Academic Journal
Sustainable nanomaterial production from fruit waste: green synthesis of ZnO nanoparticles for antioxidant, antimicrobial, and therapeutic applications in wound healing and cancer therapy.
| Τίτλος: | Sustainable nanomaterial production from fruit waste: green synthesis of ZnO nanoparticles for antioxidant, antimicrobial, and therapeutic applications in wound healing and cancer therapy. |
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| Συγγραφείς: | Alqahtani AA; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia., Saeed AM; Medical Education Department, College of Medicine, Najran University, Najran, Saudi Arabia., Alam A; Subhwanti Institute of Professional Education Bettiah, Bettiah, India.; International Institute of Pharmaceutical Science and Research, Kalyani Nadia, India., Pathak K; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, India., Sahariah JJ; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh, India., Elnoubi OA; Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia., A Abdel-Wahab B; Department of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia.; Department of Pharmacology, College of Medicine, Assiut University, Assiut, Egypt., Alqahtani S; Advanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia.; Comparative Pathobiology Department, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN, USA., Alshiban NM; Advanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia., Bakir MB; Medical Education Department, College of Medicine, Najran University, Najran, Najran, Saudi Arabia., Ahmad MZ; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia. |
| Πηγή: | Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2026 Sep; Vol. 52 (9), pp. 1750-1767. Date of Electronic Publication: 2026 Jul 03. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 7802620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5762 (Electronic) Linking ISSN: 03639045 NLM ISO Abbreviation: Drug Dev Ind Pharm Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare Original Publication: New York, Dekker. |
| Ιατρικοί όροι (MeSH): | Zinc Oxide*/chemistry , Zinc Oxide*/pharmacology , Zinc Oxide*/chemical synthesis , Wound Healing*/drug effects , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Fruit*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry, Green Chemistry Technology/methods ; Plant Extracts/chemistry ; Staphylococcus aureus/drug effects ; Metal Nanoparticles/chemistry ; Pseudomonas aeruginosa/drug effects ; Anti-Bacterial Agents/pharmacology ; Nanoparticles/chemistry ; Humans ; A549 Cells ; Animals ; Microbial Sensitivity Tests |
| Περίληψη: | Objective: Green synthesis of zinc oxide (ZnO) nanoparticles (NPs) using the aqueous extract of fruit waste, investigating their antioxidants, antimicrobial, anticancer, and wound healing properties. Significance: This study presents an eco-friendly synthesis of ZnO NPs that repurpose organic fruit waste, contributing to sustainable practices in nanomaterial production. The potential applications of ZnO NPs as antioxidant, antimicrobial, and anticancer agents, as well as their role in wound healing are explored. Methods: ZnO NPs were synthesized using the aqueous extract of fruit waste, and were characterized using UV-Visible spectroscopy, dynamic light scattering (DLS), X-ray powder diffraction (XRD), Fourier transform infrared (FTIR), and SEM-EDX. Antioxidant activity was measured using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Cytotoxicity was assessed on A549 lung carcinoma cells, and antimicrobial activity was tested against Staphylococcus aureus and Pseudomonas aeruginosa. A gel formulation containing chitosan (CS) and Aloe vera (CS-AV)/ZnO NPs was evaluated for wound healing in an infected wound model. Results: The synthesized ZnO NPs exhibited nanoscale size, good colloidal stability, and polygonal morphology. They demonstrated strong antioxidant activity, dose-dependent cytotoxicity against A549 cells, and significant antibacterial effects. Incorporation of ZnO NPs into the CS-AV gel markedly enhanced wound healing, achieving complete wound closure by Day 21. Histopathological analysis further confirmed improved tissue regeneration, as evidenced by reduced inflammation, increased fibrosis, and well-developed collagen formation. Conclusion: Fruit waste-derived ZnO NPs offer promising antimicrobial, antioxidant, anticancer, and wound healing properties. |
| Contributed Indexing: | Keywords: Green chemistry; ZnO NPs; eco-friendly; fruit waste; gel; green synthesis; wound healing |
| Substance Nomenclature: | SOI2LOH54Z (Zinc Oxide) 0 (Antioxidants) 0 (Antineoplastic Agents) 0 (Plant Extracts) 0 (Anti-Bacterial Agents) 0 (Anti-Infective Agents) |
| Entry Date(s): | Date Created: 20260625 Date Completed: 20260828 Latest Revision: 20260828 |
| Update Code: | 20260828 |
| DOI: | 10.1080/03639045.2026.2695097 |
| PMID: | 42348364 |
| Βάση Δεδομένων: | MEDLINE |
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