Academic Journal
Oncological Safety of Minimally Invasive Multivisceral Resection for cT4b Rectal Cancer: A Multicenter Comparison With Open Surgery.
| Title: | Oncological Safety of Minimally Invasive Multivisceral Resection for cT4b Rectal Cancer: A Multicenter Comparison With Open Surgery. |
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| Authors: | Nambara S; Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan; nambara.sho.341@m.kyushu-u.ac.jp., Ando K; Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan., Harima T; Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan., Ikeda S; Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan., Kawazoe T; Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan., Hasuda H; Department of Gastroenterological Surgery and Clinical Research Institute Cancer Research Division, National Kyushu Medical Center, Fukuoka, Japan., Nonaka K; Department of Gastrointestinal Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan., Kasagi Y; Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan., Tsuda Y; Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan., Fujinaka Y; Department of Surgery, Iizuka Hospital, Iizuka, Japan., Nakanoko T; Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan., Nakanishi R; Department of Gastroenterological Surgery and Clinical Research Institute Cancer Research Division, National Kyushu Medical Center, Fukuoka, Japan., Sugiyama M; Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan., Yoshida D; Clinical Research Institute and Department of Surgery, National Beppu Medical Center, Beppu, Japan., Ohgaki K; Department of Gastrointestinal Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan., Oki E; Department of Advanced Medicine and Innovative Technology, Kyushu University Hospital, Higashiku, Japan., Yoshizumi T; Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. |
| Source: | In vivo (Athens, Greece) [In Vivo] 2026 Jul-Aug; Vol. 40 (4), pp. 2237-2246. |
| Publication Type: | Journal Article; Multicenter Study; Comparative Study |
| Language: | English |
| Journal Info: | Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8806809 Publication Model: Print Cited Medium: Internet ISSN: 1791-7549 (Electronic) Linking ISSN: 0258851X NLM ISO Abbreviation: In Vivo Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2000- > : Attiki, Greece : International Institute of Anticancer Research Original Publication: Athens : Dr. J.G. Delinassios |
| MeSH Terms: | Rectal Neoplasms*/surgery , Rectal Neoplasms*/pathology , Rectal Neoplasms*/mortality , Minimally Invasive Surgical Procedures*/methods , Minimally Invasive Surgical Procedures*/adverse effects, Laparoscopy/methods ; Robotic Surgical Procedures/methods ; Humans ; Female ; Male ; Neoplasm Staging ; Aged ; Treatment Outcome ; Middle Aged ; Retrospective Studies ; Postoperative Complications |
| Abstract: | Background/aim: Minimally invasive surgery (MIS), including laparoscopic and robotic approaches, is increasingly used for rectal cancer but evidence of multivisceral resection (MVR) for cT4b disease by MIS is limited. This study compared short- and long-term outcomes between patients who underwent MIS or open MVR for advanced rectal cancer. Patients and Methods: We retrospectively analyzed 32 patients with cT4b rectal cancer who underwent rectal resection with MVR at six institutions between 2011 and 2023 (open, n=9; MIS, n=23). Operative invasiveness, postoperative complications, and 3-year survival were evaluated. Results: Intraoperative blood loss was lower in the MIS group than in the open group (median: 220 vs. 2,500 ml; p<0.0001). After excluding those with stage IV disease (open, n=9; MIS, n=20), pathological outcomes and 3-year survival did not differ between groups. Conclusion: MIS may reduce invasiveness without compromising oncological outcomes in selected patients with cT4b rectal cancer requiring MVR. (Copyright © 2026, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.) |
| Contributed Indexing: | Keywords: cT4b rectal cancer; laparoscopic surgery; minimally invasive surgery; multivisceral resection; robotic surgery |
| Entry Date(s): | Date Created: 20260630 Date Completed: 20260701 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13322046 |
| DOI: | 10.21873/invivo.14375 |
| PMID: | 42379757 |
| Database: | MEDLINE |
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