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Altered functional hierarchical and sequential organization in individuals with schizophrenia during auditory processing.

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Τίτλος: Altered functional hierarchical and sequential organization in individuals with schizophrenia during auditory processing.
Συγγραφείς: Choi Y; Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulsan, 44919, Republic of Korea. Electronic address: yseon22@unist.ac.kr., Fuentes-Claramonte P; FIDMAG Germanes Hospitalàries Research Foundation, Carrer del Dr. Antoni Pujadas, 38, Sant Boi de Llobregat, Barcelona, 08830, Spain; CIBERSAM (Centro de Investigación Biomédica En Red de Salud Mental) ISCIII, Avenida Monforte de Lemos, 3-5 (Pabellón 11, Planta 0), Madrid, 28029, Spain. Electronic address: pfuentes@fidmag.org., McKenna P; FIDMAG Germanes Hospitalàries Research Foundation, Carrer del Dr. Antoni Pujadas, 38, Sant Boi de Llobregat, Barcelona, 08830, Spain; CIBERSAM (Centro de Investigación Biomédica En Red de Salud Mental) ISCIII, Avenida Monforte de Lemos, 3-5 (Pabellón 11, Planta 0), Madrid, 28029, Spain. Electronic address: pmckenna@fidmag.org., Pomarol-Clotet E; FIDMAG Germanes Hospitalàries Research Foundation, Carrer del Dr. Antoni Pujadas, 38, Sant Boi de Llobregat, Barcelona, 08830, Spain; CIBERSAM (Centro de Investigación Biomédica En Red de Salud Mental) ISCIII, Avenida Monforte de Lemos, 3-5 (Pabellón 11, Planta 0), Madrid, 28029, Spain. Electronic address: epomarol-clotet@fidmag.org., Sihn D; Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulsan, 44919, Republic of Korea. Electronic address: duho.sihn@gmail.com., Kim SP; Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulsan, 44919, Republic of Korea. Electronic address: spkim@unist.ac.kr.
Πηγή: NeuroImage [Neuroimage] 2026 Sep; Vol. 338, pp. 122100. Date of Electronic Publication: 2026 Jul 01.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE
Imprint Name(s): Original Publication: Orlando, FL : Academic Press, c1992-
Ιατρικοί όροι (MeSH): Schizophrenia*/physiopathology , Schizophrenia*/diagnostic imaging , Auditory Perception*/physiology , Nerve Net*/physiopathology , Nerve Net*/diagnostic imaging, Brain Mapping/methods ; Humans ; Magnetic Resonance Imaging ; Female ; Male ; Adult ; Young Adult
Περίληψη: Schizophrenia (SZ) is a severe psychiatric disorder with heterogeneous symptoms. It often entails alterations in brain networks, conventionally probed by functional connectivity using resting-state data. This study investigated task-related alterations in brain organization, including the functional connectivity gradient and infra-slow sequential organization, during auditory tasks in individuals with SZ. Functional connectivity gradient analysis showed disrupted functional hierarchical organization in SZ. Sequential organization represented significant differences in phase shifts between SZ and healthy controls (HC) over the somatomotor, parietal, and supracallosal anterior cingulate cortex. Decoding analyses reliably classified SZ from HC using phase shift values. Particularly, phase shifts in the postcentral gyrus correlated with clinical courses. These findings indicate that SZ is characterized by abnormal hierarchical organization and infra-slow propagation during auditory processing.
(Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Auditory task; Functional connectivity gradient; Infra-slow activity; Schizophrenia; Traveling wave; fMRI
Entry Date(s): Date Created: 20260701 Date Completed: 20260731 Latest Revision: 20260731
Update Code: 20260731
DOI: 10.1016/j.neuroimage.2026.122100
PMID: 42386106
Βάση Δεδομένων: MEDLINE
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  Data: Altered functional hierarchical and sequential organization in individuals with schizophrenia during auditory processing.
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  Data: <searchLink fieldCode="AU" term="%22Choi+Y%22">Choi Y</searchLink>; Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulsan, 44919, Republic of Korea. Electronic address: yseon22@unist.ac.kr.<br /><searchLink fieldCode="AU" term="%22Fuentes-Claramonte+P%22">Fuentes-Claramonte P</searchLink>; FIDMAG Germanes Hospitalàries Research Foundation, Carrer del Dr. Antoni Pujadas, 38, Sant Boi de Llobregat, Barcelona, 08830, Spain; CIBERSAM (Centro de Investigación Biomédica En Red de Salud Mental) ISCIII, Avenida Monforte de Lemos, 3-5 (Pabellón 11, Planta 0), Madrid, 28029, Spain. Electronic address: pfuentes@fidmag.org.<br /><searchLink fieldCode="AU" term="%22McKenna+P%22">McKenna P</searchLink>; FIDMAG Germanes Hospitalàries Research Foundation, Carrer del Dr. Antoni Pujadas, 38, Sant Boi de Llobregat, Barcelona, 08830, Spain; CIBERSAM (Centro de Investigación Biomédica En Red de Salud Mental) ISCIII, Avenida Monforte de Lemos, 3-5 (Pabellón 11, Planta 0), Madrid, 28029, Spain. Electronic address: pmckenna@fidmag.org.<br /><searchLink fieldCode="AU" term="%22Pomarol-Clotet+E%22">Pomarol-Clotet E</searchLink>; FIDMAG Germanes Hospitalàries Research Foundation, Carrer del Dr. Antoni Pujadas, 38, Sant Boi de Llobregat, Barcelona, 08830, Spain; CIBERSAM (Centro de Investigación Biomédica En Red de Salud Mental) ISCIII, Avenida Monforte de Lemos, 3-5 (Pabellón 11, Planta 0), Madrid, 28029, Spain. Electronic address: epomarol-clotet@fidmag.org.<br /><searchLink fieldCode="AU" term="%22Sihn+D%22">Sihn D</searchLink>; Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulsan, 44919, Republic of Korea. Electronic address: duho.sihn@gmail.com.<br /><searchLink fieldCode="AU" term="%22Kim+SP%22">Kim SP</searchLink>; Ulsan National Institute of Science and Technology, 50, UNIST-gil, Eonyang-eup, Ulsan, 44919, Republic of Korea. Electronic address: spkim@unist.ac.kr.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9215515 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9572 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210538119%22">10538119 </searchLink><i>NLM ISO Abbreviation: </i>Neuroimage <i>Subsets: </i>MEDLINE
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  Data: <searchLink fieldCode="MM" term="%22Schizophrenia%22">Schizophrenia*</searchLink>/<searchLink fieldCode="MM" term="%22Schizophrenia+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Schizophrenia%22">Schizophrenia*</searchLink>/<searchLink fieldCode="MM" term="%22Schizophrenia+diagnostic+imaging%22">diagnostic imaging</searchLink> <br /><searchLink fieldCode="MM" term="%22Auditory+Perception%22">Auditory Perception*</searchLink>/<searchLink fieldCode="MM" term="%22Auditory+Perception+physiology%22">physiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Nerve+Net%22">Nerve Net*</searchLink>/<searchLink fieldCode="MM" term="%22Nerve+Net+physiopathology%22">physiopathology</searchLink> <br /><searchLink fieldCode="MM" term="%22Nerve+Net%22">Nerve Net*</searchLink>/<searchLink fieldCode="MM" term="%22Nerve+Net+diagnostic+imaging%22">diagnostic imaging</searchLink><br /><searchLink fieldCode="MH" term="%22Brain+Mapping%22">Brain Mapping</searchLink>/<searchLink fieldCode="MH" term="%22Brain+Mapping+methods%22">methods</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Magnetic+Resonance+Imaging%22">Magnetic Resonance Imaging</searchLink> ; <searchLink fieldCode="MH" term="%22Female%22">Female</searchLink> ; <searchLink fieldCode="MH" term="%22Male%22">Male</searchLink> ; <searchLink fieldCode="MH" term="%22Adult%22">Adult</searchLink> ; <searchLink fieldCode="MH" term="%22Young+Adult%22">Young Adult</searchLink>
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  Data: Schizophrenia (SZ) is a severe psychiatric disorder with heterogeneous symptoms. It often entails alterations in brain networks, conventionally probed by functional connectivity using resting-state data. This study investigated task-related alterations in brain organization, including the functional connectivity gradient and infra-slow sequential organization, during auditory tasks in individuals with SZ. Functional connectivity gradient analysis showed disrupted functional hierarchical organization in SZ. Sequential organization represented significant differences in phase shifts between SZ and healthy controls (HC) over the somatomotor, parietal, and supracallosal anterior cingulate cortex. Decoding analyses reliably classified SZ from HC using phase shift values. Particularly, phase shifts in the postcentral gyrus correlated with clinical courses. These findings indicate that SZ is characterized by abnormal hierarchical organization and infra-slow propagation during auditory processing.<br /> (Copyright © 2026 The Authors. Published by Elsevier Inc. All rights reserved.)
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  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Data: <i>Keywords: </i>Auditory task; Functional connectivity gradient; Infra-slow activity; Schizophrenia; Traveling wave; fMRI
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