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Hispidin-enriched Sanhuangporus sanghuang ethanolic extract: A novel GLP-1 inducer with non-mutagenic properties.

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Τίτλος: Hispidin-enriched Sanhuangporus sanghuang ethanolic extract: A novel GLP-1 inducer with non-mutagenic properties.
Συγγραφείς: Chen YY; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan., Lin TW; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan., Chu HT; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan., Li TJ; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan., Chu YL; Department of Food Science, College of Agriculture National Pingtung University of Science and Technology, Pingtung County 912, Taiwan., Li IC; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan. Electronic address: ichen.li@grapeking.com.tw., Chen CC; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan; Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan 320, Taiwan; Institute of BioPharmaceutical Science, National Sun Yat-sen University, Kaohsiung 804, Taiwan. Electronic address: gkbioeng@grapeking.com.tw.
Πηγή: Fitoterapia [Fitoterapia] 2026 Sep; Vol. 193, pp. 107355. Date of Electronic Publication: 2026 Jun 30.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE
Imprint Name(s): Publication: 1999- : [Amsterdam] : Elsevier
Original Publication: Milano : Inverni & Della Beffa S.p.A.
Ιατρικοί όροι (MeSH): Glucagon-Like Peptide 1*/metabolism , Pyrones*/pharmacology , Pyrones*/chemistry , Pyrones*/isolation & purification , Hypoglycemic Agents*/pharmacology, Ethanol/chemistry ; Molecular Docking Simulation ; Animals ; Humans ; Mice ; Micronucleus Tests
Περίληψη: While traditionally valued for its medicinal properties, studies on Sanghuangporus sanghuang have mainly focused on its α-glucosidase inhibition and polysaccharides. This pioneering study presents four significant innovations in antidiabetic research. First, we report an unprecedented breakthrough in hispidin production, achieving a concentration of 287.3 mg/g in the S. sanghuang ethanol extract (GKSSEt), which represents a substantial increase over conventional preparations. Second, hispidin-enriched GKSSEt showed no evidence of genotoxicity under the Ames test, in vitro mammalian chromosome aberration test, and in vivo mammalian erythrocyte micronucleus test, following OECD guidelines. Third, we unveil antidiabetic mechanisms through comprehensive molecular investigations, demonstrating hispidin-enriched GKSSEt's action in stimulatin GLP-1 secretion. Fourth, our molecular docking analyses reveal previously unreported binding interactions, with fasciculine A, hypholomine B, and inoscavin A showing superior affinities to GLP-1 receptor. Our research positions hispidin-enriched GKSSEt as a promising therapeutic candidate and suggests a novel strategy for diabetes management through the synergistic action of concentrated bioactive compounds.
(Copyright © 2026 Elsevier B.V. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ying-Yu Chen, Ting-Wei Lin, Hsin-Tung Chu, Tsung-Ju Li, I-Chen Li, Chin-Chu Chen reports a relationship with Grape King Bio Ltd. that includes: employment. Yung-Lin Chu reports a relationship with Department of Food Science, College of Agriculture National Pingtung University of Science and Technology that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: GLP-1 secretion; Hispidin-enriched Sanghuangporus sanghuang GKSSEt; Molecular docking; OECD
Substance Nomenclature: SSJ18CG55E (hispidin)
89750-14-1 (Glucagon-Like Peptide 1)
0 (Pyrones)
0 (Hypoglycemic Agents)
3K9958V90M (Ethanol)
Entry Date(s): Date Created: 20260630 Date Completed: 20260813 Latest Revision: 20260813
Update Code: 20260814
DOI: 10.1016/j.fitote.2026.107355
PMID: 42379430
Βάση Δεδομένων: MEDLINE
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  – Url: https://www.doi.org/10.1016/j.fitote.2026.107355?
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Hispidin-enriched Sanhuangporus sanghuang ethanolic extract: A novel GLP-1 inducer with non-mutagenic properties.
– Name: Author
  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Chen+YY%22">Chen YY</searchLink>; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+TW%22">Lin TW</searchLink>; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chu+HT%22">Chu HT</searchLink>; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+TJ%22">Li TJ</searchLink>; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chu+YL%22">Chu YL</searchLink>; Department of Food Science, College of Agriculture National Pingtung University of Science and Technology, Pingtung County 912, Taiwan.<br /><searchLink fieldCode="AU" term="%22Li+IC%22">Li IC</searchLink>; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan. Electronic address: ichen.li@grapeking.com.tw.<br /><searchLink fieldCode="AU" term="%22Chen+CC%22">Chen CC</searchLink>; Biotech Research Institute, Grape King Bio Ltd., Taoyuan 325, Taiwan; Institute of Food Science and Technology, National Taiwan University, Taipei 106, Taiwan; Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan 320, Taiwan; Institute of BioPharmaceutical Science, National Sun Yat-sen University, Kaohsiung 804, Taiwan. Electronic address: gkbioeng@grapeking.com.tw.
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  Data: <searchLink fieldCode="JN" term="%2216930290R%22">Fitoterapia</searchLink> [Fitoterapia] 2026 Sep; Vol. 193, pp. 107355. <i>Date of Electronic Publication: </i>2026 Jun 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>16930290R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-6971 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220367326X%22">0367326X </searchLink><i>NLM ISO Abbreviation: </i>Fitoterapia <i>Subsets: </i>MEDLINE
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  Data: <i>Publication</i>: 1999- : [Amsterdam] : Elsevier<br /><i>Original Publication</i>: Milano : Inverni & Della Beffa S.p.A.
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  Data: <searchLink fieldCode="MM" term="%22Glucagon-Like+Peptide+1%22">Glucagon-Like Peptide 1*</searchLink>/<searchLink fieldCode="MM" term="%22Glucagon-Like+Peptide+1+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Pyrones%22">Pyrones*</searchLink>/<searchLink fieldCode="MM" term="%22Pyrones+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Pyrones%22">Pyrones*</searchLink>/<searchLink fieldCode="MM" term="%22Pyrones+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Pyrones%22">Pyrones*</searchLink>/<searchLink fieldCode="MM" term="%22Pyrones+isolation+%26+purification%22">isolation & purification</searchLink> <br /><searchLink fieldCode="MM" term="%22Hypoglycemic+Agents%22">Hypoglycemic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Hypoglycemic+Agents+pharmacology%22">pharmacology</searchLink><br /><searchLink fieldCode="MH" term="%22Ethanol%22">Ethanol</searchLink>/<searchLink fieldCode="MH" term="%22Ethanol+chemistry%22">chemistry</searchLink> ; <searchLink fieldCode="MH" term="%22Molecular+Docking+Simulation%22">Molecular Docking Simulation</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink> ; <searchLink fieldCode="MH" term="%22Micronucleus+Tests%22">Micronucleus Tests</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: While traditionally valued for its medicinal properties, studies on Sanghuangporus sanghuang have mainly focused on its α-glucosidase inhibition and polysaccharides. This pioneering study presents four significant innovations in antidiabetic research. First, we report an unprecedented breakthrough in hispidin production, achieving a concentration of 287.3 mg/g in the S. sanghuang ethanol extract (GKSSEt), which represents a substantial increase over conventional preparations. Second, hispidin-enriched GKSSEt showed no evidence of genotoxicity under the Ames test, in vitro mammalian chromosome aberration test, and in vivo mammalian erythrocyte micronucleus test, following OECD guidelines. Third, we unveil antidiabetic mechanisms through comprehensive molecular investigations, demonstrating hispidin-enriched GKSSEt's action in stimulatin GLP-1 secretion. Fourth, our molecular docking analyses reveal previously unreported binding interactions, with fasciculine A, hypholomine B, and inoscavin A showing superior affinities to GLP-1 receptor. Our research positions hispidin-enriched GKSSEt as a promising therapeutic candidate and suggests a novel strategy for diabetes management through the synergistic action of concentrated bioactive compounds.<br /> (Copyright © 2026 Elsevier B.V. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ying-Yu Chen, Ting-Wei Lin, Hsin-Tung Chu, Tsung-Ju Li, I-Chen Li, Chin-Chu Chen reports a relationship with Grape King Bio Ltd. that includes: employment. Yung-Lin Chu reports a relationship with Department of Food Science, College of Agriculture National Pingtung University of Science and Technology that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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  Data: <i>Keywords: </i>GLP-1 secretion; Hispidin-enriched Sanghuangporus sanghuang GKSSEt; Molecular docking; OECD
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  Data: SSJ18CG55E (hispidin)<br />89750-14-1 (Glucagon-Like Peptide 1)<br />0 (Pyrones)<br />0 (Hypoglycemic Agents)<br />3K9958V90M (Ethanol)
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