Academic Journal
Hispidin-enriched Sanhuangporus sanghuang ethanolic extract: A novel GLP-1 inducer with non-mutagenic properties.
| Τίτλος: | Hispidin-enriched Sanhuangporus sanghuang ethanolic extract: A novel GLP-1 inducer with non-mutagenic properties. |
|---|---|
| Συγγραφείς: | Chen YY; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan., Lin TW; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan., Chu HT; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan., Li TJ; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan., Chu YL; Department of Food Science, College of Agriculture National Pingtung University of Science and Technology, Pingtung County 912, Taiwan., Li IC; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan. Electronic address: ichen.li@grapeking.com.tw., Chen CC; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan; Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan 320, Taiwan; Institute of BioPharmaceutical Science, National Sun Yat-sen University, Kaohsiung 804, Taiwan. Electronic address: gkbioeng@grapeking.com.tw. |
| Πηγή: | Fitoterapia [Fitoterapia] 2026 Sep; Vol. 193, pp. 107355. Date of Electronic Publication: 2026 Jun 30. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1999- : [Amsterdam] : Elsevier Original Publication: Milano : Inverni & Della Beffa S.p.A. |
| Ιατρικοί όροι (MeSH): | Glucagon-Like Peptide 1*/metabolism , Pyrones*/pharmacology , Pyrones*/chemistry , Pyrones*/isolation & purification , Hypoglycemic Agents*/pharmacology, Ethanol/chemistry ; Molecular Docking Simulation ; Animals ; Humans ; Mice ; Micronucleus Tests |
| Περίληψη: | While traditionally valued for its medicinal properties, studies on Sanghuangporus sanghuang have mainly focused on its α-glucosidase inhibition and polysaccharides. This pioneering study presents four significant innovations in antidiabetic research. First, we report an unprecedented breakthrough in hispidin production, achieving a concentration of 287.3 mg/g in the S. sanghuang ethanol extract (GKSSEt), which represents a substantial increase over conventional preparations. Second, hispidin-enriched GKSSEt showed no evidence of genotoxicity under the Ames test, in vitro mammalian chromosome aberration test, and in vivo mammalian erythrocyte micronucleus test, following OECD guidelines. Third, we unveil antidiabetic mechanisms through comprehensive molecular investigations, demonstrating hispidin-enriched GKSSEt's action in stimulatin GLP-1 secretion. Fourth, our molecular docking analyses reveal previously unreported binding interactions, with fasciculine A, hypholomine B, and inoscavin A showing superior affinities to GLP-1 receptor. Our research positions hispidin-enriched GKSSEt as a promising therapeutic candidate and suggests a novel strategy for diabetes management through the synergistic action of concentrated bioactive compounds. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ying-Yu Chen, Ting-Wei Lin, Hsin-Tung Chu, Tsung-Ju Li, I-Chen Li, Chin-Chu Chen reports a relationship with Grape King Bio Ltd. that includes: employment. Yung-Lin Chu reports a relationship with Department of Food Science, College of Agriculture National Pingtung University of Science and Technology that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: GLP-1 secretion; Hispidin-enriched Sanghuangporus sanghuang GKSSEt; Molecular docking; OECD |
| Substance Nomenclature: | SSJ18CG55E (hispidin) 89750-14-1 (Glucagon-Like Peptide 1) 0 (Pyrones) 0 (Hypoglycemic Agents) 3K9958V90M (Ethanol) |
| Entry Date(s): | Date Created: 20260630 Date Completed: 20260813 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| DOI: | 10.1016/j.fitote.2026.107355 |
| PMID: | 42379430 |
| Βάση Δεδομένων: | MEDLINE |
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