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Unraveling corilagin's absorption and metabolism: a multimodal approach.

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Title: Unraveling corilagin's absorption and metabolism: a multimodal approach.
Authors: Wang SD; Hubei Key Laboratory of Industry Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China. yuxinc@hbut.edu.cn., Qiao CH; Hubei Key Laboratory of Industry Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China. yuxinc@hbut.edu.cn., Feng WB; Hubei Key Laboratory of Industry Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China. yuxinc@hbut.edu.cn., Liu T; Hubei Key Laboratory of Industry Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China. yuxinc@hbut.edu.cn., Wei Lu; Hubei Key Laboratory of Industry Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China. yuxinc@hbut.edu.cn., Wu DH; Hubei Key Laboratory of Industry Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China. yuxinc@hbut.edu.cn., Johnson EU; Hubei Key Laboratory of Industry Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China. yuxinc@hbut.edu.cn., Chen YX; Hubei Key Laboratory of Industry Microbiology, Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, China. yuxinc@hbut.edu.cn.
Source: Food & function [Food Funct] 2026 Jul 20; Vol. 17 (14), pp. 6488-6501. Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE
Imprint Name(s): Original Publication: Cambridge : Royal Society of Chemistry
MeSH Terms: Hydrolyzable Tannins*/metabolism , Hydrolyzable Tannins*/pharmacokinetics , Hydrolyzable Tannins*/chemistry , Glucosides*/metabolism , Glucosides*/pharmacokinetics , Intestinal Absorption*, Intestinal Mucosa/metabolism ; Animals ; Rats ; Male ; Rats, Sprague-Dawley ; Gastrointestinal Microbiome
Abstract: Corilagin is an ellagitannin, a natural product found in a wide variety of foods, but its absorption and utilization process in the mammalian intestine is still unclear. A combination of the everted intestinal sac method (in vitro), the Ussing chamber technique (ex vivo), and animal experiment (in vivo) was used to study the pharmacokinetic profile and intestinal segmental absorption and metabolism of corilagin. We have further established a new method for digesting corilagin in the presence or absence of gut microbiota by using endogenous enzymes from intestinal epithelial cells. The experimental results showed that corilagin is rapidly absorbed in rats, reaching peak concentration (Cmax = 87.64 ng mL-1) 2 h after oral administration, with a half-life of 7.94 ± 4.09 h. In the everted intestinal sac model, the jejunum exhibited the highest absorption capacity for corilagin, while in the Ussing chamber model, the duodenum was the primary absorption site. Corilagin can be metabolized into trans-2-butene-1,4-dicarboxylic acid, 1-galloyl-β-glucose, pyrogallol, and dimethyl ellagic acid. In addition, the endogenous enzyme metabolite gallic acid can be continuously utilized by gut microbiota, as observed through the new method. Moreover, 83 differential metabolites were detected by extensive targeted metabolomics analysis. These findings clarify the absorption and biotransformation pathways of corilagin in experimental models, thereby providing mechanistic insights into the intestinal metabolism of corilagin.
Substance Nomenclature: 0 (Hydrolyzable Tannins)
62LOS9TW6D (corilagin)
0 (Glucosides)
Entry Date(s): Date Created: 20260626 Date Completed: 20260720 Latest Revision: 20260722
Update Code: 20260722
DOI: 10.1039/d5fo05706j
PMID: 42359836
Database: MEDLINE
Description
ISSN:2042-650X
DOI:10.1039/d5fo05706j