Academic Journal
Προβολή σε EDS

Structural property and bioactivity evaluation of reactive oxygen species hydrogels loaded with different polyphenols.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Structural property and bioactivity evaluation of reactive oxygen species hydrogels loaded with different polyphenols.
Συγγραφείς: Fan Y; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China., Duan S; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China., Zhang H; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China., Li C; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China., Cheng G; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China., Cui T; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China. Electronic address: cuitianqi0906@163.com.
Πηγή: Food chemistry [Food Chem] 2026 Sep 15; Vol. 523, pp. 150119. Date of Electronic Publication: 2026 Jun 22.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
Imprint Name(s): Publication: Barking : Elsevier Applied Science Publishers
Original Publication: Barking, Eng., Applied Science Publishers.
Ιατρικοί όροι (MeSH): Polyphenols*/chemistry , Polyphenols*/pharmacology , Hydrogels*/chemistry , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/pharmacology , Reactive Oxygen Species*/chemistry , Reactive Oxygen Species*/pharmacology , Antioxidants*/chemistry , Antioxidants*/pharmacology , Drug Carriers*/chemistry, Staphylococcus aureus/drug effects ; Staphylococcus aureus/growth & development
Περίληψη: A multifunctional hydrogel system was constructed using gelatin, oxidized sodium alginate, and thioketal‌ via a Schiff base reaction. Three polyphenols with distinct chemical structures, 6'-O-Caffeoylarbutin (CA), gallic acid (GA), and tannic acid (TA), were loaded into the hydrogel. The physicochemical properties and bioactivities of hydrogels were systematically investigated. Results showed that the GA-loaded hydrogel exhibited a uniform honeycomb-like porous structure and displayed the optimal antioxidant activity, with an ABTS radical scavenging rate as high as 96.51%. The CA-loaded hydrogel possessed the best mechanical properties. All three hydrogels formed inhibition zones against Staphylococcus aureus and displayed favorable biocompatibility. Thioketal‌ endowed the hydrogel with the ability to release on demand in response to reactive oxygen species, and significantly enhances clearance capacity for O₂- and ·OH of hydrogels. All polyphenol-loaded hydrogels exhibited radical scavenging rates exceeding 63%. This dual-network hydrogel can serve as an ideal carrier to achieve stable loading, controlled release of active polyphenols, showing potential applications in delivery systems.
(Copyright © 2026. Published by Elsevier Ltd.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Antibacterial; Antioxidant; Multifunctional hydrogel; Polyphenols; ROS response
Substance Nomenclature: 0 (Polyphenols)
0 (Hydrogels)
0 (Anti-Bacterial Agents)
0 (Reactive Oxygen Species)
0 (Antioxidants)
0 (Drug Carriers)
Entry Date(s): Date Created: 20260626 Date Completed: 20260807 Latest Revision: 20260807
Update Code: 20260807
DOI: 10.1016/j.foodchem.2026.150119
PMID: 42361566
Βάση Δεδομένων: MEDLINE
FullText Text:
  Availability: 0
CustomLinks:
  – Url: https://www.doi.org/10.1016/j.foodchem.2026.150119?
    Name: ScienceDirect (all content) (s7799221)
    Category: fullText
    Text: View record from ScienceDirect
    MouseOverText: View record from ScienceDirect
  – Url: https://resolver.ebsco.com/c/fiv2js/result?sid=EBSCO:cmedm&genre=article&issn=18737072&ISBN=&volume=523&issue=&date=20260915&spage=150119&pages=150119&title=Food chemistry&atitle=Structural%20property%20and%20bioactivity%20evaluation%20of%20reactive%20oxygen%20species%20hydrogels%20loaded%20with%20different%20polyphenols.&aulast=Fan%20Y&id=DOI:10.1016/j.foodchem.2026.150119
    Name: Full Text Finder (for New FTF UI) (ns324271)
    Category: fullText
    Text: Full Text Finder
    MouseOverText: Full Text Finder
Header DbId: cmedm
DbLabel: MEDLINE
An: 42361566
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Structural property and bioactivity evaluation of reactive oxygen species hydrogels loaded with different polyphenols.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Fan+Y%22">Fan Y</searchLink>; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Duan+S%22">Duan S</searchLink>; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Cheng+G%22">Cheng G</searchLink>; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China.<br /><searchLink fieldCode="AU" term="%22Cui+T%22">Cui T</searchLink>; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650550, China; Yunnan International Joint Laboratory of Green Food Processing, Kunming 650500, China. Electronic address: cuitianqi0906@163.com.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%227702639%22">Food chemistry</searchLink> [Food Chem] 2026 Sep 15; Vol. 523, pp. 150119. <i>Date of Electronic Publication: </i>2026 Jun 22.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Applied+Science+Publishers%22">Elsevier Applied Science Publishers </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7702639 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-7072 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203088146%22">03088146 </searchLink><i>NLM ISO Abbreviation: </i>Food Chem <i>Subsets: </i>MEDLINE
– Name: PublisherInfo
  Label: Imprint Name(s)
  Group: PubInfo
  Data: <i>Publication</i>: Barking : Elsevier Applied Science Publishers<br /><i>Original Publication</i>: Barking, Eng., Applied Science Publishers.
– Name: SubjectMESH
  Label: MeSH Terms
  Group: Su
  Data: <searchLink fieldCode="MM" term="%22Polyphenols%22">Polyphenols*</searchLink>/<searchLink fieldCode="MM" term="%22Polyphenols+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Polyphenols%22">Polyphenols*</searchLink>/<searchLink fieldCode="MM" term="%22Polyphenols+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Hydrogels%22">Hydrogels*</searchLink>/<searchLink fieldCode="MM" term="%22Hydrogels+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Anti-Bacterial+Agents%22">Anti-Bacterial Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Anti-Bacterial+Agents+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Anti-Bacterial+Agents%22">Anti-Bacterial Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Anti-Bacterial+Agents+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Reactive+Oxygen+Species%22">Reactive Oxygen Species*</searchLink>/<searchLink fieldCode="MM" term="%22Reactive+Oxygen+Species+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Reactive+Oxygen+Species%22">Reactive Oxygen Species*</searchLink>/<searchLink fieldCode="MM" term="%22Reactive+Oxygen+Species+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Antioxidants%22">Antioxidants*</searchLink>/<searchLink fieldCode="MM" term="%22Antioxidants+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Antioxidants%22">Antioxidants*</searchLink>/<searchLink fieldCode="MM" term="%22Antioxidants+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Drug+Carriers%22">Drug Carriers*</searchLink>/<searchLink fieldCode="MM" term="%22Drug+Carriers+chemistry%22">chemistry</searchLink><br /><searchLink fieldCode="MH" term="%22Staphylococcus+aureus%22">Staphylococcus aureus</searchLink>/<searchLink fieldCode="MH" term="%22Staphylococcus+aureus+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Staphylococcus+aureus%22">Staphylococcus aureus</searchLink>/<searchLink fieldCode="MH" term="%22Staphylococcus+aureus+growth+%26+development%22">growth & development</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A multifunctional hydrogel system was constructed using gelatin, oxidized sodium alginate, and thioketal‌ via a Schiff base reaction. Three polyphenols with distinct chemical structures, 6'-O-Caffeoylarbutin (CA), gallic acid (GA), and tannic acid (TA), were loaded into the hydrogel. The physicochemical properties and bioactivities of hydrogels were systematically investigated. Results showed that the GA-loaded hydrogel exhibited a uniform honeycomb-like porous structure and displayed the optimal antioxidant activity, with an ABTS radical scavenging rate as high as 96.51%. The CA-loaded hydrogel possessed the best mechanical properties. All three hydrogels formed inhibition zones against Staphylococcus aureus and displayed favorable biocompatibility. Thioketal‌ endowed the hydrogel with the ability to release on demand in response to reactive oxygen species, and significantly enhances clearance capacity for O₂<superscript>-</superscript> and ·OH of hydrogels. All polyphenol-loaded hydrogels exhibited radical scavenging rates exceeding 63%. This dual-network hydrogel can serve as an ideal carrier to achieve stable loading, controlled release of active polyphenols, showing potential applications in delivery systems.<br /> (Copyright © 2026. Published by Elsevier Ltd.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
– Name: SubjectMinor
  Label: Contributed Indexing
  Group:
  Data: <i>Keywords: </i>Antibacterial; Antioxidant; Multifunctional hydrogel; Polyphenols; ROS response
– Name: NumberCAS
  Label: Substance Nomenclature
  Group: ID
  Data: 0 (Polyphenols)<br />0 (Hydrogels)<br />0 (Anti-Bacterial Agents)<br />0 (Reactive Oxygen Species)<br />0 (Antioxidants)<br />0 (Drug Carriers)
– Name: DateEntry
  Label: Entry Date(s)
  Group: Date
  Data: <i>Date Created: </i>20260626 <i>Date Completed: </i>20260807 <i>Latest Revision: </i>20260807
– Name: DateUpdate
  Label: Update Code
  Group: Date
  Data: 20260807
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1016/j.foodchem.2026.150119
– Name: AN
  Label: PMID
  Group: ID
  Data: 42361566
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=cmedm&AN=42361566
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.foodchem.2026.150119
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 150119
    Subjects:
      – SubjectFull: Staphylococcus aureus drug effects
        Type: general
      – SubjectFull: Staphylococcus aureus growth & development
        Type: general
      – SubjectFull: Polyphenols chemistry
        Type: general
      – SubjectFull: Polyphenols pharmacology
        Type: general
      – SubjectFull: Hydrogels chemistry
        Type: general
      – SubjectFull: Anti-Bacterial Agents chemistry
        Type: general
      – SubjectFull: Anti-Bacterial Agents pharmacology
        Type: general
      – SubjectFull: Reactive Oxygen Species chemistry
        Type: general
      – SubjectFull: Reactive Oxygen Species pharmacology
        Type: general
      – SubjectFull: Antioxidants chemistry
        Type: general
      – SubjectFull: Antioxidants pharmacology
        Type: general
      – SubjectFull: Drug Carriers chemistry
        Type: general
    Titles:
      – TitleFull: Structural property and bioactivity evaluation of reactive oxygen species hydrogels loaded with different polyphenols.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fan Y
      – PersonEntity:
          Name:
            NameFull: Duan S
      – PersonEntity:
          Name:
            NameFull: Zhang H
      – PersonEntity:
          Name:
            NameFull: Li C
      – PersonEntity:
          Name:
            NameFull: Cheng G
      – PersonEntity:
          Name:
            NameFull: Cui T
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 09
              Text: 2026 Sep 15
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1873-7072
          Numbering:
            – Type: volume
              Value: 523
          Titles:
            – TitleFull: Food chemistry
              Type: main
ResultId 1