMID: <searchLink fieldCode="PM" term="%2234200462%22">34200462)</searchLink><br />J Immunol Methods. 1986 May 22;89(2):271-7. (PMID: <searchLink fieldCode="PM" term="%223486233%22">3486233)</searchLink><br />Nutr Cancer. 2017 Oct;69(7):1028-1035. (PMID: <searchLink fieldCode="PM" term="%2229083237%22">29083237)</searchLink><br />Molecules. 2022 Dec 27;28(1):. (PMID: <searchLink fieldCode="PM" term="%2236615421%22">36615421)</searchLink><br />J Ovarian Res. 2024 Sep 7;17(1):181. (PMID: <searchLink fieldCode="PM" term="%2239244585%22">39244585)</searchLink><br />J Genet Eng Biotechnol. 2023 Mar 8;21(1):28. (PMID: <searchLink fieldCode="PM" term="%2236884105%22">36884105)</searchLink><br />J Immunoassay Immunochem. 2021 May 4;42(3):211-235. (PMID: <searchLink fieldCode="PM" term="%2233226881%22">33226881)</searchLink>
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