Academic Journal
New Monoterpenoid Indole Alkaloids as Potential Neuroprotective Agents from Uncaria hirsuta Haviland.
| Τίτλος: | New Monoterpenoid Indole Alkaloids as Potential Neuroprotective Agents from Uncaria hirsuta Haviland. |
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| Συγγραφείς: | Huang XY; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China., Cui J; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China., Wang WL; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China., Zhou HZ; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Jiang YC; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China., He X; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China., Chen HL; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China., Li LM; College of Pharmacy and Food, Southwest Minzu University, Chengdu 610041, China. |
| Πηγή: | Molecules (Basel, Switzerland) [Molecules] 2026 Jun 11; Vol. 31 (12). Date of Electronic Publication: 2026 Jun 11. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, c1995- |
| Ιατρικοί όροι (MeSH): | Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/chemistry , Neuroprotective Agents*/isolation & purification , Secologanin Tryptamine Alkaloids*/chemistry , Secologanin Tryptamine Alkaloids*/pharmacology , Secologanin Tryptamine Alkaloids*/isolation & purification , Uncaria*/chemistry , Indole Alkaloids*/chemistry , Indole Alkaloids*/pharmacology, Reactive Oxygen Species/metabolism ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Neurons/drug effects ; Neurons/metabolism ; Plant Leaves/chemistry ; Animals ; Molecular Structure ; Mice ; Cell Line ; Magnetic Resonance Spectroscopy |
| Περίληψη: | Nineteen monoterpene indole alkaloids, including twelve new ones, were successfully isolated and identified from the stems and leaves of Uncaria hirsuta (Havil.). The planar structures were elucidated by nuclear magnetic resonance (NMR), high-resolution mass (HRMS), and ultraviolet (UV) analyses. The absolute configurations of new compounds were determined using electron circular dichroism calculations in conjunction with NMR calculations. The acetylcholinesterase inhibitory activity of the isolated compounds was evaluated in vitro. In further biological evaluation, the isolated compounds were evaluated for their neuroprotective effects on HT22 neuronal cells. Six compounds demonstrated significant protective activity. Their intracellular reactive oxygen species (ROS) levels were measured using the DCFH-DA fluorescent probe, which markedly attenuated glutamate-induced ROS accumulation. The results not only enrich the knowledge on the structural diversity of monoterpene indole alkaloids but also offer substantial evidence for further pharmacological exploration. |
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| Grant Information: | U23A20516 National Natural Science Foundation of China; ZYN2024193 Southwest Minzu University |
| Contributed Indexing: | Keywords: Rubiaceae; Uncaria hirsuta Havil.; absolute configuration; monoterpene indole alkaloid; neuroprotective activity |
| Substance Nomenclature: | 0 (Neuroprotective Agents) 0 (Secologanin Tryptamine Alkaloids) 0 (Reactive Oxygen Species) 0 (Plant Extracts) 0 (Cholinesterase Inhibitors) 0 (Indole Alkaloids) |
| Entry Date(s): | Date Created: 20260626 Date Completed: 20260626 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13304808 |
| DOI: | 10.3390/molecules31122053 |
| PMID: | 42357452 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1420-3049 |
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| DOI: | 10.3390/molecules31122053 |