Knowledge of cancer genetics and attitudes about genetic counseling and testing: a randomized trial of the Know Your Risk intervention compared to conventional genetic counseling.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Knowledge of cancer genetics and attitudes about genetic counseling and testing: a randomized trial of the Know Your Risk intervention compared to conventional genetic counseling.
Συγγραφείς:	Katz ML; Division of Health Behavior and Health Promotion, College of Public Health, The Ohio State University, Columbus, OH, USA. mira.katz@osumc.edu.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. mira.katz@osumc.edu.; The Ohio State University, Room 212, 3650 Olentangy River Road, Columbus, OH, 43214, USA. mira.katz@osumc.edu., Schnell PM; Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH, USA., Reiter PL; Division of Health Behavior and Health Promotion, College of Public Health, The Ohio State University, Columbus, OH, USA.; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA., Senter L; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.; Division of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA., Aeilts A; Division of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA., Spears C; Division of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA., Cooper J; Division of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA., Brown J; Division of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA., Shane-Carson KP; Division of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA., Agnese DM; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.; Division of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.; Department of Surgery, College of Medicine, The Ohio State University, Columbus, OH, USA., Toland AE; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.; Division of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.; Department of Cancer Biology and Genetics, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA., Sweet K; Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.; Division of Human Genetics, Department of Internal Medicine, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
Πηγή:	Cancer causes & control : CCC [Cancer Causes Control] 2026 Jun 30; Vol. 37 (7). Date of Electronic Publication: 2026 Jun 30.
Τύπος έκδοσης:	Journal Article; Randomized Controlled Trial
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9100846 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7225 (Electronic) Linking ISSN: 09575243 NLM ISO Abbreviation: Cancer Causes Control Subsets: MEDLINE
Imprint Name(s):	Publication: Dordrecht : Kluwer Academic Publishers Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., 1990-
Ιατρικοί όροι (MeSH):	Genetic Counseling/methods , Genetic Counseling/psychology , Genetic Testing/methods , Breast Neoplasms/genetics , Breast Neoplasms/psychology , Breast Neoplasms/diagnosis , Health Knowledge, Attitudes, Practice*, Humans ; Female ; Middle Aged ; Adult ; Genetic Predisposition to Disease ; Surveys and Questionnaires
Περίληψη:	Purpose: To determine if the developed Know Your Risk (KYR) intervention is similar to conventional genetic counseling; we evaluated participants' knowledge of cancer genetics, breast cancer risk perception, attitudes about genetic counseling and testing, and satisfaction with genetic counseling. Methods: Women (n = 866) who screened at elevated risk for breast cancer were randomized to the KYR intervention or conventional genetic counseling (2022-2024). The KYR intervention included a series of online pre-test educational videos, direct access to genetic testing, and patient preference for receiving post-test genetic counseling. Participants completed surveys at baseline and after genetic counseling and testing. Non-inferiority hypothesis testing compared the two participant groups. Results: The mean knowledge score (range 0-12) increased in both study groups from a baseline mean of 6.87 (standard deviation (SD) = 2.46) to 8.66 (SD = 2.16) for the KYR intervention and 8.56 (SD = 2.14) for conventional counseling. Additionally, statistical analyses suggest the non-inferiority of the KYR intervention for participants' accuracy of their breast cancer risk, attitudes about genetic counseling and genetic testing, and satisfaction with genetic counseling compared to participants randomized to conventional genetic counseling. Conclusion: Findings support that the components included in the KYR intervention are non-inferior for cancer genetic knowledge, risk perception, genetic counseling and testing attitudes, and genetic counseling satisfaction among women who screen at elevated risk for breast cancer. By using the combination of components included in the KYR intervention, genetic counseling and genetic testing are more accessible, convenient, and patient-driven. Trial Registration: ClinicalTrials.gov Identifier: NCT05325151. (© 2026. The Author(s).)
Competing Interests:	Declarations. Competing interests: The authors declare no competing interests. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. The Institutional Review Board at The Ohio State University approved this study. Consent to participate: Informed consent was obtained from all individual participants included in the study.
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Contributed Indexing:	Keywords: Breast cancer; Female; Genetic counseling; Genetic testing
Molecular Sequence:	ClinicalTrials.gov NCT05325151
Entry Date(s):	Date Created: 20260630 Date Completed: 20260630 Latest Revision: 20260726
Update Code:	20260726
PubMed Central ID:	PMC13319172
DOI:	10.1007/s10552-026-02207-3
PMID:	42377622
Βάση Δεδομένων:	MEDLINE

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