Academic Journal
[Molecular mechanism of intervertebral disc cell senescence: telomeres, mitochondria, and cellular metabolic reprogramming].
| Τίτλος: | [Molecular mechanism of intervertebral disc cell senescence: telomeres, mitochondria, and cellular metabolic reprogramming]. |
|---|---|
| Συγγραφείς: | Deng W; Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; Department of Minimally Invasive Spine Surgery, The First Clinical Medical College of Guangzhou University of Chinese Medicine/The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Zhu RC; Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; Department of Minimally Invasive Spine Surgery, The First Clinical Medical College of Guangzhou University of Chinese Medicine/The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, China., Kong FG; The Second Department of Minimally Invasive Spine Surgery, Luoyang Orthopedic Hospital of Henan Province/Orthopedic Hospital of Henan Province, Zhengzhou 450000, China., Luan JY; Guangzhou University of Chinese Medicine, Guangzhou 510006, China.; The Second Department of Minimally Invasive Spine Surgery, Luoyang Orthopedic Hospital of Henan Province/Orthopedic Hospital of Henan Province, Zhengzhou 450000, China. |
| Πηγή: | Sheng li xue bao : [Acta physiologica Sinica] [Sheng Li Xue Bao] 2026 Jun 25; Vol. 78 (3), pp. 566-578. |
| Τύπος έκδοσης: | Journal Article; Review; English Abstract |
| Γλώσσα: | Chinese |
| Στοιχεία περιοδικού: | Publisher: Science Press Country of Publication: China NLM ID: 20730130R Publication Model: Print Cited Medium: Internet ISSN: 0371-0874 (Print) Linking ISSN: 03710874 NLM ISO Abbreviation: Sheng Li Xue Bao Subsets: MEDLINE |
| Imprint Name(s): | Publication: Beijing : Science Press Original Publication: Beiping, 1953- |
| Ιατρικοί όροι (MeSH): | Cellular Senescence*/physiology , Cellular Senescence*/genetics , Mitochondria*/physiology , Mitochondria*/metabolism , Telomere*/physiology , Intervertebral Disc Degeneration*/metabolism , Intervertebral Disc Degeneration*/pathology , Intervertebral Disc*/cytology , Intervertebral Disc*/metabolism , Cellular Reprogramming*, Humans ; Metabolic Reprogramming ; Animals |
| Περίληψη: | Intervertebral disc degeneration (IVDD), as a common spinal disorder, is closely associated with intervertebral disc cell senescence in its pathogenesis. Cellular senescence leads to alterations in the biomechanical properties of intervertebral discs and causes clinical symptoms including chronic pain and functional impairment. Current research demonstrates that telomere shortening, mitochondrial dysfunction, and cellular metabolic reprogramming constitute the core molecular mechanisms underlying intervertebral disc cell senescence. This review systematically examines the molecular mechanisms of intervertebral disc cell senescence, analyzes the roles of telomere dynamics, mitochondrial homeostasis imbalance, and metabolic reprogramming in this process, and summarizes corresponding potential therapeutic strategies. By elucidating these molecular mechanisms, this work provides a theoretical foundation for developing therapeutic targets to delay IVDD. |
| Entry Date(s): | Date Created: 20260626 Date Completed: 20260626 Latest Revision: 20260626 |
| Update Code: | 20260627 |
| DOI: | 10.13294/j.aps.2026.0044 |
| PMID: | 42358147 |
| Βάση Δεδομένων: | MEDLINE |
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