Academic Journal
Thoroughbred horses susceptible to recurrent exertional rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.
| Τίτλος: | Thoroughbred horses susceptible to recurrent exertional rhabdomyolysis have elevated skeletal muscle mitochondrial capacities. |
|---|---|
| Συγγραφείς: | Wesolowski LT; Department of Animal Science, Texas A&M University and AgriLife Research, College Station, Texas, United States., Artman JL; Department of Animal Science, Texas A&M University and AgriLife Research, College Station, Texas, United States., Semanchik PL; Department of Animal Science, Texas A&M University and AgriLife Research, College Station, Texas, United States., Carson CP; Department of Animal Science, Texas A&M University and AgriLife Research, College Station, Texas, United States., Fenger CK; Equine Integrated Medicine, PLC, Georgetown, Kentucky, United States., Pagan JD; Kentucky Equine Research, Versailles, Kentucky, United States., Valberg SJ; Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, United States., White-Springer SH; Department of Animal Science, Texas A&M University and AgriLife Research, College Station, Texas, United States.; Department of Kinesiology and Sport Management, Texas A&M University, College Station, Texas, United States. |
| Πηγή: | Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2026 Aug 01; Vol. 141 (2), pp. 348-354. Date of Electronic Publication: 2026 Jul 03. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 8502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1601 (Electronic) Linking ISSN: 01617567 NLM ISO Abbreviation: J Appl Physiol (1985) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bethesda, MD : American Physiological Society, c1985- |
| Ιατρικοί όροι (MeSH): | Rhabdomyolysis*/metabolism , Rhabdomyolysis*/physiopathology , Rhabdomyolysis*/veterinary , Muscle, Skeletal*/metabolism , Muscle, Skeletal*/physiopathology , Mitochondria, Muscle*/metabolism , Horse Diseases*/metabolism , Horse Diseases*/physiopathology , Physical Exertion*/physiology, Calcium/metabolism ; Physical Conditioning, Animal/physiology ; Animals ; Horses ; Female ; Oxidative Phosphorylation |
| Περίληψη: | Recurrent exertional rhabdomyolysis (RER) is a skeletal muscle disease that can intermittently impede careers of equine athletes. Manifesting as episodes of muscular stiffness and degeneration, RER causes lost training and competition days. RER is associated with abnormal intracellular calcium (Ca2+) regulation. Calcium released from the sarcoplasmic reticulum to initiate contraction may also be transported into mitochondria, which impacts energy production. RER-susceptible horses exhibit downregulated mitochondrial proteins but upregulated mitochondrial genes. Thus, mitochondrial function may be impacted by Ca2+ irregularities in RER horses. Fourteen race-fit female Thoroughbred horses were used to test the hypothesis that horses that had previously experienced at least 2 exertional rhabdomyolysis episodes (n = 8; means ± SD; 3.1 ± 1.1 yr) would have impaired skeletal muscle mitochondrial capacities compared with control racehorses (n = 6; 3.5 ± 1.4 yr). Gluteus medius samples were analyzed for oxidative phosphorylation (P) and electron transfer (E) capacities via high-resolution respirometry. Contrary to our hypothesis, integrative (per mg) NADH-linked P (P |
| Contributed Indexing: | Keywords: energetics; racehorses; rhabdomyolysis |
| Substance Nomenclature: | SY7Q814VUP (Calcium) |
| Entry Date(s): | Date Created: 20260703 Date Completed: 20260720 Latest Revision: 20260720 |
| Update Code: | 20260721 |
| DOI: | 10.1152/japplphysiol.00156.2026 |
| PMID: | 42397046 |
| Βάση Δεδομένων: | MEDLINE |
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