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The functional relevance of human leukocyte antigens in the development of cord blood derived advanced cellular therapies: A new direction of public cord blood banks.

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Τίτλος: The functional relevance of human leukocyte antigens in the development of cord blood derived advanced cellular therapies: A new direction of public cord blood banks.
Συγγραφείς: Mallis P; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece. Electronic address: pmallis@bioacademy.gr., Chatzistamatiou T; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece., Siorenta A; Department of Immunology and National Tissue Typing Center, G. Gennimatas General Hospital of Athens, Athens, Attika, Greece., Dinou A; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece., Michalopoulos E; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece., Sarri EF; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece., Roumellioti K; Department of Immunology and National Tissue Typing Center, G. Gennimatas General Hospital of Athens, Athens, Attika, Greece., Vlachou MS; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece., Giokas CS; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece.
Πηγή: Human immunology [Hum Immunol] 2026 Aug; Vol. 87 (8), pp. 111791. Date of Electronic Publication: 2026 Jun 27.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier/North-Holland Country of Publication: United States NLM ID: 8010936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1166 (Electronic) Linking ISSN: 01988859 NLM ISO Abbreviation: Hum Immunol Subsets: MEDLINE
Imprint Name(s): Original Publication: [New York] Elsevier/North-Holland.
Ιατρικοί όροι (MeSH): HLA Antigens*/genetics , Blood Banks* , Fetal Blood* , Cord Blood Stem Cell Transplantation*, Humans ; Haplotypes ; Gene Frequency ; Alleles ; Greece ; Histocompatibility Testing ; Female ; Hematopoietic Stem Cell Transplantation ; Male
Περίληψη: CBUs have been applied as alternative source of HSCs transplantation. The increasing preference for haploidentical HSC transplantation has resulted in a reduced application of CBUs worldwide. Banked CBUs in public CBBs have been processed with the highest quality standards, representing a valuable biologic source for potential production of ATMPs. The aim of this study was to characterize the HLA allele and haplotype composition of the HCBB inventory and compare its immunogenetic profile with Greek and selected international populations. Stored CBUs (n = 461) were HLA typed and analyzed in terms of allele and haplotype distribution. Unsupervised machine learning algorithms were utilized to compare the HLA allele and haplotype frequencies with the populations registered in the DKMS. Finally, Greek hematological patients (n = 432) were HLA typed, to descriptively assess similarities in HLA allele and haplotype distributions between the HCBB inventory and a representative Greek patient cohort. The results demonstrated similar HLA allele and haplotype frequency distributions between the HCBB inventory, Greek hematological patients, and several geographically related populations. These findings provide a descriptive characterization of the HCBB inventory and indicate that its HLA profile shares common features with the populations examined.
(Copyright © 2026 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: ATMPs; CBUs; HLA; Off-the-shelf; Public CBB
Substance Nomenclature: 0 (HLA Antigens)
Entry Date(s): Date Created: 20260627 Date Completed: 20260721 Latest Revision: 20260721
Update Code: 20260722
DOI: 10.1016/j.humimm.2026.111791
PMID: 42364409
Βάση Δεδομένων: MEDLINE
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  Data: The functional relevance of human leukocyte antigens in the development of cord blood derived advanced cellular therapies: A new direction of public cord blood banks.
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  Data: <searchLink fieldCode="AU" term="%22Mallis+P%22">Mallis P</searchLink>; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece. Electronic address: pmallis@bioacademy.gr.<br /><searchLink fieldCode="AU" term="%22Chatzistamatiou+T%22">Chatzistamatiou T</searchLink>; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Siorenta+A%22">Siorenta A</searchLink>; Department of Immunology and National Tissue Typing Center, G. Gennimatas General Hospital of Athens, Athens, Attika, Greece.<br /><searchLink fieldCode="AU" term="%22Dinou+A%22">Dinou A</searchLink>; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Michalopoulos+E%22">Michalopoulos E</searchLink>; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Sarri+EF%22">Sarri EF</searchLink>; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Roumellioti+K%22">Roumellioti K</searchLink>; Department of Immunology and National Tissue Typing Center, G. Gennimatas General Hospital of Athens, Athens, Attika, Greece.<br /><searchLink fieldCode="AU" term="%22Vlachou+MS%22">Vlachou MS</searchLink>; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Giokas+CS%22">Giokas CS</searchLink>; Histocompatibility and Immunogenetics Laboratory, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Greece.
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  Data: <searchLink fieldCode="JN" term="%228010936%22">Human immunology</searchLink> [Hum Immunol] 2026 Aug; Vol. 87 (8), pp. 111791. <i>Date of Electronic Publication: </i>2026 Jun 27.
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  Data: CBUs have been applied as alternative source of HSCs transplantation. The increasing preference for haploidentical HSC transplantation has resulted in a reduced application of CBUs worldwide. Banked CBUs in public CBBs have been processed with the highest quality standards, representing a valuable biologic source for potential production of ATMPs. The aim of this study was to characterize the HLA allele and haplotype composition of the HCBB inventory and compare its immunogenetic profile with Greek and selected international populations. Stored CBUs (n = 461) were HLA typed and analyzed in terms of allele and haplotype distribution. Unsupervised machine learning algorithms were utilized to compare the HLA allele and haplotype frequencies with the populations registered in the DKMS. Finally, Greek hematological patients (n = 432) were HLA typed, to descriptively assess similarities in HLA allele and haplotype distributions between the HCBB inventory and a representative Greek patient cohort. The results demonstrated similar HLA allele and haplotype frequency distributions between the HCBB inventory, Greek hematological patients, and several geographically related populations. These findings provide a descriptive characterization of the HCBB inventory and indicate that its HLA profile shares common features with the populations examined.<br /> (Copyright © 2026 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
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  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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