Academic Journal
O-Glycoprotein DeGP-4 From Dioscorea esculenta (Lour.) Burkill: Isolation, Structural Characterization, and Potent Anti-Triple-Negative Breast Cancer Activity.
| Τίτλος: | O-Glycoprotein DeGP-4 From Dioscorea esculenta (Lour.) Burkill: Isolation, Structural Characterization, and Potent Anti-Triple-Negative Breast Cancer Activity. |
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| Συγγραφείς: | Xu G; College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Water Pollution Treatment & Resource Reuse of Hainan Province, Hainan Normal University, Haikou, China., Li C; College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Water Pollution Treatment & Resource Reuse of Hainan Province, Hainan Normal University, Haikou, China., Liang J; College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Water Pollution Treatment & Resource Reuse of Hainan Province, Hainan Normal University, Haikou, China., Lin JJ; College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Water Pollution Treatment & Resource Reuse of Hainan Province, Hainan Normal University, Haikou, China., Sun WY; Key Laboratory of Tropical Translational Medicine of Ministry of Education & Hainan Provincial Key Laboratory for Tropical Cardiovascular Diseases Research, Research Institute for Science and Technology Development, Hainan Medical University, Haikou, China., Yi GH; Key Laboratory of Tropical Translational Medicine of Ministry of Education & Hainan Provincial Key Laboratory for Tropical Cardiovascular Diseases Research, Research Institute for Science and Technology Development, Hainan Medical University, Haikou, China., Liu J; Department of Oncology, Ji'an Central People's Hospital, Ji'an, China., Zheng CJ; College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Water Pollution Treatment & Resource Reuse of Hainan Province, Hainan Normal University, Haikou, China., Zhang XP; College of Chemistry and Chemical Engineering, Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Water Pollution Treatment & Resource Reuse of Hainan Province, Hainan Normal University, Haikou, China. |
| Πηγή: | Chemistry & biodiversity [Chem Biodivers] 2026 Jun; Vol. 23 (6), pp. e71450. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| Ιατρικοί όροι (MeSH): | Dioscorea*/chemistry , Dioscorea*/metabolism , Glycoproteins*/chemistry , Glycoproteins*/isolation & purification , Glycoproteins*/pharmacology , Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/isolation & purification, Cell Proliferation/drug effects ; Apoptosis/drug effects ; Cell Movement/drug effects ; Humans ; Animals ; Female ; Mice ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Mice, Nude |
| Περίληψη: | The present study aimed to extract and purify the glycoprotein (DeGP-4) from Dioscorea esculenta (Lour.) Burkill, investigate its antitumor activity and molecular mechanism against MDA-MB-231 and BT-549 breast cancer cell lines. The glycoprotein DeGP-4 was isolated, which contained 48.35% carbohydrates and 50.20% proteins. DeGP-4 was identified as glycoprotein around 23.28 kDa, a purity of 93.20%, and contained 16 different amino acids, in which the Asp and Glu were predominant. The carbohydrate chain composition was predominantly mannose (53.84%), glucose (43.38%), galactose (2.08%), and arabinose (0.99%), and two O-glycosylation sites were identified at positions 94 and 146. DeGP-4 demonstrated potent inhibitory effects on the proliferation of MDA-MB-231 and BT-549 breast cancer cells, with IC (© 2026 Wiley‐VHCA AG.) |
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| Grant Information: | 22461019 National Natural Science Foundation of China; ZDYF2023SHFZ106 Natural Science Foundation of Hainan Province; YSPTZX202309 Natural Science Foundation of Hainan Province |
| Contributed Indexing: | Keywords: Dioscorea esculenta (Lour.) Burkill; antitumor activity; glycoprotein; structural composition |
| Substance Nomenclature: | 0 (Glycoproteins) 0 (Antineoplastic Agents, Phytogenic) |
| Entry Date(s): | Date Created: 20260624 Date Completed: 20260624 Latest Revision: 20260624 |
| Update Code: | 20260625 |
| DOI: | 10.1002/cbdv.71450 |
| PMID: | 42339589 |
| Βάση Δεδομένων: | MEDLINE |
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